Management of Polycystic Ovarian Syndrome-associated Reproductive Dysfunction Through Kefir Supplementation

July 13, 2026 updated by: Maria Aslam, University of Lahore

Managing Polycystic Ovarian Syndrome- Associated Reproductive Dysfunction Through Kefir Supplementation

Polycystic ovary syndrome (PCOS) affect around 6-12% of women of age 18-25 years. Kefir contains bioactive compounds such as lactic acid bacteria, yeast, peptides, polysaccharides and organic acids and acts as a good probiotic source.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

The target population were females between the ages of 18 and 25 years who have the history of amenorrhea or delayed periods, unusual weight gain, cyst in their ovaries, hormonal imbalance or thyroid issue. Once consent is given, participants were then be randomly assigned to receive the prescribed intervention or act as a control.

(C0) Control group: Participants were only be subjected to use a regular calorie deficit diet plan (G1) Experimental group: Participants were advised to take water 250ml of water kefir per day in their mid-morning snack time for 2 months.

At baseline, nutritional assessment based on weight and height, BMI, waist circumference, blood pressure, fasting blood glucose, lipid panels (HDL, LDL, total cholesterol, triglycerides), FHS Levels, LH levels, TSH levels was done after 8 weeks of intervention.

Study Type

Interventional

Enrollment (Actual)

50

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Pakistan
      • Lahore, Pakistan
        • The University of Lahore

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Females of age 18-25 will be selected.
  • Females suffering from amenorrhea or cycle longer then 35days were selected.
  • Females with PCOS were selected.
  • Females with BMI 18.5-29.9 were selected in this research.
  • Females with thyroid issues were selected.

Exclusion Criteria:

  • Pregnant and breast-feeding females were not included.
  • Those who smoke were not included.
  • Those who consume alcohol were not included.
  • Those suffering from endocrine diseases were not be included.
  • Those taking lipid- lowering drugs or blood pressure regulating medications were not be included.
  • Those taking antibiotics or medications related to PCOS treatment or vitamin-mineral or probiotics within 1 month prior to study inclusion.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Supportive Care
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Control Group
Calorie deficit diet plan
Other: (C0) Control group
Participants were subjected to use a regular calorie deficit diet plan
Experimental: Experimental Group
Diet plan + 250ml kefir water
Dietary supplement: (G1) Experimental group
Participants were advised to take water 250ml of water kefir per day in their mid-morning snack time for 2 months.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Lipid Profile
Time Frame: 8 weeks
Blood lipid profile were obtained using fasting blood samples to determine serum total cholesterol, high-density lipoprotein cholesterol (HD L-C), low density lipoprotein cholesterol (LDL-C) and triglycerides.
8 weeks

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
FSH (follicle stimulating hormone)
Time Frame: 8 weeks
Blood test will be done to check the reproductive health
8 weeks
LH (luteinizing hormone)
Time Frame: 8 weeks
Blood test to check the secretion of luteinizing hormone and how it triggers ovulation and stimulate testosterone production.
8 weeks

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
TSH (Thyroid stimulating hormone test)
Time Frame: 8 weeks
Blood test were done to monitor the levels of TSH.
8 weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Lahore

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 18, 2026

Primary Completion (Actual)

March 18, 2026

Study Completion (Actual)

April 18, 2026

Study Registration Dates

First Submitted

July 13, 2026

First Submitted That Met QC Criteria

July 13, 2026

First Posted (Actual)

July 17, 2026

Study Record Updates

Last Update Posted (Actual)

July 17, 2026

Last Update Submitted That Met QC Criteria

July 13, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IRB-UOL-FAHS/761/2026

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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