The Effect of Toothpastes Containing Hydroxyapatite, Fluoroapatite, and Zn-Mg-hydroxyapatite Nanocrystals on Dentin Hypersensitivity: A Randomized Clinical Trial

Maria Polyakova, Inna Sokhova, Vladlena Doroshina, Marianna Arakelyan, Nina Novozhilova, Ksenia Babina, Maria Polyakova, Inna Sokhova, Vladlena Doroshina, Marianna Arakelyan, Nina Novozhilova, Ksenia Babina

Abstract

Aims: The aim of this study was to compare the effect of toothpastes containing hydroxyapatite (nHAP), Zn-Mg-hydroxyapatite (nZnMgHAP), and fluorapatite (nFAP) nanocrystals on dentin hypersensitivity (DH) associated with noncarious cervical lesions.

Materials and methods: Thirty consenting volunteers aged 35-45 years with DH were enrolled in a double-blind, parallel study, randomly assigned to the nHAP group (n = 10), the nZnMgHAP group (n = 10), or the nFAP group (n = 10), and instructed to use the toothpaste twice daily for one month. The primary outcome was Schiff scores at baseline and after 2 and 4 weeks.

Results: All patients fulfilled the study requirements, and no adverse effects were registered. A reduction in DH was registered in 90%, 100%, and 50% of patients using nHAP, nZnMgHAP, and nFAP-containing toothpastes with effect sizes 2.52 (confidence interval [CI] 95%: 0.82, 4.14), 3.30 (CI 95%: 1.33, 5.20), and 1.44 (CI 95%: 0.09, 2.72), respectively. At 4 weeks, Schiff index scores decreased significantly in all groups compared to baseline.

Conclusions: nZnMgHAP may be considered a promising agent for DH management.

Keywords: Dentin sensitivity; nano-Zn-Mg-hydroxyapatite; nano-fluorapatite; nano-hydroxyapatite; noncarious cervical lesions.

Conflict of interest statement

There are no conflicts of interest.

Copyright: © 2022 Journal of International Society of Preventive and Community Dentistry.

Figures

Figure 1
Figure 1
Participant flow diagram
Figure 2
Figure 2
SEM images of dentin specimen surface before (A−C) and after (D−F) 21-day of toothpastes application of nHAP-containing toothpaste, nZnMgHAP-containing toothpaste, and nFAP-containing toothpaste, respectively

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