Are white matter abnormalities associated with "unexplained dizziness"?

Hena Ahmad, Niccolò Cerchiai, Michelangelo Mancuso, Augusto P Casani, Adolfo M Bronstein, Hena Ahmad, Niccolò Cerchiai, Michelangelo Mancuso, Augusto P Casani, Adolfo M Bronstein

Abstract

Introduction: Although cerebral small vessel disease is a significant contributor to the development of imbalance and falls in the elderly, whether it causes dizziness is not known.

Methods: A retrospective case analysis was conducted for 122 dizzy patients referred to two neuro-otology tertiary centres in London and Pisa. Patients were divided into 'explained' causes of dizziness (e.g. benign positional vertigo, vestibular neuritis, orthostatic hypotension, cerebellar ataxias) and 'unexplained' dizziness. White matter hyperintensities (WMH) in MRI (T2 weighted and FLAIR sequences) were blindly rated according to the Fazekas scale.

Results: 122 patients; 58 (mean age=72, SD=7.95 years) in the 'unexplained' group and 64 (mean age=72.01, SD=8.28 years) in the 'explained' group were recruited. The overall frequency of lesions (Fazekas 1-3) significantly differed between groups (p=0.011). The frequency of severe lesions (Fazekas 3) was significantly higher in the 'unexplained' group (22%) than in the 'explained' group (5%; p=0.003).

Conclusion: Increased severity of WMH in cases of unexplained dizziness suggests that such abnormalities are likely contributory to the development of dizziness. WM lesions may induce dizziness either because patients perceive a degree of objective unsteadiness or by a disconnection syndrome involving vestibular or locomotor areas of the brain.

Keywords: Small vessel disease; Unexplained dizziness; White matter hyperintensities.

Copyright © 2015 The Authors. Published by Elsevier B.V. All rights reserved.

Figures

Fig. 1
Fig. 1
Severity of white matter disease on MRI (Fazekas scores), expressed as percentage of patients with “explained” and “unexplained” causes of dizziness.

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