Mitochondrial Energy Metabolism in Burns (Mito Burn)

The Role of the Mitochondrian in the Metabolic Stress Response to Burn Trauma

The goal of this observational study is to assess the impact of burn injury on cellular energetics in patients that have been admitted to the burn center at Arkansas Children's Hospital for burn care and require one or more procedures to clean, debride, and repair burn wounds will be eligible to participate in this study.

During the study, we will collect the following information:

• General background information such as date of birth, height, weight, and other basic information.
• Medical information, such as: basic medical information, details of burn injury, vital signs on the day of surgery, medicines you take during your stay, and some clinical tests.
• Blood, urine, and tissue during surgeries you have during your stay.

Study Overview

• Status: Recruiting
• Conditions: Burn Injury

• Study Type: Observational
• Enrollment (Estimated): 125

Contacts and Locations

• Study Contact: Name: Craig Porter, PhD; Phone Number: 5013643340; Email: cporter@uams.edu
• Study Contact Backup: Name: Lily Cheak, B.S.; Phone Number: 5013643340; Email: lcheak@uams.edu

Study Locations

• United States
  • Arkansas
    • Little Rock, Arkansas, United States, 72202
      • Recruiting
      • Arkansas Children's Hospital
      • Principal Investigator: Craig Porter, PhD
      • Sub-Investigator: Esther Teo, MD
      • Sub-Investigator: Robert Maxson, MD
      • Sub-Investigator: Richard Yeager, MD
      • Sub-Investigator: Daniel Lozano, MD
      • Sub-Investigator: Mandy Yelvington, MS, OTR/L

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Up to 125 patients (2 years to 80 years old) will be enrolled in this study. We will recruit both males and females requiring hospital admission to the ACH burn unit for burn care.

Description

Inclusion Criteria:

• Male or Female
• Ages 2 years to 80 years
• Requiring hospital admission for burn care
• All races
• All ethnicities

Exclusion Criteria:

• Age < 2 years
• Under 10 kg in body mass
• Age > 80 years
• Active pregnancy
• Unable to provide informed consent and no legal authorized representative present
• Patient is considered moribund at the time of admission by the treating physician.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood Bioenergetics	Peripheral Blood Mononuclear Cell (PBMC) respiration	Through study completion, an average of 1 year

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Blood metabolics signatures	Peripheral Blood Mononuclear Cell (PBMC) respiration	Through study completion, an average of 1 year

Collaborators and Investigators

• Sponsor: Arkansas Children's Hospital Research Institute
• Collaborators: National Institute of General Medical Sciences (NIGMS)
• Investigators: Principal Investigator: Craig Porter, PhD, Arkansas Children's Research Institute

Study record dates

Study Major Dates

• Study Start (Actual): April 20, 2023
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): June 1, 2026

Study Registration Dates

• First Submitted: August 10, 2023
• First Submitted That Met QC Criteria: June 9, 2026
• First Posted (Actual): June 11, 2026

Study Record Updates

• Last Update Posted (Actual): June 11, 2026
• Last Update Submitted That Met QC Criteria: June 9, 2026
• Last Verified: June 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Wounds and Injuries; Burns
• Other Study ID Numbers: 263136

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No