The effect of caffeine and albuterol on body composition and metabolic rate
Ann G Liu, Kenneth P Arceneaux 3rd, Jessica T Chu, Gregory Jacob Jr, Allyson L Schreiber, Russell C Tipton, Ying Yu, William D Johnson, Frank L Greenway, Stefany D Primeaux, Ann G Liu, Kenneth P Arceneaux 3rd, Jessica T Chu, Gregory Jacob Jr, Allyson L Schreiber, Russell C Tipton, Ying Yu, William D Johnson, Frank L Greenway, Stefany D Primeaux
Abstract
Objective: Caffeine and ephedrine was an effective combination therapy for weight loss until ephedrine was removed from the market due to safety concerns. This study investigated the combination of caffeine and albuterol as a possibly safer alternative to ephedrine.
Methods: In a series of experiments using cultured adipocytes, rat models, and humans, the effects of caffeine and albuterol on lipolysis, metabolic rate, food intake, and body composition were evaluated.
Results: Both caffeine and albuterol enhanced lipolysis in cultured adipocytes. Acute treatment of humans with caffeine and/or albuterol increased resting metabolic rate. Longer-term studies of rats revealed a trend for increased metabolic rate with albuterol treatment. There was increased lean mass gain concurrent with decreased fat mass gain with caffeine/albuterol treatment that was greater than albuterol treatment alone.
Conclusions: In rats, albuterol with caffeine produced significantly greater increases in lean body mass and reductions in fat mass without changes in food intake after 4-8 weeks of treatment. Since caffeine and albuterol are approved for the treatment of asthma in children and adolescents at the doses tested and change body composition without changing food intake, this combination may deserve further exploration for use in treating pediatric obesity.
© 2015 The Obesity Society.
Figures
Figure 2
Effect of caffeine and albuterol…
Figure 2
Effect of caffeine and albuterol on human metabolic rate. Values are means ±…
Figure 3
Impact of caffeine and albuterol…
Figure 3
Impact of caffeine and albuterol on body composition and metabolic rate in rats.…
Figure 4
The combination of caffeine and…
Figure 4
The combination of caffeine and albuterol reduces fat mass gain compared to albuterol…
- The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss.Liu AG, Smith SR, Fujioka K, Greenway FL. Liu AG, et al. Obesity (Silver Spring). 2013 Oct;21(10):1991-6. doi: 10.1002/oby.20416. Epub 2013 Jun 11. Obesity (Silver Spring). 2013. PMID: 23686786 Clinical Trial.
- Energy expenditure, body composition, and glucose metabolism in lean and obese rhesus monkeys treated with ephedrine and caffeine.Ramsey JJ, Colman RJ, Swick AG, Kemnitz JW. Ramsey JJ, et al. Am J Clin Nutr. 1998 Jul;68(1):42-51. doi: 10.1093/ajcn/68.1.42. Am J Clin Nutr. 1998. PMID: 9665095
- Comparative effects of caffeine and albuterol on the bronchoconstrictor response to exercise in asthmatic athletes.VanHaitsma TA, Mickleborough T, Stager JM, Koceja DM, Lindley MR, Chapman R. VanHaitsma TA, et al. Int J Sports Med. 2010 Apr;31(4):231-6. doi: 10.1055/s-0030-1247592. Epub 2010 Feb 10. Int J Sports Med. 2010. PMID: 20148372 Clinical Trial.
- Pharmacology of thermogenic drugs.Astrup A, Toubro S, Christensen NJ, Quaade F. Astrup A, et al. Am J Clin Nutr. 1992 Jan;55(1 Suppl):246S-248S. doi: 10.1093/ajcn/55.1.246s. Am J Clin Nutr. 1992. PMID: 1345887 Review.
- What do pharmacological approaches to obesity management offer? Linking pharmacological mechanisms of obesity management agents to clinical practice.Astrup A, Lundsgaard C. Astrup A, et al. Exp Clin Endocrinol Diabetes. 1998;106 Suppl 2:29-34. doi: 10.1055/s-0029-1212034. Exp Clin Endocrinol Diabetes. 1998. PMID: 9792479 Review.
- KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice.Kotańska M, Dziubina A, Szafarz M, Mika K, Reguła K, Bednarski M, Zygmunt M, Drabczyńska A, Sapa J, Kieć-Kononowicz K. Kotańska M, et al. PLoS One. 2020 Jun 18;15(6):e0229806. doi: 10.1371/journal.pone.0229806. eCollection 2020. PLoS One. 2020. PMID: 32555600 Free PMC article.
- A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline.Cornelius T, Schwartz JE, Balte P, Bhatt SP, Cassano PA, Currow D, Jacobs DR, Johnson M, Kalhan R, Kronmal R, Loehr L, O'Connor GT, Smith B, White WB, Yende S, Oelsner EC. Cornelius T, et al. Am J Epidemiol. 2020 Oct 1;189(10):1173-1184. doi: 10.1093/aje/kwaa059. Am J Epidemiol. 2020. PMID: 32286615 Free PMC article.
- Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO.Papukashvili D, Rcheulishvili N, Deng Y. Papukashvili D, et al. Nutrients. 2020 Jan 9;12(1):184. doi: 10.3390/nu12010184. Nutrients. 2020. PMID: 31936548 Free PMC article. Review.
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Adolescent
- Adult
- Albuterol / pharmacology
- Albuterol / therapeutic use*
- Animals
- Body Composition / drug effects
- Caffeine / pharmacology
- Caffeine / therapeutic use*
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Obesity / drug therapy*
- Rats
- Young Adult
- Caffeine
- Albuterol
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Figure 3
Impact of caffeine and albuterol…
Figure 3
Impact of caffeine and albuterol on body composition and metabolic rate in rats.…
Figure 4
The combination of caffeine and…
Figure 4
The combination of caffeine and albuterol reduces fat mass gain compared to albuterol…
- The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss.Liu AG, Smith SR, Fujioka K, Greenway FL. Liu AG, et al. Obesity (Silver Spring). 2013 Oct;21(10):1991-6. doi: 10.1002/oby.20416. Epub 2013 Jun 11. Obesity (Silver Spring). 2013. PMID: 23686786 Clinical Trial.
- Energy expenditure, body composition, and glucose metabolism in lean and obese rhesus monkeys treated with ephedrine and caffeine.Ramsey JJ, Colman RJ, Swick AG, Kemnitz JW. Ramsey JJ, et al. Am J Clin Nutr. 1998 Jul;68(1):42-51. doi: 10.1093/ajcn/68.1.42. Am J Clin Nutr. 1998. PMID: 9665095
- Comparative effects of caffeine and albuterol on the bronchoconstrictor response to exercise in asthmatic athletes.VanHaitsma TA, Mickleborough T, Stager JM, Koceja DM, Lindley MR, Chapman R. VanHaitsma TA, et al. Int J Sports Med. 2010 Apr;31(4):231-6. doi: 10.1055/s-0030-1247592. Epub 2010 Feb 10. Int J Sports Med. 2010. PMID: 20148372 Clinical Trial.
- Pharmacology of thermogenic drugs.Astrup A, Toubro S, Christensen NJ, Quaade F. Astrup A, et al. Am J Clin Nutr. 1992 Jan;55(1 Suppl):246S-248S. doi: 10.1093/ajcn/55.1.246s. Am J Clin Nutr. 1992. PMID: 1345887 Review.
- What do pharmacological approaches to obesity management offer? Linking pharmacological mechanisms of obesity management agents to clinical practice.Astrup A, Lundsgaard C. Astrup A, et al. Exp Clin Endocrinol Diabetes. 1998;106 Suppl 2:29-34. doi: 10.1055/s-0029-1212034. Exp Clin Endocrinol Diabetes. 1998. PMID: 9792479 Review.
- KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice.Kotańska M, Dziubina A, Szafarz M, Mika K, Reguła K, Bednarski M, Zygmunt M, Drabczyńska A, Sapa J, Kieć-Kononowicz K. Kotańska M, et al. PLoS One. 2020 Jun 18;15(6):e0229806. doi: 10.1371/journal.pone.0229806. eCollection 2020. PLoS One. 2020. PMID: 32555600 Free PMC article.
- A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline.Cornelius T, Schwartz JE, Balte P, Bhatt SP, Cassano PA, Currow D, Jacobs DR, Johnson M, Kalhan R, Kronmal R, Loehr L, O'Connor GT, Smith B, White WB, Yende S, Oelsner EC. Cornelius T, et al. Am J Epidemiol. 2020 Oct 1;189(10):1173-1184. doi: 10.1093/aje/kwaa059. Am J Epidemiol. 2020. PMID: 32286615 Free PMC article.
- Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO.Papukashvili D, Rcheulishvili N, Deng Y. Papukashvili D, et al. Nutrients. 2020 Jan 9;12(1):184. doi: 10.3390/nu12010184. Nutrients. 2020. PMID: 31936548 Free PMC article. Review.
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Adolescent
- Adult
- Albuterol / pharmacology
- Albuterol / therapeutic use*
- Animals
- Body Composition / drug effects
- Caffeine / pharmacology
- Caffeine / therapeutic use*
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Obesity / drug therapy*
- Rats
- Young Adult
- Caffeine
- Albuterol
- Full Text Sources
- Other Literature Sources
- Medical
NCBI Literature Resources
The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.
National Library of Medicine
8600 Rockville Pike
Bethesda, MD 20894
Figure 4
The combination of caffeine and…
Figure 4
The combination of caffeine and albuterol reduces fat mass gain compared to albuterol…
- The effect of leptin, caffeine/ephedrine, and their combination upon visceral fat mass and weight loss.Liu AG, Smith SR, Fujioka K, Greenway FL. Liu AG, et al. Obesity (Silver Spring). 2013 Oct;21(10):1991-6. doi: 10.1002/oby.20416. Epub 2013 Jun 11. Obesity (Silver Spring). 2013. PMID: 23686786 Clinical Trial.
- Energy expenditure, body composition, and glucose metabolism in lean and obese rhesus monkeys treated with ephedrine and caffeine.Ramsey JJ, Colman RJ, Swick AG, Kemnitz JW. Ramsey JJ, et al. Am J Clin Nutr. 1998 Jul;68(1):42-51. doi: 10.1093/ajcn/68.1.42. Am J Clin Nutr. 1998. PMID: 9665095
- Comparative effects of caffeine and albuterol on the bronchoconstrictor response to exercise in asthmatic athletes.VanHaitsma TA, Mickleborough T, Stager JM, Koceja DM, Lindley MR, Chapman R. VanHaitsma TA, et al. Int J Sports Med. 2010 Apr;31(4):231-6. doi: 10.1055/s-0030-1247592. Epub 2010 Feb 10. Int J Sports Med. 2010. PMID: 20148372 Clinical Trial.
- Pharmacology of thermogenic drugs.Astrup A, Toubro S, Christensen NJ, Quaade F. Astrup A, et al. Am J Clin Nutr. 1992 Jan;55(1 Suppl):246S-248S. doi: 10.1093/ajcn/55.1.246s. Am J Clin Nutr. 1992. PMID: 1345887 Review.
- What do pharmacological approaches to obesity management offer? Linking pharmacological mechanisms of obesity management agents to clinical practice.Astrup A, Lundsgaard C. Astrup A, et al. Exp Clin Endocrinol Diabetes. 1998;106 Suppl 2:29-34. doi: 10.1055/s-0029-1212034. Exp Clin Endocrinol Diabetes. 1998. PMID: 9792479 Review.
- KD-64-A new selective A2A adenosine receptor antagonist has anti-inflammatory activity but contrary to the non-selective antagonist-Caffeine does not reduce diet-induced obesity in mice.Kotańska M, Dziubina A, Szafarz M, Mika K, Reguła K, Bednarski M, Zygmunt M, Drabczyńska A, Sapa J, Kieć-Kononowicz K. Kotańska M, et al. PLoS One. 2020 Jun 18;15(6):e0229806. doi: 10.1371/journal.pone.0229806. eCollection 2020. PLoS One. 2020. PMID: 32555600 Free PMC article.
- A Dyadic Growth Modeling Approach for Examining Associations Between Weight Gain and Lung Function Decline.Cornelius T, Schwartz JE, Balte P, Bhatt SP, Cassano PA, Currow D, Jacobs DR, Johnson M, Kalhan R, Kronmal R, Loehr L, O'Connor GT, Smith B, White WB, Yende S, Oelsner EC. Cornelius T, et al. Am J Epidemiol. 2020 Oct 1;189(10):1173-1184. doi: 10.1093/aje/kwaa059. Am J Epidemiol. 2020. PMID: 32286615 Free PMC article.
- Attenuation of Weight Gain and Prevention of Associated Pathologies by Inhibiting SSAO.Papukashvili D, Rcheulishvili N, Deng Y. Papukashvili D, et al. Nutrients. 2020 Jan 9;12(1):184. doi: 10.3390/nu12010184. Nutrients. 2020. PMID: 31936548 Free PMC article. Review.
- Randomized Controlled Trial
- Research Support, N.I.H., Extramural
- Research Support, Non-U.S. Gov't
- Adolescent
- Adult
- Albuterol / pharmacology
- Albuterol / therapeutic use*
- Animals
- Body Composition / drug effects
- Caffeine / pharmacology
- Caffeine / therapeutic use*
- Cross-Over Studies
- Double-Blind Method
- Female
- Humans
- Male
- Middle Aged
- Obesity / drug therapy*
- Rats
- Young Adult
- Caffeine
- Albuterol
- Full Text Sources
- Other Literature Sources
- Medical
Source: PubMed