Results of NC-6300 (Nanoparticle Epirubicin) in an Expansion Cohort of Patients with Angiosarcoma

Abstract

Background: NC-6300 is a novel epirubicin (EPI) drug conjugated polymeric micelle developed using cutting-edge micellar nanoparticle technology. The nanoparticle epirubicin conjugates EPI to a polymer via a pH-sensitive linker which enables the selective EPI release into tumor. Tumor activity was observed in a monotherapy phase Ib trial, where two of two patients with angiosarcoma achieved a partial response. To further explore the activity of NC-6300 in angiosarcoma, an expansion cohort was undertaken.

Methods: Ten patients with angiosarcoma were enrolled in the expansion cohort. Patients were dosed using the recommended dose of 150 mg/m2 intravenously (IV) once every 3 weeks. The primary endpoint was progression-free survival.

Results: The most common adverse events (AEs) of any grade, regardless of the causal relationship with NC-6300, were neutropenia (90%), fatigue, and thrombocytopenia (60% each) and nausea (50%). The most common grades 3 and 4 AEs were neutropenia (80%), thrombocytopenia (40%), and anemia and leukopenia (20% each). The median progression-free survival (mPFS) for all subjects was 5.4 months. The mPFS was 3.8 months in subjects with prior anthracycline treatment and 8.2 months in subjects without prior anthracycline treatment.

Conclusion: NC-6300 was well tolerated, showing promising activity in angiosarcoma patients without prior anthracycline treatment. NC-6300 warrants further investigation (ClinicalTrials.gov Identifier: NCT03168061).

Keywords: NC-6300; angiosarcoma; epirubicin; metastatic; nanoparticle; soft tissue sarcoma; unresectable.

© The Author(s) 2022. Published by Oxford University Press.

Figures

Figure 1.

Progression-free survival (N = 10). The overall mPFS for all subjects included in the trial was 5.4 months. The mPFS was 3.8 months in subjects with prior anthracycline treatment and 8.2 months for subjects without prior anthracycline treatment.

Figure 2.

Spider plot of maximal change in tumor size in angiosarcoma population (N = 10). Partial response was observed in 3 patients without prior anthracycline treatment, yielding an objective response rate (ORR) of 30%.