Association of asthma with coronary heart disease: A meta analysis of 11 trials

Lida Wang, Shuyan Gao, Mingdong Yu, Zhixin Sheng, Wei Tan, Lida Wang, Shuyan Gao, Mingdong Yu, Zhixin Sheng, Wei Tan

Abstract

Purpose: While the relationship of asthma and coronary heart disease (CHD) (a specific manifestation of cardiovascular disease) has not been described consistently, we tried to defined this relation and explore the influence of gender and asthma status (child- and adult-onset asthma) on this issue.

Methods: We searched published reports that described the relationship of asthma and CHD.

Results: Eleven trials were identified, covering 666,355 subjects. Asthma overall was significantly associated with CHD both for prospective trials (HR 1.34 [1.09,1.64], P = 0.005) and for retrospective trials(OR 1.29 [1.13,1.46], P = 0.001), when compared to individuals without asthma. Subgroup analysis split by gender indicated that females with asthma were significantly associated with CHD (HR 1.40 [1.20,1.62], P<0.001), but males with asthma were not significantly related with CHD (HR 1.19 [0.98,1.44], P = 0.07). For the four subgroups (Females with adult-onset asthma,males with adult-onset asthma,females with child-onset asthma,and males with child-onset asthma), pooled analysis of two trials indicated that only females with adult-onset asthma were significantly associated with CHD (HR 2.06 [1.32,3.19], P<0.001).

Conclusions: Our data indicated that asthma was associated with CHD, and the relationship between them seemed to derived mostly from females with adult-onset asthma. Considering the limits of our study, these findings should be taken with caution.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Fig 1. PRISMA flow diagram.
Fig 1. PRISMA flow diagram.
Fig 2. Meta-analysis of the association between…
Fig 2. Meta-analysis of the association between asthma and coronary heart disease(CHD).
HR, Hazard Ratio; OR Odds Ratio; CI, 95% confidence interval; Random, random-effects model.
Fig 3. Subgroup meta-analysis of the association…
Fig 3. Subgroup meta-analysis of the association between asthma and coronary heart disease(CHD) by sex (females and males).
HR, Hazard Ratios; CI, 95% confidence interval; Random, random-effects model.
Fig 4. Subgroup meta-analysis of the association…
Fig 4. Subgroup meta-analysis of the association between asthma and coronary heart disease(CHD) by sex and age of asthma onset (child- and adult-onset).
HR, Hazard Ratios; CI, 95% confidence interval; Random, random-effects model.

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