Plasma progesterone and 17-hydroxyprogesterone in normal men and children with congenital adrenal hyperplasia

C A Strott, T Yoshimi, M B Lipsett, C A Strott, T Yoshimi, M B Lipsett

Abstract

Plasma 17-hydroxyprogesterone (17-OHP) concentrations in normal men averaged 0.094 mug/100 ml. Studies using suppressive doses of androgens and glucocorticoids showed that 90% of the 17-OHP originated from the Leydig cell. The 17-OHP production rate was 1.8 mg/24 hr. Plasma 17-OHP has a marked circadian variation, the 8 p.m. values being only 40% of the 8 a.m. values. Plasma luteinizing hormone measured in the same samples did not vary. The adrenal cortex has the capacity to synthesize and secrete 17-OHP and progesterone since adrenocorticotrophic hormone (ACTH) caused a fourfold increase in these plasma steroids. In children with congenital adrenal hyperplasia, plasma 17-OHP levels were 50-200 times those of normal men and plasma progesterone was increased 6- to 10-fold over normal men.

References

    1. J Clin Endocrinol Metab. 1965 Nov;25(11):1441-50
    1. Bull Soc Chim Biol (Paris). 1965;47(11):2145-61
    1. J Clin Endocrinol Metab. 1966 May;26(5):573-6
    1. J Clin Invest. 1967 Feb;46(2):248-55
    1. J Clin Endocrinol Metab. 1966 Dec;26(12):1297-302
    1. J Clin Endocrinol Metab. 1967 Jan;27(1):79-88
    1. J Clin Endocrinol Metab. 1967 Mar;27(3):448-51
    1. J Clin Endocrinol Metab. 1967 May;27(5):663-70
    1. Nature. 1967 Aug 19;215(5103):857
    1. J Clin Endocrinol Metab. 1968 Apr;28(4):519-34
    1. Steroids. 1968 Apr;11(4):527-40
    1. J Clin Endocrinol Metab. 1968 Jul;28(7):1085-8
    1. J Clin Endocrinol Metab. 1968 Oct;28(10):1426-30
    1. Steroids. 1968 Jul;12(1):151-63
    1. J Clin Endocrinol Metab. 1957 Jul;17(7):870-7
    1. J Clin Endocrinol Metab. 1961 Jul;21:765-78
    1. J Endocrinol. 1960 Apr;20:157-62
    1. J Clin Endocrinol Metab. 1961 Dec;21:1534-42
    1. J Endocrinol. 1965 Feb;31:235-44
    1. J Clin Endocrinol Metab. 1959 Nov;19:1399-404

Source: PubMed

Sponsors and Collaborators

Medical Conditions

Drug Interventions

3
Subscribe