Hemorrhagic Shock in Orthopedic Fractures

Incidence and Predictors of Hemorrhagic Shock in Patients With Long Bone Fractures Presenting to the Emergency Department

The goal of this observational study is to learn about the incidence and predators of hemorrhagic shock in patients with Long bone and pelvic fractures .The main question it aims to answer is:

In which bone fracture the prediction and detection of hemorrhagic shock should be in consideration for emergency management in polytrauma patients

Study Overview

• Status: Not yet recruiting
• Conditions: Hemorrhagic Shock; Pelvic Fractures; Long Bone Fractures

Detailed Description

Trauma remains a leading cause of mortality worldwide, particularly among young adults, with hemorrhage accounting for a significant proportion of early preventable deaths . Hemorrhagic shock is a form of hypovolemic shock resulting from acute blood loss leading to inadequate tissue perfusion and oxygen delivery to meet cellular metabolic demands.

hemorrhagic shock occurs when systolic blood pressure (SBP) < 90 mmHg , Shock index ≥ 0.9 , serum lactate level ≥ 2 mmol/L or need for massive transfusion .

hemorrhagic shock is a critical complication of traumatic injuries associated with high morbidity and mortality if not promptly recognized and managed. Among traumatic injuries, fractures of long bones and the pelvis are particularly important due to their potential for substantial internal blood loss.

The Shock Index is calculated as:

Shock Index (SI) = Heart Rate (HR) ÷ Systolic Blood Pressure (SBP) Normal SI: 0.5 - 0.7 Early concern SI: ≥ 0.9 Indicative of hemorrhagic shock SI ≥ 1.0 . Long bone fractures, especially femoral fractures, can result in significant hemorrhage due to disruption of intramedullary vessels and surrounding soft tissues [4]. When multiple long bones are involved, the cumulative blood loss may be considerable and can contribute to the development of hypovolemic shock. Pelvic fractures, however, are even more concerning, as they are often associated with high-energy trauma and complex vascular injuries. The pelvis contains extensive venous plexuses and major arterial branches, making it a major source of life-threatening hemorrhage. It is estimated that venous bleeding accounts for approximately 80% of hemorrhage in pelvic fractures, primarily from the presacral and prevesical venous plexuses .

Patients with pelvic fractures frequently present with hemodynamic instability and may rapidly deteriorate into hemorrhagic shock. These injuries are associated with significant mortality, particularly when shock is present. Studies have shown that pelvic fractures complicated by hemorrhagic shock carry mortality rates of up to 30%, highlighting their severity and the need for early recognition and intervention . Furthermore, pelvic injuries are strongly associated with trauma-induced coagulopathy, which further exacerbates bleeding and worsens outcomes .

Early identification of patients at risk of hemorrhagic shock is crucial in the emergency department (ED) setting. Several clinical and laboratory parameters have been investigated as potential predictors. Variables such as shock index, lactate level, base deficit, and Glasgow Coma Scale (GCS) have been shown to correlate with severity and outcomes in trauma patients . In patients with pelvic fractures, factors such as elevated lactate, hypothermia, and unstable fracture patterns (e.g., type B and C injuries) have been identified as predictors of significant hemorrhage and the need for intervention . Additionally, parameters including shock index, mean arterial pressure, lactate, and fibrinogen levels have demonstrated strong predictive value for mortality in patients with pelvic fractures complicated by shock .

• Study Type: Observational
• Enrollment (Estimated): 250

Contacts and Locations

• Study Contact: Name: Yahia Z Elsayed, Emergency Medicine resident; Phone Number: +20 01158658683; Email: Yehia.Hafez@med.sohag.edu.eg
• Study Contact Backup: Name: Mohamed Y Mohamed, MD in orthopedic sugery; Phone Number: +20 01028900884; Email: mohamedyounis888@hotmail.com

Study Locations

• Egypt
  • Sohag, Egypt
    • Sohag University
    • Contact: sohag university; Phone Number: +20 01002552419; Email: ethics@med.sohag.edu.eg

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

patients with long bone or\and pelvic fractures presenting to the emergency department of sohag university hospital

Description

Inclusion Criteria:

• Patients aged between 18 and 65 years

• Presentation with radiologically confirmed:

  • Long bone fractures (femur, tibia, fibula, humerus, radius, ulna) and/or
  • Pelvic fractures
• Presentation within 24 hours of injury

Exclusion Criteria:

• Penetrating trauma to the abdomen and/or the chest.
• Known bleeding disorders.
• Patients on anticoagulants.
• Major external hemorrhage requiring immediate surgical control
• Isolated minor fractures (e.g., bones of hands or feet).
• Dead on arrival

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Incidence of hemorrhagic shock	Shock index ≥ .9 Systolic blood pressure measurement < 90mmHg	1 hour ,2 hours , 4 hours and 6 hours

Secondary Outcome Measures

Outcome Measure	Time Frame
Blood transfusion requirements	1st hour

Collaborators and Investigators

• Sponsor: Sohag University
• Investigators: Principal Investigator: Yahia Z Elsayed, Emergency Medicine resident, Sohag University

Study record dates

Study Major Dates

• Study Start (Estimated): July 25, 2026
• Primary Completion (Estimated): December 25, 2026
• Study Completion (Estimated): January 10, 2027

Study Registration Dates

• First Submitted: July 5, 2026
• First Submitted That Met QC Criteria: July 5, 2026
• First Posted (Actual): July 10, 2026

Study Record Updates

• Last Update Posted (Actual): July 10, 2026
• Last Update Submitted That Met QC Criteria: July 5, 2026
• Last Verified: July 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Wounds and Injuries; Pathologic Processes; Leg Injuries; Hemorrhage; Fractures, Bone; Femoral Fractures; Hip Injuries; Shock; Pathological Conditions, Signs and Symptoms; Hip Fractures; Shock, Hemorrhagic
• Other Study ID Numbers: Soh-Med-26-6-7MS

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO