Early mobilization protocols for critically ill pediatric patients: systematic review

Taila Cristina Piva, Renata Salatti Ferrari, Camila Wohlgemuth Schaan, Taila Cristina Piva, Renata Salatti Ferrari, Camila Wohlgemuth Schaan

Abstract

Objective: To describe the existing early mobilization protocols in pediatric intensive care units.

Methods: A systematic literature review was performed using the databases MEDLINE®, Embase, SciELO, LILACS and PeDRO, without restrictions of date and language. Observational and randomized and nonrandomized clinical trials that described an early mobilization program in patients aged between 29 days and 18 years admitted to the pediatric intensive care unit were included. The methodological quality of the studies was evaluated using the Newcastle-Ottawa Scale, Methodological Index for Non-Randomized Studies and the Cochrane Collaboration.

Results: A total of 8,663 studies were identified, of which 6 were included in this review. Three studies described the implementation of an early mobilization program, including activities such as progressive passive mobilization, positioning, and discussion of mobilization goals with the team, in addition to contraindications and interruption criteria. Cycle ergometer and virtual reality games were also used as resources for mobilization. Four studies considered the importance of the participation of the multidisciplinary team in the implementation of early mobilization protocols.

Conclusion: In general, early mobilization protocols are based on individualized interventions, depending on the child's development. In addition, the use of a cycle ergometer may be feasible and safe in this population. The implementation of institutional and multidisciplinary protocols may contribute to the use of early mobilization in pediatric intensive care units; however, studies demonstrating the efficacy of such intervention are needed.

Trial registration: ClinicalTrials.gov NCT02958124 NCT02209935.

Conflict of interest statement

Conflicts of interest: None.

Figures

Figure 1
Figure 1
Flowchart of the studies included in the systematic review.

References

    1. Bone MF, Feinglass JM, Goodman DM. Risk factors for acquiring functional and cognitive disabilities during admission to a PICU*. Pediatr Crit Care Med. 2014;15(7):640–648.
    1. Namachivayam P, Shann F, Shekerdemian L, Taylor A, van Sloten I, Delzoppo C, et al. Three decades of pediatric intensive care: Who was admitted, what happened in intensive care, and what happened afterward. Pediatr Crit Care Med. 2010;11(5):549–555.
    1. Rennick JE, Childerhose JE. Redefining success in the PICU: new patient populations shift targets of care. Pediatrics. 2015;135(2):e289–e291.
    1. Pereira GA, Schaan CW, Ferrari RS. Functional evaluation of pediatric patients after discharge from the intensive care unit using the Functional Status Scale. Rev Bras Ter Intensiva. 2017;29(4):460–465.
    1. Zorowitz RD. ICU-acquired weakness: a rehabilitation perspective of diagnosis, treatment, and functional management. Chest. 2016;150(4):966–971.
    1. Herrup EA, Wieczorek B, Kudchadkar SR. Characteristics of postintensive care syndrome in survivors of pediatric critical illness: A systematic review. World J Crit Care Med. 2017;6(2):124–134.
    1. De Jonghe B, Bastuji-Garin S, Sharshar T, Outin H, Brochard L. Does ICU-acquired paresis lengthen weaning from mechanical ventilation. Intensive Care Med. 2004;30(6):1117–1121.
    1. Gosselink R, Bott J, Johnson M, Dean E, Nava S, Norrenberg M, et al. Physiotherapy for adult patients with critical illness: recommendations of the European Respiratory Society and European Society of Intensive Care Medicine Task Force on Physiotherapy for Critically Ill Patients. Intensive Care Med. 2008;34(7):1188–1199.
    1. Stiller K. Physiotherapy in intensive care: an updated systematic review. Chest. 2013;144(3):825–847.
    1. Bemis-Dougherty AR, Smith JM. What follows survival of critical illness? Physical therapists' management of patients with post-intensive care syndrome. Phys Ther. 2013;93(2):179–185.
    1. Davidson JE, Harvey MA, Bemis-Dougherty A, Smith JM, Hopkins RO. Implementation of the Pain, Agitation, and Delirium Clinical Practice Guidelines and promoting patient mobility to prevent post-intensive care syndrome. Crit Care Med. 2013;41(9) Suppl 1:S136–S145.
    1. Dantas CM, Silva PF, Siqueira FH, Pinto RM, Matias S, Maciel C, et al. Influence of early mobilization on respiratory and peripheral muscle strength in critically ill patients. Rev Bras Ter Intensiva. 2012;24(2):173–178.
    1. Tipping CJ, Harrold M, Holland A, Romero L, Nisbet T, Hodgson CL. The effects of active mobilisation and rehabilitation in ICU on mortality and function: a systematic review. Intensive Care Med. 2017;43(2):171–183.
    1. Abdulsatar F, Walker RG, Timmons BW, Choong K. "Wii-Hab" in critically ill children: a pilot trial. J Pediatr Rehabil Med. 2013;6(4):193–204.
    1. Choong K, Chacon MD, Walker RG, Al-Harbi S, Clark H, Al-Mahr G, et al. In-bed mobilization in critically ill children: a safety and feasibility trial. J Pediatr Intensive Care. 2015;4(4):225–234.
    1. Wieczorek B, Burke C, Al-Harbi A, Kudchadkar SR. Early mobilization in the pediatric intensive care unit: a systematic review. J Pediatr Intensive Care. 2015;4(4):212–217.
    1. Wieczorek B, Ascenzi J, Kim Y, Lenker H, Potter C, Shata NJ, et al. PICU Up!: Impact of a quality improvement intervention to promote early mobilization in critically ill children. Pediatr Crit Care Med. 2016;17(12):e559–e566.
    1. Choong K, Awladthani S, Khawaji A, Clark H, Borhan A, Cheng J, Laskey S, Neu C, Sarti A, Thabane L, Timmons BW, Zheng K, Al-Harbi S, Canadian Critical Care Trials Group Early exercise in critically ill youth and children, a preliminary evaluation: The wEECYCLE Pilot Trial. Pediatr Crit Care Med. 2017;18(11):e546–e554.
    1. Saliski M, Kudchadkar SR. Optimizing sedation management to promote early mobilization for critically ill children. J Pediatr Intensive Care. 2015;4(4):188–193.
    1. Hopkins RO, Choong K, Zebuhr CA, Kudchadkar SR. Transforming PICU culture to facilitate early rehabilitation. J Pediatr Intensive Care. 2015;4(4):204–211.
    1. Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA, PRISMA-P Group Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 2015;4:1–1.
    1. Wells GA, Shea B, O'Connell D, Peterson D, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014. [internet] Available from: .
    1. Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions. New Jersey: Wiley Online Library; 2008.
    1. Slim K, Nini E, Forestier D, Kwiatkowski F, Panis Y, Chipponi J. Methodological index for non-randomized studies (minors): development and validation of a new instrument. ANZ J Surg. 2003;73(9):712–716.
    1. Tsuboi N, Nozaki H, Ishida Y, Kanazawa I, Inamoto M, Hayashi K, et al. Early mobilization after pediatric liver transplantation. J Pediatr Intensive Care. 2017;6(3):199–205.
    1. Betters KA, Hebbar KB, Farthing D, Griego B, Easley T, Turman H, et al. Development and implementation of an early mobility program for mechanically ventilated pediatric patients. J Crit Care. 2017;41:303–308.
    1. Choong K, Foster G, Fraser DD, Hutchison JS, Joffe AR, Jouvet PA, Menon K, Pullenayegum E, Ward RE, Canadian Critical Care Trials Group Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med. 2014;15(6):e270–e279.
    1. Dubb R, Nydahl P, Hermes C, Schwabbauer N, Toonstra A, Parker AM, et al. Barriers and strategies for early mobilization of patients in intensive care units. Ann Am Thorac Soc. 2016;13(5):724–730.
    1. Choong K, Canci F, Clark H, Hopkins RO, Kudchadkar SR, Lati J, et al. Practice recommendations for early mobilization in critically ill children. J Pediatr Intensive Care. 2017;7(1):14–26.
    1. Biddiss E, Irwin J. Active video games to promote physical activity in children and youth: a systematic review. Arch Pediatr Adolesc Med. 2010;164(7):664–672.
    1. Bailey P, Thomsen GE, Spuhler VJ, Blair R, Jewkes J, Bezdjian L, et al. Early activity is feasible and safe in respiratory failure patients. Crit Care Med. 2007;35(1):139–145.
    1. Puthucheary ZA, Rawal J, McPhail M, Connolly B, Ratnayake G, Chan P, et al. Acute skeletal muscle wasting in critical illness. JAMA. 2013;310(15):1591–1600.
    1. Valla FV, Young DK, Rabilloud M, Periasami U, John M, Baudin F, et al. Thigh ultrasound monitoring identifies decreases in quadriceps femoris thickness as a frequent observation in critically ill children. Pediatr Crit Care Med. 2017;18(8):e339–e347.
    1. Simone S, Edwards S, Lardieri A, Walker LK, Graciano AL, Kishk OA, et al. Implementation of an ICU bundle: an interprofessional quality improvement project to enhance delirium management and monitor delirium prevalence in a single PICU. Pediatr Crit Care Med. 2017;18(6):531–540.
    1. Green M, Marzano V, Leditschke IA, Mitchell I, Bissett B. Mobilization of intensive care patients: a multidisciplinary practical guide for clinicians. J Multidiscip Healthc. 2016;9:247–256.
    1. Marra A, Ely EW, Pandharipande PP, Patel MB. The ABCDEF Bundle in Critical Care. Crit Care Clin. 2017;33(2):225–243.
    1. Cameron S, Ball I, Cepinskas G, Choong K, Doherty TJ, Ellis CG, et al. Early mobilization in the critical care unit: A review of adult and pediatric literature. J Crit Care. 2015;30(4):664–672.
    1. Fonseca JG, Ferreira AR. Application of the Pediatric Index of Mortality 2 in pediatric patients with complex chronic conditions. J Pediatr (Rio J) 2014;90(5):506–511. Portuguese.

Source: PubMed

3
Subscribe