Relationship Between Clinical Status and Nerve Conduction Test Findings in Patients With Unilateral Hemiplegia

Prevalence of Peripheral Nerve Conduction Abnormalities and Their Association With Clinical Scores in Patients With Hemiplegia

Stroke-related hemiplegia may be accompanied by peripheral nerve conduction abnormalities, which may contribute to motor impairment and functional limitations. However, the frequency of these abnormalities and their relationship with clinical status have not been fully characterized. This single-center observational study aims to evaluate the frequency of peripheral nerve conduction abnormalities identified by nerve conduction studies in patients with unilateral hemiplegia and to examine their association with motor and functional clinical assessment scores. The findings may contribute to a better understanding of peripheral nerve involvement in stroke rehabilitation.

Study Overview

• Status: Completed
• Conditions: Stroke; Hemiplegia; Intracranial Hemorrhage, Spontaneous
• Intervention / Treatment: Diagnostic test: Nerve Conduction Study

Detailed Description

This is a single-center observational study designed to evaluate peripheral nerve conduction abnormalities in patients with unilateral hemiplegia following stroke. Participants undergo standardized nerve conduction studies together with routine clinical assessments, including validated measures of motor recovery and functional status. The study aims to describe the frequency of peripheral nerve conduction abnormalities within the study population and to examine their association with clinical assessment scores. The results may improve the understanding of peripheral nerve involvement in patients with hemiplegia and provide information that may be useful for rehabilitation practice.

• Study Type: Observational
• Enrollment (Actual): 73

Contacts and Locations

Study Locations

• Turkey (Türkiye)
  • Adana, Turkey (Türkiye), 01250
    • Başkent University Adana Dr. Turgut Noyan Application and Research Center

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Adults with unilateral hemiplegia secondary to ischemic or hemorrhagic stroke who were recruited from the Department of Physical Medicine and Rehabilitation at a single tertiary care center. All participants underwent standardized nerve conduction studies and clinical assessments according to the study protocol.

Description

Inclusion Criteria:

• Adults (≥18 years of age).
• Unilateral hemiplegia secondary to ischemic or hemorrhagic stroke, or intracranial hemorrhage.
• Ability to undergo standardized nerve conduction studies and clinical assessments.
• Provision of written informed consent.

Exclusion Criteria:

• Bilateral hemiplegia.
• Hemiplegia secondary to benign or malignant intracranial tumors.
• Upper or lower extremity fracture, amputation, skin lesions preventing electrophysiological testing, or diagnosed peripheral vascular disease.
• Concomitant neurological disorders that may affect motor function or peripheral nerve conduction (e.g., Parkinson's disease, multiple sclerosis, encephalitis).
• Contraindications to nerve conduction studies (e.g., cardiac pacemaker or inability to safely undergo the examination).
• Inability to cooperate with or tolerate nerve conduction studies.

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Patients With Unilateral Post-Stroke Hemiplegia; Patients with unilateral post-stroke hemiplegia who underwent standardized nerve conduction studies and clinical assessments, including motor and functional outcome measures.	Diagnostic test: Nerve Conduction Study; Standardized motor and sensory nerve conduction studies were performed to evaluate peripheral nerve conduction abnormalities in patients with unilateral post-stroke hemiplegia. The test was used as a diagnostic assessment and was not part of a therapeutic intervention.; Other Names: NCS

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Association Between Peripheral Nerve Conduction Abnormalities and Clinical Assessment Scores	To evaluate the association between peripheral nerve conduction abnormalities identified by standardized nerve conduction studies and motor and functional outcome measures in patients with unilateral hemiplegia secondary to ischemic or hemorrhagic stroke. The frequency of peripheral nerve conduction abnormalities within the study population will also be described.	Baseline

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Fugl-Meyer Assessment (FMA) Score (Upper and Lower Extremities)	Association between peripheral nerve conduction abnormalities and motor impairment assessed using the Fugl-Meyer Assessment.	Baseline
Functional Independence Measure (FIM) Score	Association between peripheral nerve conduction abnormalities and functional independence measured using the Functional Independence Measure.	Baseline
Timed Up and Go Test (TUG)	Association between peripheral nerve conduction abnormalities and mobility performance assessed using the Timed Up and Go test.	Baseline

Collaborators and Investigators

• Sponsor: Baskent University

Study record dates

Study Major Dates

• Study Start (Actual): October 4, 2024
• Primary Completion (Actual): May 20, 2026
• Study Completion (Actual): June 24, 2026

Study Registration Dates

• First Submitted: June 29, 2026
• First Submitted That Met QC Criteria: June 29, 2026
• First Posted (Actual): July 6, 2026

Study Record Updates

• Last Update Posted (Actual): July 14, 2026
• Last Update Submitted That Met QC Criteria: July 13, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Keywords: Rehabilitation; Electrophysiology; Fugl-Meyer Assessment; nerve conduction study
• Additional Relevant MeSH Terms: Neurologic Manifestations; Cerebrovascular Disorders; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Vascular Diseases; Cardiovascular Diseases; Pathologic Processes; Hemorrhage; Paralysis; Pathological Conditions, Signs and Symptoms; Signs and Symptoms; Stroke; Intracranial Hemorrhages; Hemiplegia; Diagnostic Techniques and Procedures; Diagnosis; Diagnostic Techniques, Neurological; Electrodiagnosis; Nerve Conduction Studies
• Other Study ID Numbers: BASKENT UNIVERSITY KA24/315

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED
• IPD Plan Description: A decision regarding the sharing of individual participant data has not yet been made. Data sharing will be considered after completion of the study and publication of the primary results, in accordance with institutional policies, ethical requirements, and applicable regulations.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No