Effect of Repetitive Transcranial Magnetic Stimulation on Cigarette Smoking in Patients with Schizophrenia

Wanli Huang, Fang Shen, Jiangtao Zhang, Baoping Xing, Wanli Huang, Fang Shen, Jiangtao Zhang, Baoping Xing

Abstract

Background: The high smoking rate among patients with schizophrenia is an important public health problem, and researchers have been studying how to change the status quo.

Objective: We investigated the effects of high frequency (10Hz) repetitive transcranial magnetic stimulation on the amount of cigarette smoking in patients with schizophrenia.

Method: This study enrolled 37 male patients with schizophrenia who were at a stable stage of treatment. Patients were randomly divided into a treatment group (n=19) and a control group (n=18). The treatment group received repetitive transcranial magnetic stimulation (rTMS) on the left prefrontal dorsolateral cortex (DLPFC), and the control group received placebo treatment. The number of cigarettes smoked were recorded at 7 days before treatment, during the course of treatment (i.e. for 21 days), and 3 weeks after treatment had ended. Assessments using the Positive and Negative Syndrome Scale (PANSS), Wisconsin Card Sorting Test (WCST), and Montgomery Asberg Depression Rating Scale (MADRS) were applied before and after treatment.

Result: Compared to the control group, the number of cigarettes smoked in the treatment group showed a statistically significant reduction in the first week after treatment. However, there was no significant correlation between the scores on PANSS, WCST and MADRS and the number of cigarettes smoked before and after treatment in both groups.

Discussion: High frequency (10Hz) repetitive transcranial magnetic stimulation on the left prefrontal cortex can reduce the number of cigarettes smoked in patients with schizophrenia.

Keywords: Repetitive transcranial magnetic stimulation; cigarette smoking; schizophrenia.

Figures

Figure 1.
Figure 1.
Enrollment of obsessive-compulsive disorder and healthy controls

References

    1. Wen XZ, Chen WQ, Lu CY, Zhang CX, Luo JY, Deng XQ, et al. [Knowledge and belief related to smoking and health and their association with smoking behaviors among secondary school students]. Zhongguo Gong Gong Wei Sheng. 2005; 21(6): 756-758. Chinese. doi:
    1. Schneider CE, White T, Hass J, Geisler Daniel, Wallace Stuart R, Roessner Veit, et al. Smoking status as a potential confounder in the study of brain structure in schizophrenia. J Psychiatr Res. 2014; 50: 84-91. doi:
    1. de Leon J, Diaz FJ. A meta-analysis of worldwide studies demonstrates an association between schizophrenia and tobacco smoking behaviors. Schizophr Res. 2005; 76(2-3): 135-157. doi:
    1. Xu YM, Chen HH, Li F, Deng F, Liu XB, Yang HC, et al. Prevalence and correlates of cigarette smoking among Chinese schizophrenia inpatients receiving antipsychotic mono-therapy. PloS One. 2014; 9(2): e88478 doi:
    1. Li X, Hartwell KJ, Owens M, Lematty T, Borckardt JJ, Hanlon CA, et al. Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving. Biol Psychiatry. 2013; 73(8): 714-720. doi:
    1. Wing VC, Bacher I, Wu BS, Daskalakis Zafiris J, George Tony P, et al. High frequency repetitive transcranial magnetic stimulation reduces tobacco craving in schizophrenia. Schizophr Res. 2012; 139(1-3): 264-266. doi:
    1. Wing VC, Barr MS, Wass CE, Lipsman Nir, Lozano Andres M, Daskalakis Zafiris J, et al. Brain stimulation methods to treat tobacco addiction. Brain Stimul. 2013; 6(3): 221-230. doi:
    1. American Psychological Association. Diagnostic and Statistical Manual of Mental Disorder- IV. Washington, DC: American Psychiatric Association; 1994
    1. Si TM, Yang JZ, Shu L, Wang XL, Kong QM, Zhou M, et al. [The reliability, validity of PANSS and its implication]. Zhongguo Xin Li Wei Sheng Za Zhi. 2004; 18(1): 45-47. Chinese. doi:
    1. Liu H, Zhang HY, Xiao WD, Liu Q, Wang G, Chen JX, et al. [Comparison of 5 assessment tools for evaluating depressive symptom in patients with schizophrenia]. Zhongguo Xin Li Wei Sheng Za Zhi. 2015; 8: 570-575. Chinese. doi:
    1. Featherstone RE, Siegel SJ. The role of nicotine in schizophrenia. Int Rev Neurobiol. 2015; 124: 23-78. doi:
    1. Olincy A, Young DA, Freedman R. Increased levels of the nicotine metabolite cotinine in schizophrenic smokers compared to other smokers. Biological Psychiatry, 1997; 42(1): 1-5. doi:
    1. Kelly C, McCreadie R. Cigarette smoking and schizophrenia. Adv Psychiatr Treat. 2000; 6(5): 327-331. doi:
    1. Zhang XY, Liang J, Xiu MH, Hong X, He J, Cheng W, et al. Cigarette smoking in male patients with chronic schizophrenia in a Chinese population: prevalence and relationship to clinical phenotypes. PloS One. 2012; 7(2): e30937 doi:
    1. Lo S, Heishman SJ, Raley H, Wright K, Wehring HJ, Moolchan ET, et al. Tobacco craving in smokers with and without schizophrenia. Schizophr Res. 2011; 127(1-3): 241-245. doi:
    1. Di Chiara G. Role of dopamine in the behavioural actions of nicotine related to addiction. Eur J Pharmacol. 2000; 393(1-3): 295-314. doi:
    1. Berardelli A, Inghilleri M, Rothwell JC, Romeo S, Currà A, Gilio F, et al. Facilitation of muscle evoked responses after repetitive cortical stimulation in man. Exp Brain Res. 1998; 122(1): 79-84
    1. Cooke SF, Bliss TV. Plasticity in the human central nervous system. Brain. 2006; 129(7): 1659-1673. doi:
    1. Krain AL, Wilson AM, Arbuckle R, Castellanos F Xavier, Milham Michael P, et al. Distinct neural mechanisms of risk and ambiguity: a meta-analysis of decision-making. NeuroImage. 2006; 32(1): 477-484. doi:
    1. Rachid F, Bertschy G. Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of depression: a critical appraisal of the last 10 years. Neurophysiol Clin. 2006; 36(3): 157-183. doi:
    1. Goyal N, Nizamie SH, Desarkar P. Efficacy of adjuvant high frequency repetitive transcranial magnetic stimulation on negative and positive symptoms of schizophrenia: preliminary results of a double-blind sham-controlled study. J Neuropsychiatry Clin Neurosci. 2007; 19(4): 464-467. doi:
    1. Shi C, Yu X, Cheung EF, Shum David H K, Chan Raymond C K, et al. Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: a meta-analysis. Psychiatry Res. 2014; 215(3): 505-513. doi:
    1. Huber TJ, Schneider U, Rollnik J. Gender differences in the effect of repetitive transcranial magnetic stimulation in schizophrenia. Psychiatry Res. 2003; 120(1): 103-105. doi:

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