Evaluation of The Effect of Injectable Platelet-rich Fibrin With Collagen Membrane in Miller Class II Gingival Recession Coverage

July 15, 2026 updated by: Ahmed Ramadan Shawky Elsayed elazab, Tanta University

This study aims to evaluate the effect of injectable Platelet-Rich Fibrin (i-PRF) in combination with collagen membrane in the treatment of Miller Class II gingival recession. Gingival recession is a common periodontal condition characterized by apical displacement of the gingival margin, which may lead to aesthetic concerns, root hypersensitivity, and increased risk of root caries.

The study will include patients diagnosed with Miller Class II gingival recession. Participants will be treated using a regenerative periodontal surgical approach involving coronally advanced flap combined with injectable platelet-rich fibrin and collagen membrane. Clinical parameters such as recession depth, clinical attachment level, and keratinized tissue width will be evaluated before and after treatment at specific follow-up intervals.

The objective is to compare the effectiveness of this combined regenerative approach in improving root coverage and soft tissue healing, and to assess its potential benefits in periodontal regeneration and esthetic outcomes.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

20

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Egypt
    • Gharbia Governorate
      • Tanta, Gharbia Governorate, Egypt
        • Faculty of dentistry ,Tanta university

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion criteria:

Both males and females of age ≥ 18

Exclusion criteria:

History of systemic diseases (i.e. diabetes, autoimmune dysfunction, prolonged cortisone therapy, or chemotherapy) that contraindicated periodontal surgical treatment.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Group 1
i-PRF +collagen membrane
Procedure: Group (1)
Application of injectable platelet -rich fibrin (I-PRF) in combination with a collagen membrane during the surgical procedure to enhance soft and hard tissue healing
Other Names:
  • I-PRF+collagen membrane
Active Comparator: Group 2
CAF+SCTG
Procedure: Group 2
coronally advanced flap surgery combined with a subepithelial connective tissue graft for the treatment of gingival recession defects
Other Names:
  • CAF+ SCTG

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Keratinized Tissue Thickness
Time Frame: Baseline, 1 month ,3 months and 6 months after surgery
measured in millimeters (mm) using a endodontic file
Baseline, 1 month ,3 months and 6 months after surgery

Secondary Outcome Measures

Outcome Measure
Time Frame
Recession Depth (RD)
Time Frame: baseline,1 month,3 months,6 months after surgery
baseline,1 month,3 months,6 months after surgery
Recession Width (RW)
Time Frame: Baseline,1 month,3 months ,and 6 months after surgery
Baseline,1 month,3 months ,and 6 months after surgery
keratinized Tissue Height (KTH)
Time Frame: Baseline, 1 month, 3 months, 6 months after surgery
Baseline, 1 month, 3 months, 6 months after surgery
Probing Pocket Depth (PPD)
Time Frame: Baseline and 6 months after surgery
Baseline and 6 months after surgery

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Tanta University

Investigators

  • Principal Investigator: Shereen Abdelmoula Ali, Faculty of dentistry ,Tanta university .Tanta, Eygpt

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

July 24, 2026

Primary Completion (Estimated)

August 9, 2026

Study Completion (Estimated)

October 12, 2026

Study Registration Dates

First Submitted

July 3, 2026

First Submitted That Met QC Criteria

July 15, 2026

First Posted (Actual)

July 21, 2026

Study Record Updates

Last Update Posted (Actual)

July 21, 2026

Last Update Submitted That Met QC Criteria

July 15, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • I_PRF with collagen membrane

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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