Effect of Different Loading Protocols on Photofunctionalized Implants in the Posterior Maxilla (PHOTOLOAD)

July 8, 2026 updated by: Mansoura University

Effects of Different Loading Protocols on Photofunctionalized Dental Implants in the Posterior Maxilla: A Randomized Clinical Trial

This randomized clinical trial evaluates different loading protocols for UV-photofunctionalized dental implants in the posterior maxilla. Clinical and radiographic outcomes will be assessed during follow

Study Overview

Status

Active, not recruiting

Conditions

Intervention / Treatment

Detailed Description

The study compares immediate, early, and conventional loading of UV-photofunctionalized dental implants placed in the posterior maxilla. Implant stability and peri-implant tissue changes will be evaluated clinically and radiographically

Study Type

Interventional

Enrollment (Actual)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Egypt
      • Al Mansurah, Egypt
        • Faculty of Dentistry Mansoura University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • • Patients with missed single tooth or multiple teeth in posterior maxilla

    • Patients Free from any para-functional habits.
    • Patient with Adequate inter-arch relation and inter-occlusal space to accommodate the prosthetic restoration.
    • Patient with good oral hygiene.
    • Patients Willing to participate in the study's follow-up intervals.

Exclusion Criteria:

  • • Patients with any local or systemic disease that absolutely contraindicate implant placement or surgery.

    • Pregnancy.
    • Patients with any pathological lesion or aggressive periodontal disease at the planned surgical site.
    • Patients on drugs that could affect bone healing process such as bisphosphonate.
    • Smokers.
    • Uncooperative patients.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Study Group 1
It included 20 patients who received UV treated dental implants placed in maxillary posterior region which were immediately loaded within 3 days of implant placement.
Procedure: Immediate loading of UV-photofunctionalized dental implants
Immediate loading of UV-photofunctionalized dental implants placed in the posterior maxilla.
Experimental: Study Group 2
It included 20 patients who received UV-treated dental implants in the maxillary posterior region, with early loading performed 4 weeks after implant placement.
Procedure: Early loading of UV-photofunctionalized dental implants
Early loading of UV-photofunctionalized dental implants placed in the posterior maxilla.
Experimental: Study Group 3
It included 20 patients who received UV treated dental implants placed in maxillary posterior region which were conventionally loaded after 3 months
Procedure: Conventional loading of UV-photofunctionalized dental implants
Conventional loading of UV-photofunctionalized dental implants placed in the posterior maxilla

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Implant Stability
Time Frame: -Immediately after impant placement -immediately after loading -3 months after loading - 6 months after loading
Implant stability will be evaluated using Osstell device based on resonance frequency analysis (ISQ values).
-Immediately after impant placement -immediately after loading -3 months after loading - 6 months after loading
Hard Tissue (peri-implant bone)
Time Frame: - Immediately Postoperative (baseline) - 3 months after loading. - 6 months after loading.
Marginal bone loss will be assessed using CBCT measured in mm.
- Immediately Postoperative (baseline) - 3 months after loading. - 6 months after loading.

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Soft Tissue
Time Frame: At 6 months after loading.
The peri-implant mucosa will be evaluated for signs of inflammation using the Modified Sulcus Bleeding Index (mSBI).
At 6 months after loading.
Peri-implant probing depth
Time Frame: At 6 months after loading.
Probing depth will be assessed using a calibrated periodontal probe with light pressure and measured in mm.
At 6 months after loading.

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Mansoura University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 1, 2026

Primary Completion (Estimated)

July 1, 2026

Study Completion (Estimated)

August 1, 2026

Study Registration Dates

First Submitted

July 8, 2026

First Submitted That Met QC Criteria

July 8, 2026

First Posted (Actual)

July 14, 2026

Study Record Updates

Last Update Posted (Actual)

July 14, 2026

Last Update Submitted That Met QC Criteria

July 8, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • R.26.01.100

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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