Residual brain injury after early discontinuation of cooling therapy in mild neonatal encephalopathy
Peter J Lally, Paolo Montaldo, Vânia Oliveira, Ravi Shankar Swamy, Aung Soe, Seetha Shankaran, Sudhin Thayyil, Peter J Lally, Paolo Montaldo, Vânia Oliveira, Ravi Shankar Swamy, Aung Soe, Seetha Shankaran, Sudhin Thayyil
Abstract
We examined the brain injury and neurodevelopmental outcomes in a prospective cohort of 10 babies with mild encephalopathy who had early cessation of cooling therapy. All babies had MRI and spectroscopy within 2 weeks after birth and neurodevelopmental assessment at 2 years. Cooling was prematurely discontinued at a median age of 9 hours (IQR 5-13) due to rapid clinical improvement. Five (50%) had injury on MRI or spectroscopy, and two (20%) had an abnormal neurodevelopmental outcome at 2 years. Premature cessation of cooling therapy in babies with mild neonatal encephalopathy does not exclude residual brain injury and adverse long-term neurodevelopmental outcomes. This study refers to babies recruited into the MARBLE study (NCT01309711, pre-results stage).
Keywords: encephalopathy; magnetic resonance; newborn; therapeutic hypothermia.
Conflict of interest statement
Competing interests: None declared.
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Source: PubMed