Recombinant human interleukin 5 is a selective activator of human eosinophil function

A F Lopez, C J Sanderson, J R Gamble, H D Campbell, I G Young, M A Vadas, A F Lopez, C J Sanderson, J R Gamble, H D Campbell, I G Young, M A Vadas

Abstract

Human rIL-5 was found to selectively stimulate morphological changes and the function of human eosinophils. This molecule is thus a prime candidate for the selective eosinophilia and eosinophil activation seen in disease.

References

    1. J Immunol. 1979 Apr;122(4):1228-36
    1. Cancer. 1984 Nov 15;54(10):2313-7
    1. N Engl J Med. 1980 Nov 13;303(20):1147-52
    1. Br J Haematol. 1980 Aug;45(4):523-34
    1. J Clin Invest. 1980 Dec;66(6):1265-73
    1. J Immunol. 1983 Feb;130(2):795-9
    1. J Cell Biol. 1985 Sep;101(3):1078-85
    1. Blood. 1986 Jan;67(1):37-45
    1. Proc Natl Acad Sci U S A. 1986 Feb;83(4):1055-9
    1. Heart Vessels. 1985 Aug;1(3):162-9
    1. J Exp Med. 1986 May 1;163(5):1085-99
    1. J Clin Invest. 1986 Nov;78(5):1220-8
    1. J Immunol. 1986 Nov 15;137(10):3290-4
    1. Nucleic Acids Res. 1986 Nov 25;14(22):9149-58
    1. Proc Natl Acad Sci U S A. 1987 May;84(9):2761-5
    1. Proc Natl Acad Sci U S A. 1987 Oct;84(19):6629-33
    1. Clin Exp Immunol. 1976 Jun;24(3):415-22
    1. Nature. 1977 Jul 28;268(5618):340-1
    1. J Clin Invest. 1984 May;73(5):1408-17
    1. Inflammation. 1979 Jul;3(3):261-72

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