Efficacy and safety of pre-gastroscopy commercial carbohydrate-rich whey protein beverage vs. plain water: a randomised controlled trial

Bee Chen Lua, Mohd Nizam Md Hashim, Mung Seong Wong, Yeong Yeh Lee, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Wan Zainira Wan Zain, Syed Hassan Syed Abd Aziz, Maya Mazuwin Yahya, Michael Pak-Kai Wong, Bee Chen Lua, Mohd Nizam Md Hashim, Mung Seong Wong, Yeong Yeh Lee, Andee Dzulkarnaen Zakaria, Zaidi Zakaria, Wan Zainira Wan Zain, Syed Hassan Syed Abd Aziz, Maya Mazuwin Yahya, Michael Pak-Kai Wong

Abstract

Clinical benefits and safety of carbohydrate loading pre-gastroscopy remain unclear. We aimed to determine the effects of a commercial carbohydrate-rich whey protein beverage versus plain water given pre-gastroscopy on gastric residual volume and well-being, and to determine adverse events. This was a single centre, single-blinded, parallel-group, sex-stratified randomized controlled trial. Participants were randomized either to carbohydrate-rich whey protein beverage group (Resource®, Nestle Health Science) or control group (250 ml plain water) given pre-gastroscopy. Gastric contents were aspirated into a suction reservoir bottle to determine the gastric residual volume (GRV). Visual analogue scale (VAS) of well-being (anxiety, hunger, thirst, tiredness, and weakness) was compared before and after the intervention. Adverse events were also evaluated post-intervention. Of 369 screened, 78 participants (36 males, mean age 49 ± 14.3 years) were randomized. Compared with the control group, carbohydrate beverage was associated with significantly higher GRV (p < 0.001). Anxiety was less after intervention with carbohydrate beverage (p = 0.016), and after adjustment for confounders, fewer participants also experienced hunger (p = 0.043) and thirst (p = 0.021). No serious adverse events were reported with both interventions. Commercial carbohydrate-rich whey protein beverage is associated with higher gastric residual volume, better well-being and safe.Trial registration Clinicaltrial.gov. Identifier: NCT03948594, Date of registration: 14/05/2019.

Conflict of interest statement

The authors declare no competing interests.

© 2022. The Author(s).

Figures

Figure 1
Figure 1
The suction reservoir bottle for GRV measurement.
Figure 2
Figure 2
CONSORT flow of the study.
Figure 3
Figure 3
Comparison of gastric residual volume.

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