Methylphenidate selectively modulates one sub-component of the no-go P3 in pediatric ADHD medication responders
Ida Emilia Aasen, Geir Øgrim, Juri Kropotov, Jan Ferenc Brunner, Ida Emilia Aasen, Geir Øgrim, Juri Kropotov, Jan Ferenc Brunner
Abstract
Methylphenidate (MPH) has been shown to modulate the amplitude of the no-go P3 component of the event-related potential (ERP; Øgrim, Aasen, & Brunner, 2016). Using group independent component analysis, the no-go P3 from a cued go/no-go task has been separated into two sub-components (Brunner et al., 2013). This study investigated whether sub-components of the no-go P3 could be identified in children with ADHD, and how MPH modulates their amplitudes. ERPs were registered twice (on/off MPH) in 57 children with ADHD classified as medication responders in a four-week medication trial. Two no-go P3 sub-components were identified. In the MPH session, the amplitude of one sub-component, the IC P3no-goearly (mean latency 378 ms, with a central distribution), was significantly larger than at baseline, whereas the other sub-component, the IC P3no-golate (mean latency 428 ms, with a centro-frontal distribution), was not significantly affected. These results add to the literature documenting that the no-go P3 consists of two overlapping phenomena with different functional correlates.
Trial registration: ClinicalTrials.gov NCT02695355.
Keywords: ADHD; Cued go/no-go; ICA; MPH; No-go P3.
Copyright © 2018 The Author(s). Published by Elsevier B.V. All rights reserved.
Source: PubMed