COVID-19 Infection and Circulating ACE2 Levels: Protective Role in Women and Children

Elena Ciaglia, Carmine Vecchione, Annibale Alessandro Puca, Elena Ciaglia, Carmine Vecchione, Annibale Alessandro Puca

No abstract available

Keywords: ACE-angiotensin-converting enzyme; SARS-CoV; biomarker; infection-immunology; screening tools.

References

    1. Lu R, Zhao X, Li J, Niu P, Yang B, Wu H, et al. . Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding. Lancet. (2020) 395:565–74. 10.1016/S0140-6736(20)30251-8
    1. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, et al. . Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation. Science. (2020) 367:1260–3. 10.1126/science.abb2507
    1. Hamming I, Timens W, Bulthuis ML, Lely AT, Navis G, van Goor H, et al. . Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol. (2004) 203:631–7. 10.1002/path.1570
    1. Xu H, Zhong L, Deng J, Peng J, Dan H, Zeng X, et al. . High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa. Int J Oral Sci. (2020) 12. 10.1038/s41368-020-0074-x
    1. Li W, Moore MJ, Vasilieva N, Sui J, Wong SK, Berne MA, et al. . Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature. (2003) 426:450–4: 10.1038/nature02145
    1. Nie Y, Wang P, Shi X, Wang G, Chen J, Zheng A, et al. . Highly infectious SARS-CoV pseudotyped virus reveals the cell tropism and its correlation with receptor expression. Biochem Biophys Res Commun. (2004) 321:994–1000. 10.1016/j.bbrc.2004.07.060
    1. Hofmann H, Pyrc K, van der Hoek L, Geier M, Berkhout B, Pöhlmann S. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci USA. (2005) 102:7988–93. 10.1073/pnas.0409465102
    1. Kuba K, Imai Y, Rao S, Gao H, Guo F, Guan B, et al. . A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med. (2005) 11:875–9. 10.1038/nm1267
    1. Heurich A, Hofmann-Winkler H, Gierer S, Liepold T, Jahn O, Pöhlmann S. TMPRSS2 and ADAM17 Cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein. J Virol. (2013). 88:1293–307. 10.1128/JVI.02202-13
    1. Yang P, Gu H, Zhao Z, Wang W, Cao B, Lai C, et al. . Angiotensin-converting enzyme 2 (ACE2) mediates influenza H7N9 virus-induced acute lung injury. Sci Rep. (2014) 4:7027. 10.1038/srep07027
    1. Hemnes AR, Rathinasabapathy A, Austin EA, Brittain EL, Carrier EJ, Chen X, et al. . A potential therapeutic role for angiotensin converting enzyme 2 in human pulmonary arterial hypertension. Eur Respir J. (2018) 51:1702638. 10.1183/13993003.02638-2017
    1. Rice GI, Jones AL, Grant PJ, Carter AM, Turner AJ, Hooper NM. Circulating activities of angiotensin-converting enzyme, its homolog, angiotensin-converting enzyme 2, and neprilysin in a family study. Hypertension. (2006) 48:914–92. 10.1161/01.HYP.0000244543.91937.79
    1. Zhao Y, Zhao Z, Wang Y, Zhou Y, Ma Y, Zuo W. Single-cell RNA expression profiling of ACE2, the putative receptor of Wuhan 2019-nCoV. bioRxiv. (2020) 919985. 10.1101/2020.01.26
    1. Zhang Q, Cong M, Wang N, Li X, Zhang H, Zhang K, et al. . Association of angiotensin-converting enzyme 2 gene polymorphism and enzymatic activity with essential hypertension in different gender: a case-control study. Medicine. (2018) 97:e12917. 10.1097/MD.0000000000012917
    1. da Silva JS, Gabriel-Costa D, Wang H, Ahmad S, Sun X, Varagic J, et al. . Blunting of cardioprotective actions of estrogen in female rodent heart linked to altered expression of cardiac tissue chymase and ACE2. J Renin Angiotensin Aldosterone Syst. (2017) 18:1–4. 10.1177/1470320317722270
    1. Bénéteau-Burnat B, Baudin B, Morgant G, Baumann FC, Giboudeau J. Serum angiotensin-converting enzyme in healthy sarcoidotic children: comparison with the reference interval for adults. J. Clin. Chem. (1990) 36:344–6. 10.1093/clinchem/36.2.344
    1. Guan WJ, Ni ZY, Hu Y, Liang W, Ou C, He J, et al. Clinical characteristics of coronavirus disease 2019 in China. N Engl J Med. (2020). 10.1056/NEJMoa2002032. [Epub ahead of print].
    1. Day CW, Baric R, Cai SX, Frieman M, Kumaki Y, Morrey JD, et al. . A new mouse-adapted strain of SARS-CoV as a lethal model for evaluating antiviral agents in vitro and in vivo. Virology. (2009) 395:210–2. 10.1016/j.virol.2009.09.023
    1. Ghadhanfar E, Alsalem A, Al-Kandari S, Naser J, Babiker F, Al-Bader M. The role of ACE2, angiotensin-(1–7) and Mas1 receptor axis in glucocorticoid-induced intrauterine growth restriction. Reprod Biol Endocrinol. (2017) 15:97. 10.1186/s12958-017-0316-8
    1. Dong Y, Mo X, Hu Y, Qi X, Jiang F, Jiang Z, et al. . Epidemiological characteristics of 2143. pediatric patients with 2019 coronavirus disease in China. Pediatrics. (2020). e20200702. 10.1542/peds.2020-0702
    1. Li LJ, Zhang FB, Liu SY, Tian YH, Le F, Wang LY, et al. . Human sperm devoid of germinal angiotensin-converting enzyme is responsible for total fertilization failure and lower fertilization rates by conventional in vitro fertilization. Biol Reprod. (2014) 90:125. 10.1095/biolreprod.113.114827

Source: PubMed

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