Susceptibility Locus for Pregnancy-Associated Spontaneous Coronary Artery Dissection

Tamiel N Turley, Matthew L Kosel, William R Bamlet, Rajiv Gulati, Sharonne N Hayes, Marysia S Tweet, Timothy M Olson, Tamiel N Turley, Matthew L Kosel, William R Bamlet, Rajiv Gulati, Sharonne N Hayes, Marysia S Tweet, Timothy M Olson

No abstract available

Keywords: acute coronary syndrome; coronary artery dissection, spontaneous; genome-wide association studies; myocardial infarction; pregnancy.

Figures

Figure 1:. Pregnancy-associated spontaneous coronary artery dissection…
Figure 1:. Pregnancy-associated spontaneous coronary artery dissection genetic associations.
Chromosomal position and P-value −log10 scale are designated by x and y axes, respectively. (A). The horizontal red line indicates genome-wide significance (P < 5 × 10−08). (B). Eight hundred kilobase region surrounding rs28533862. Linkage disequilibrium estimates (r2) are color-coded.

References

    1. Turley TN, Theis JL, Sundsbak RS, Evans JM, O’Byrne MM, Gulati R, Tweet MS, Hayes SN, Olson TM. Rare Missense Variants in TLN1 Are Associated With Familial and Sporadic Spontaneous Coronary Artery Dissection. Circ Genomic Precis Med. 2019;12:173–182. doi:10.1161/CIRCGEN.118.002437
    1. Turley TN, O’Byrne MM, Kosel ML, de Andrade M, Gulati R, Hayes SN, Tweet MS, Olson TM. Identification of Susceptibility Loci for Spontaneous Coronary Artery Dissection. JAMA Cardiol. 2020;5:929–938. doi:10.1001/jamacardio.2020.0872
    1. Tweet MS, Hayes SN, Codsi E, Gulati R, Rose CH, Best PJM. Spontaneous Coronary Artery Dissection Associated With Pregnancy. J Am Coll Cardiol. 2017;70:426–435. doi:10.1016/j.jacc.2017.05.055
    1. Cunnick JM, Kim S, Hadsell J, Collins S, Cerra C, Reiser P, Flynn DC, Cho Y. Actin filament-associated protein 1 is required for cSrc activity and secretory activation in the lactating mammary gland. Oncogene. 2015;34:2640–2649. doi:10.1038/onc.2014.205
    1. Prakash SK, LeMaire SA, Guo DC, Russell L, Regalado ES, Golabbakhsh H, Johnson RJ, Safi HJ, Estrera AL, Coselli JS, et al.Rare copy number variants disrupt genes regulating vascular smooth muscle cell adhesion and contractility in sporadic thoracic aortic aneurysms and dissections. Am J Hum Genet. 2010;87:743–756. doi:10.1016/j.ajhg.2010.09.015.

Source: PubMed

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