Hepatic resection alone versus in combination with pre- and post-operative transarterial chemoembolization for the treatment of hepatocellular carcinoma: A systematic review and meta-analysis

Xingshun Qi, Lei Liu, Diya Wang, Hongyu Li, Chunping Su, Xiaozhong Guo, Xingshun Qi, Lei Liu, Diya Wang, Hongyu Li, Chunping Su, Xiaozhong Guo

Abstract

Background and aims: The prognosis of hepatocellular carcinoma (HCC) treated with hepatic resection may be improved by the adjunctive use of transarterial chemoembolization (TACE). This study aimed to systematically compare the outcomes between hepatic resection with and without TACE groups.

Methods: All relevant randomized controlled trials (RCTs) and non-RCTs were searched by the PubMed, EMBASE, and Cochrane Library databases. Overall survival (OS) and disease-free survival (DFS) were two major outcomes. Meta-analyses were performed according to the timing of TACE (pre- or post-operative TACE). Subgroup analyses were also performed. Hazard ratios (HRs) with 95% confidence intervals (95%CIs) were calculated.

Results: Overall, 55 papers were included (14 RCTs and 41 non-RCTs). Overall meta-analyses demonstrated that OS and DFS were statistically similar between hepatic resection with and without pre-operative TACE groups (HR = 1.01, 95%CI = 0.87-1.19, P = 0.87; HR = 0.91, 95%CI = 0.82-1.01, P = 0.07). Subgroup analyses of RCTs or non-RCTs showed that OS and DFS remained statistically similar between hepatic resection with and without pre-operative TACE groups. Subgroup analysis of incomplete or no tumor necrosis showed that OS was worse in hepatic resection with pre-operative TACE group than in hepatic resection without pre-operative TACE group. By contrast, subgroup analysis of complete tumor necrosis showed that DFS was better in hepatic resection with pre-operative TACE group than in hepatic resection without pre-operative TACE group.Overall meta-analyses demonstrated that OS and DFS were better in hepatic resection with post-operative TACE group than in hepatic resection without post-operative TACE group (HR = 0.85, 95%CI = 0.72-1.00, P = 0.06; HR = 0.83, 95%CI = 0.73-0.94, P = 0.004). Subgroup analyses of RCTs, vascular invasion, or large HCC showed that OS and DFS remained better in hepatic resection with post-operative TACE group than in hepatic resection without post-operative TACE group. By contrast, subgroup analyses of non-RCTs, no vascular invasion, or small HCC showed that OS and DFS were statistically similar between the two groups.

Conclusions: Post-operative TACE, rather than pre-operative TACE, may be considered as an adjunctive treatment option for HCC treated with hepatic resection.

Keywords: hepatic resection; hepatocellular carcinoma; recurrence; survival; transarterial chemoembolization.

Conflict of interest statement

CONFLICTS OF INTEREST

The authors report no declarations of interest.

Figures

Figure 1. Flowchart of study inclusion
Figure 1. Flowchart of study inclusion
Figure 2. Forest plots comparing the overall…
Figure 2. Forest plots comparing the overall survival between hepatic resection with and without pre-operative TACE groups
Figure 3. Forest plots comparing the disease-free…
Figure 3. Forest plots comparing the disease-free survival between hepatic resection with and without pre-operative TACE groups
Figure 4. Forest plots comparing the overall…
Figure 4. Forest plots comparing the overall survival between hepatic resection with and without post-operative TACE groups
Figure 5. Forest plots comparing the disease-free…
Figure 5. Forest plots comparing the disease-free survival between hepatic resection with and without post-operative TACE groups
Figure 6. Forest plots comparing the rate…
Figure 6. Forest plots comparing the rate of being free of recurrence between hepatic resection with and without post-operative TACE groups

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