Sleep and mood during hospitalization for high-dose chemotherapy and hematopoietic rescue in pediatric medulloblastoma
Danielle M Graef, Valerie McLaughlin Crabtree, Deo Kumar Srivastava, Chenghong Li, Michele Pritchard, Pamela S Hinds, Belinda Mandrell, Danielle M Graef, Valerie McLaughlin Crabtree, Deo Kumar Srivastava, Chenghong Li, Michele Pritchard, Pamela S Hinds, Belinda Mandrell
Abstract
Objective: Disrupted sleep is common in pediatric cancer, which is associated with psychological distress and may impact neural recovery. Information regarding sleep during pediatric brain tumor treatment is limited. This study aimed to describe objective sleep-wake patterns and examine the sleep-mood relation in youth hospitalized for intensive chemotherapy and stem cell rescue.
Methods: Participants included 37 patients (M age = 9.6 ± 4.2 years) enrolled on a medulloblastoma protocol (SJMB03) and their parents. Respondents completed a mood disturbance measure on 3 days, and patients wore an actigraph for 5 days as an objective estimate of sleep-wake patterns. General linear mixed models examined the relation between nocturnal sleep and next-day mood, as well as mood and that night's sleep.
Results: Sleep duration was deficient, sleep efficiency was poor, and daytime napping was common, with large between-subjects variability. There were minimal mood concerns across all days. The sleep and next-day mood relationship was nonsignificant (P > .05). Greater parent-reported child mood disturbance on day 2 was associated with decreased same-night sleep (P < .001) and greater patient-reported mood disturbance was associated with greater same-night sleep latency (P = .036).
Conclusions: Patients with medulloblastoma are vulnerable to disturbed sleep during hospitalization, and mood may be an important correlate to consider. Sleep and mood are modifiable factors that may be targeted to maximize daytime functioning.
Keywords: brain tumor; cancer; hospitalization; mood; oncology; pediatric medulloblastoma; sleep.
Conflict of interest statement
CONFLICT OF INTEREST
All Authors disclose no affiliations or other areas of conflict of interest considered to be relevant and important with any organization that to any author’s knowledge has a direct interest in the subject matter discussed.
Copyright © 2018 John Wiley & Sons, Ltd.
Source: PubMed