Epidural dexmedetomidine infusion for perioperative analgesia in patients undergoing abdominal cancer surgery: randomized trial

Diab Fuad Hetta, Khaled Mohamed Fares, Abualauon Mohamed Abedalmohsen, Amani Hassan Abdel-Wahab, Ghada Mohammed Abo Elfadl, Wesam Nashat Ali, Diab Fuad Hetta, Khaled Mohamed Fares, Abualauon Mohamed Abedalmohsen, Amani Hassan Abdel-Wahab, Ghada Mohammed Abo Elfadl, Wesam Nashat Ali

Abstract

Objective: To assess the postoperative analgesic efficacy of epidural dexmedetomidine added to bupivacaine infusion for patients undergoing major abdominal cancer surgery.

Methods: Patients scheduled for major upper abdominal cancer surgery were allocated to group bupivacaine (n =32), in which patients received epidural bupivacaine infusion (6 mL/h bupivacaine 0.1%) for 48 hours postoperatively, or group bupivacaine + dexmedetomidine (n=32), in which patients received epidural dexmedetomidine added to bupivacaine infusion (6 mL/h of bupivacaine 0.1% + dexmedetomidine, 0.5 µg/mL) for 48 hours postoperatively. The cumulative morphine consumption, the time to first analgesic request, and the VAS pain score were evaluated.

Results: The cumulative morphine consumption was significantly reduced in group bupivacaine + dexmedetomidine compared with group bupivacaine: mean ± SD of 10.40±5.16 mg vs 23.23±8.37 mg with an estimated difference (95% CI) of -12.83 (-16.43, -9.24), (P<0.001). The time to the first analgesic demand was significantly delayed in group bupivacaine + dexmedetomidine compared with group bupivacaine: median (IQR) of 6 (1.75, 8.25) h vs 1 (0, 4)h, (P<0.001). The mean collapsed over time of overall VAS pain scores at rest and movement was significantly reduced in group bupivacaine + dexmedetomidine compared with group bupivacaine : mean ± SE of 1.6±0.08 vs 2.38±0.08 with an estimated difference (95% CI) of -0.8 (-1, -0.86), (P<0.001), and mean ± SE of 2.17±0.07 vs 3.25±0.07 with an estimated difference (95% CI) of -1.1 (-1.27, - 0.89), (P<0.001), respectively.

Conclusion: Epidural infusion of dexmedetomidine added to bupivacaine for patients undergoing major abdominal cancer surgery significantly reduced morphine consumption, delayed time to first analgesic supplementation, and decreased pain intensity during the first 48 hours postoperatively without harmful derangement on hemodynamics.

Keywords: dexmedetomidine; epidural; postoperative pain.

Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flow diagram of patients Abbreviations: Group B, bupivacaine group; Group BD, bupivacaine + dexmedetomidine group.
Figure 2
Figure 2
Intraoperative blood pressure. Notes: *P<0.05, considered statistically significant. End, end of surgery. Abbreviations: BP, blood pressure; DBP, diastolic blood pressure; Group B, bupivacaine group; Group BD, bupivacaine + dexmedetomidine group; SBP, systolic blood pressure.
Figure 3
Figure 3
Intraoperative heart rate. Notes: *P<0.05, considered statistically significant. End, end of surgery. Abbreviations: Group B, bupivacaine group; Group BD, bupivacaine + dexmedetomidine group; HR, heart rate.
Figure 4
Figure 4
Postoperative blood pressure. Note: *P<0.05, considered statistically significant. Abbreviations: DBP, diastolic blood pressure; Group B, bupivacaine group; Group BD, bupivacaine + dexmedetomidine group; SBP, systolic blood pressure.
Figure 5
Figure 5
Postoperative HR. Note: *P<0.05, considered statistically significant. Abbreviations: Group B, bupivacaine group; Group BD, bupivacaine + dexmedetomidine group; HR, heart rate.

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