Machine Learning Model for Predicting Recovery After Critical Illness

May 23, 2026 updated by: Karina De Oliveira Azzolin, Hospital de Clinicas de Porto Alegre

Development and Validation of a Machine Learning Model for Predicting Functional Decline and Return to Work After Critical Illness

This study aims to develop and test an artificial intelligence (AI) model to predict long-term functional status and return to work after critical illness.

The main question is:

Can we develop and validate a machine learning model to predict long-term functional status and return to work after critical illness?

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

This is a retrospective observational study using secondary data from two primary studies conducted between 2017-2019 and 2020-2022. No new participants will be recruited. Data were combined and harmonized for the present secondary analysis.

Study Type

Observational

Enrollment (Actual)

2016

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Brazil
    • Rio Grande do Sul
      • Porto Alegre, Rio Grande do Sul, Brazil, 90035-903
        • Hospital de Clínicas de Porto Alegre, Intensive Care Nursing Department

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Ten medical-surgical ICUs representing the five geopolitical regions of Brazil were selected as study sites. This study includes data from two databases with similar inclusion and exclusion criteria.

Description

Inclusion Criteria:

  • Age ≥18 years
  • ICU stay ≥ 72 hours
  • ICU stay ≥ 120 hours if the participant was admitted for elective surgery

Exclusion Criteria:

  • No telephone contact available
  • Failure to establish contact
  • Transfer to another ICU

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients in follow-up
Patients under follow-up. No interventions were performed
Other: No interventions were performed.
No interventions were performed.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Functional Status
Time Frame: 3rd, 6th and 12th months after ICU discharge
Barthel Index
3rd, 6th and 12th months after ICU discharge

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Return to Work
Time Frame: 3rd, 6th and 12th months after ICU discharge
Being employed
3rd, 6th and 12th months after ICU discharge

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospital de Clinicas de Porto Alegre

Collaborators

Federal University of Rio Grande do Sul
Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul, Brazil

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

March 15, 2026

Primary Completion (Actual)

March 20, 2026

Study Completion (Actual)

April 15, 2026

Study Registration Dates

First Submitted

May 23, 2026

First Submitted That Met QC Criteria

May 23, 2026

First Posted (Actual)

June 1, 2026

Study Record Updates

Last Update Posted (Actual)

June 1, 2026

Last Update Submitted That Met QC Criteria

May 23, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 20250554

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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