Role of adipose tissue in facial aging

Uwe Wollina, Reinhard Wetzker, Mohamed Badawy Abdel-Naser, Ilja L Kruglikov, Uwe Wollina, Reinhard Wetzker, Mohamed Badawy Abdel-Naser, Ilja L Kruglikov

Abstract

Age-dependent modification of the facial subcutaneous white adipose tissue (sWAT) connected with reduction of its volume, modification of collagen content and adhesion between dermal and adipose layers can significantly influence mechanical stability of the skin and cause the development of aging symptoms such as wrinkles. Typical aging appearance in facial skin is at least partly connected with special phenotypical features of facial preadipocytes and mature adipocytes. In this paper, we have discussed the possible roles of local inflammation, compartmental structure of facial sWAT and trans-differentiation processes such as beiging of white adipocytes and adipocyte-myofibroblast transition in facial skin aging.

Keywords: adipocyte-myofibroblast transition; adipocytes; adipose tissue; beiging; facial aging; inflammation; preadipocytes.

Conflict of interest statement

Disclosure ILK is the managing partner of Wellcomet GmbH. Wellcomet GmbH provided support in the form of salaries for ILK, but did not have any additional role in decision to publish or preparation of the manuscript. The commercial affiliation of ILK with Wellcomet GmbH does not alter the adherence to all journal policies on sharing data and materials. The other authors report no conflicts of interest in this work.

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