Surgery Versus Non-surgical Treatment for Esophageal Squamous Cell Carcinoma in Patients Older Than 70 Years

October 31, 2022 updated by: Yongtao Han

Sichuan Cancer Hospital & Institute

To determine whether older patients who underwent esophagectomy had better outcome survival than those who were non-surgically treated.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

2

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

68 years to 98 years (Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Data were obtained from the Sichuan Cancer Hospital & Institute Esophageal Cancer Case Management and the department of radiation oncology multicenter databases. We retrospectively analyzed esophageal squamous cell carcinoma patients who were 70 years or older, who underwent esophagectomy or radiotherapy/chemotherapy from January 2009 to December 2017. Patients were divided into two groups: surgery and non-surgery groups. We then prospectively collected data on 284 patients with esophageal squamous cell carcinoma in the Sichuan Cancer Hospital for results verification.

Description

Inclusion Criteria:

  1. Pathology confirmed ESCC,
  2. Patients with esophagectomy or radiotherapy (RT)/chemotherapy (CT),
  3. Age ≥ 70.

Exclusion Criteria:

  1. Having other malignant tumours,
  2. Missing of required data.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Observational Models: Cohort
  • Time Perspectives: Cross-Sectional

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
S group
underwent surgical treatment.
Diagnostic test: Since the data were collected retrospectively, there were no interventions
Since the data were collected retrospectively, there were no interventions
NS group
underwent non-surgical treatment with RT and/or chemoradiotherapy.
Diagnostic test: Since the data were collected retrospectively, there were no interventions
Since the data were collected retrospectively, there were no interventions

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Selection of treatment modalities for elderly patients with oesophageal cancer
Time Frame: 2009.01.01-2017.12.30
Surgical data were retrospectively collected
2009.01.01-2017.12.30

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Yongtao Han

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2009

Primary Completion (Actual)

December 30, 2019

Study Completion (Actual)

October 1, 2022

Study Registration Dates

First Submitted

October 23, 2022

First Submitted That Met QC Criteria

October 31, 2022

First Posted (Actual)

November 3, 2022

Study Record Updates

Last Update Posted (Actual)

November 3, 2022

Last Update Submitted That Met QC Criteria

October 31, 2022

Last Verified

October 1, 2022

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • SCCH-TS2022
  • No. 2020YFH0169 (Other Grant/Funding Number: the International Cooperation Projects of Science and Technology of Sichuan Province)
  • No. 320.6750.2020-15-3 (Other Grant/Funding Number: The Wu Jieping Clinical Research Projects)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

Undecided

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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