Positron emission tomography (PET) imaging of prostate cancer with a gastrin releasing peptide receptor antagonist--from mice to men
Gesche Wieser, Rosalba Mansi, Anca L Grosu, Wolfgang Schultze-Seemann, Rebecca A Dumont-Walter, Philipp T Meyer, Helmut R Maecke, Jean Claude Reubi, Wolfgang A Weber, Gesche Wieser, Rosalba Mansi, Anca L Grosu, Wolfgang Schultze-Seemann, Rebecca A Dumont-Walter, Philipp T Meyer, Helmut R Maecke, Jean Claude Reubi, Wolfgang A Weber
Abstract
Ex vivo studies have shown that the gastrin releasing peptide receptor (GRPr) is overexpressed on almost all primary prostate cancers, making it a promising target for prostate cancer imaging and targeted radiotherapy.
Methods: Biodistribution, dosimetry and tumor uptake of the GRPr antagonist ⁶⁴Cu-CB-TE2A-AR06 [(⁶⁴Cu-4,11-bis(carboxymethyl)-1,4,8,11-tetraazabicyclo(6.6.2)hexadecane)-PEG₄-D-Phe-Gln-Trp-Ala-Val-Gly-His-Sta-LeuNH₂] were studied by PET/CT in four patients with newly diagnosed prostate cancer (T1c-T2b, Gleason 6-7).
Results: No adverse events were observed after injection of ⁶⁴Cu-CB-TE2A-AR06. Three of four tumors were visualized with high contrast [tumor-to-prostate ratio > 4 at 4 hours (h) post injection (p.i.)], one small tumor (T1c, < 5% tumor on biopsy specimens) showed moderate contrast (tumor-to-prostate ratio at 4 h: 1.9). Radioactivity was cleared by the kidneys and only the pancreas demonstrated significant accumulation of radioactivity, which rapidly decreased over time.
Conclusion: ⁶⁴Cu-CB-TE2A-AR06 shows very favorable characteristics for imaging prostate cancer. Future studies evaluating ⁶⁴Cu-CB-TE2A-AR06 PET/CT for prostate cancer detection, staging, active surveillance, and radiation treatment planning are necessary.
Keywords: Gastrin releasing peptide receptor; PET/CT; bombesin; prostate cancer..
Conflict of interest statement
Competing Interests: The authors have declared that no competing interest exists.
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