Flavonoids, Inflammation and Immune System

Francisco J Pérez-Cano, Margarida Castell, Francisco J Pérez-Cano, Margarida Castell

Abstract

Flavonoids, including around 6000 phenolic compounds, are products of the secondary metabolism of plants which can be a part of one's diet via the consumption of many edible plants.[...].

Keywords: antioxidant; atherosclerosis; autoimmunity; cardiovascular disease; cytokine; immune response; inflammatory response; intestinal inflammation; lymphocyte functionality; macrophage activity.

Conflict of interest statement

The authors declare no conflict of interest.

References

    1. Kühnau J. The flavonoids. A class of semi-essential food components: Their role in human nutrition. World Rev. Nutr. Diet. 1976;24:117–191.
    1. Fantini M., Benvenuto M., Masuelli L., Frajese G.V., Tresoldi I., Modesti A., Bei R. In vitro and in vivo antitumoral effects of combinations of polyphenols, or polyphenols and anticancer drugs: Perspectives on cancer treatment. Int. J. Mol. Sci. 2015;16:9236–9282. doi: 10.3390/ijms16059236.
    1. Farzaei M.H., Bahramsoltani R., Rahimi R. Phytochemicals as adjunctive with conventional anticancer therapies. Curr. Pharm. Des. 2016;22:4201–4218. doi: 10.2174/1381612822666160601100823.
    1. El Haouari M., Rosado J.A. Medicinal plants with antiplatelet activity. Phyther. Res. 2016;30:1059–1071. doi: 10.1002/ptr.5619.
    1. Sirtori C.R., Arnoldi A., Cicero A.F.G. Nutraceuticals for blood pressure control. Ann. Med. 2015;47:447–456. doi: 10.3109/07853890.2015.1078905.
    1. Grassi D., Desideri G., Mai F., Martella L., De Feo M., Soddu D., Fellini E., Veneri M., Stamerra C.A., Ferri C. Cocoa, glucose tolerance, and insulin signaling: Cardiometabolic protection. J. Agric. Food Chem. 2015;63:9919–9926. doi: 10.1021/acs.jafc.5b00913.
    1. Jain P. Secondary metabolites for antiulcer activity. Nat. Prod. Res. 2015;30:640–656. doi: 10.1080/14786419.2015.1036269.
    1. Guan L.P., Liu B.Y. Antidepressant-like effects and mechanisms of flavonoids and related analogues. Eur. J. Med. Chem. 2016;121:47–57. doi: 10.1016/j.ejmech.2016.05.026.
    1. Sucher N.J., Carles M.C. A pharmacological basis of herbal medicines for epilepsy. Epilepsy Behav. 2015;52:308–318. doi: 10.1016/j.yebeh.2015.05.012.
    1. Diniz T.C., Silva J.C., de Lima-Saraiva S.R., Ribeiro F.P., Pacheco A.G., de Freitas R.M., Quintans-Júnior L.J., de Quintans J.S., Mendes R.L., Almeida J.R. The role of flavonoids on oxidative stress in epilepsy. Oxid. Med. Cell. Longev. 2015;2015:171756. doi: 10.1155/2015/171756.
    1. Spinello A., Bonsignore R., Barone G., Keppler B.K., Terenzi A. Metal ions and metal complexes in Alzheimer’s disease. Curr. Pharm. Des. 2016;22:3996–4010. doi: 10.2174/1381612822666160520115248.
    1. Bell L., Lamport D.J., Butler L.T., Williams C.M. A Review of the cognitive effects observed in humans following acute supplementation with flavonoids, and their associated mechanisms of action. Nutrients. 2015;7:10290–10306. doi: 10.3390/nu7125538.
    1. Vezza T., Rodríguez-Nogales A., Algieri F., Utrilla M.P., Rodriguez-Cabezas M.E., Galvez J. Flavonoids in inflammatory bowel disease: A review. Nutrients. 2016;8:659. doi: 10.3390/nu8040211.
    1. Goya L., Martín M.Á., Sarriá B., Ramos S., Mateos R., Bravo L. Effect of cocoa and its flavonoids on biomarkers of inflammation: Studies of cell culture, animals and humans. Nutrients. 2016;8:659. doi: 10.3390/nu8040212.
    1. Ellinger S., Stehle P. Impact of cocoa consumption on inflammation processes—A critical review of randomized controlled trials. Nutrients. 2016;8:659. doi: 10.3390/nu8060321.
    1. Yu J., Bi X., Yu B., Chen D. Isoflavones: Anti-inflammatory benefit and possible caveats. Nutrients. 2016;8:659. doi: 10.3390/nu8060361.
    1. Li Y., Yao J., Han C., Yang J., Chaudhry M.T., Wang S., Liu H., Yin Y. Quercetin, inflammation and immunity. Nutrients. 2016;8:659. doi: 10.3390/nu8030167.
    1. Semwal D.K., Semwal R.B., Combrinck S., Viljoen A. Myricetin: A dietary molecule with diverse biological activities. Nutrients. 2016;8:659. doi: 10.3390/nu8020090.
    1. Valderas-Martinez P., Chiva-Blanch G., Casas R., Arranz S., Martínez-Huélamo M., Urpi-Sarda M., Torrado X., Corella D., Lamuela-Raventós R.M., Estruch R. Tomato sauce enriched with olive oil exerts greater effects on cardiovascular disease risk factors than raw tomato and tomato sauce: A randomized trial. Nutrients. 2016;8:659. doi: 10.3390/nu8030170.
    1. Martín-Peláez S., Castañer O., Solà R., Motilva M.J., Castell M., Pérez-Cano F.J., Fitó M. Influence of phenol-enriched olive oils on human intestinal immune function. Nutrients. 2016;8:659. doi: 10.3390/nu8040213.
    1. Petrilli A.A., Souza S.J., Teixeira A.M., Pontilho P.M., Souza J.M.P., Luzia L.A., Rondó P.H.C. Effect of chocolate and yerba mate phenolic compounds on inflammatory and oxidative biomarkers in HIV/AIDS individuals. Nutrients. 2016;8:659. doi: 10.3390/nu8050132.
    1. Camps-Bossacoma M., Abril-Gil M., Saldaña-Ruíz S., Franch À., Pérez-Cano F.J., Castell M. Cocoa diet prevents antibody synthesis and modifies lymph node composition and functionality in a rat oral sensitization model. Nutrients. 2016;8:659. doi: 10.3390/nu8040242.
    1. Kim O.K., Jun W., Lee J. Effect of Cudrania tricuspidata and kaempferol in endoplasmic reticulum stress-induced inflammation and hepatic insulin resistance in HepG2 cells. Nutrients. 2016;8:659. doi: 10.3390/nu8010060.
    1. Tzeng T.F., Hong T.Y., Tzeng Y.C., Liou S.S., Liu I.M. Consumption of polyphenol-rich Zingiber Zerumbet rhizome extracts protects against the breakdown of the blood-retinal barrier and retinal inflammation induced by diabetes. Nutrients. 2015;7:7821–7841. doi: 10.3390/nu7095369.
    1. Sonoki H., Sato T., Endo S., Matsunaga T., Yamaguchi M., Yamazaki Y., Sugatani J., Ikari A. Quercetin decreases claudin-2 expression mediated by up-regulation of microRNA miR-16 in lung adenocarcinoma A549 cells. Nutrients. 2015;7:4578–4592. doi: 10.3390/nu7064578.
    1. Shin S.K., Cho S.J., Jung U.J., Ryu R., Choi M.S. Phlorizin supplementation attenuates obesity, inflammation, and hyperglycemia in diet-induced obese mice fed a high-fat diet. Nutrients. 2016;8:659. doi: 10.3390/nu8020092.

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