Comparison of saliva PCR assay versus rapid culture for detection of congenital cytomegalovirus infection
Swetha G Pinninti, Shannon A Ross, Masako Shimamura, Zdenek Novak, April L Palmer, Amina Ahmed, Robert W Tolan Jr, David I Bernstein, Marian G Michaels, Pablo J Sánchez, Karen B Fowler, Suresh B Boppana, National Institute on Deafness and Other Communication Disorders CMV and Hearing Multicenter Screening (CHIMES) Study, Swetha G Pinninti, Shannon A Ross, Masako Shimamura, Zdenek Novak, April L Palmer, Amina Ahmed, Robert W Tolan Jr, David I Bernstein, Marian G Michaels, Pablo J Sánchez, Karen B Fowler, Suresh B Boppana, National Institute on Deafness and Other Communication Disorders CMV and Hearing Multicenter Screening (CHIMES) Study
Abstract
As part of the CMV and Hearing Multicenter Screening (CHIMES) study, 72,239 newborns were screened for cytomegalovirus by rapid culture and real-time PCR of saliva samples. Of the 266 infants with congenital cytomegalovirus infection, discordance between rapid culture and PCR was observed in 14 children, and 13 were identified only by PCR, demonstrating the superiority of the PCR assay.
Conflict of interest statement
Potential conflicts of interest: All authors report no conflict of interest relevant to this manuscript.
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Source: PubMed