Comparison of Efficacy of Autologous Platelet-Rich Fibrin versus Unna's Paste Dressing in Chronic Venous Leg Ulcers: A Comparative Study

G Yuvasri, Reena Rai, G Yuvasri, Reena Rai

Abstract

Background: Chronic venous leg ulcers are difficult to treat and recurrences are common. Among various modalities of treatment, platelet-rich fibrin (PRF) has shown promising results in ulcer healing by providing necessary growth factors. Unna's paste dressing has also proven to enhance wound healing.

Aim: The aim of this study is to compare the efficacy of autologous PRF versus Unna's paste dressing in chronic venous leg ulcer patients and to compare the mean reduction in ulcer area at the end of 4 weeks.

Materials and methods: Twenty patients with chronic venous leg ulcers were randomly divided into two groups. Group 1: Patients received PRF dressing which was repeated every week for 4 weeks. Group 2: Patients received Unna's paste dressing once a week for 4 weeks. The ulcer size was assessed with the help of photographs, and ulcer area was measured.

Results: The mean reduction in the area of the ulcer size in the PRF group was 86.03% and in the Unna's paste group was 71.97%, which was not statistically significant with a P value of 0.223.

Conclusion: We conclude that though there was no statistical significance between the groups, PRF showed a significant reduction in ulcer size.

Keywords: Platelet-rich fibrin; Unna's paste; venous leg ulcer.

Conflict of interest statement

There are no conflicts of interest.

Copyright: © 2020 Indian Dermatology Online Journal.

Figures

Figure 1
Figure 1
Bar diagram showing percentage of size reduction with platelet-rich fibrin and Unna's paste dressing
Figure 2
Figure 2
(a) Patient 1: A 54-year-old female with a venous ulcer over the left leg before treatment with platelet-rich fibrin dressing; (b) 80% improvement after 4 weeks of treatment with platelet-rich fibrin dressing
Figure 3
Figure 3
(a) Patient 2: A 62-year-old male presented with an ulcer over the right leg before treatment with platelet-rich fibrin dressing, (b) showing complete closure after 4 weeks of treatment with platelet-rich fibrin dressing
Figure 4
Figure 4
(a) Patient 3: A 50-year-old female with an ulcer over the right leg before treatment with Unna's paste dressing; (b) 90% improvement after 4 weeks of treatment with Unna's paste dressing
Figure 5
Figure 5
(a) Patient 4- 49-year-old male with ulcer near right lateral malleolus before treatment with Unna's paste dressing, (b) showing 70% improvement after 4 weeks of treatment with Unna's paste dressing

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Source: PubMed

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