Local bio-absorbable antibiotic delivery in calcium sulfate beads in hip and knee arthroplasty

Abstract

Antibiotic-impregnated calcium sulfate (AICS) beads have been used for prevention and treatment of periprosthetic joint infections. We evaluated post-operative complications following the use of AICS beads. 56 patients undergoing complex primary or revision hip or knee arthroplasty received antibiotic calcium sulfate beads. Primary outcomes were wound complication rates. Secondary outcomes included reoperation and reinfection rates. One case (1.7%) of persistent wound drainage occurred requiring surgical irrigation and a poly-exchange. No post-operative infections were seen. Use of 100% pure calcium sulfate AICS beads may help reduce post-operative wound complications. AICS appears to be a safe adjunct tool in local antibiotic delivery.

Keywords: Antibiotic impregnated calcium sulfate beads; Osteoset; Periprosthetic joint infection; Revision total hip arthroplasty; Revision total knee arthroplasty; Stimulan.