SARS-CoV-2 and the testis: similarity with other viruses and routes of infection

Walter D Cardona Maya, Stefan S Du Plessis, Paula A Velilla, Walter D Cardona Maya, Stefan S Du Plessis, Paula A Velilla

Abstract

Since the start of the latest coronavirus (SARS-CoV-2) outbreak, the number of infected individuals and cases of coronavirus disease (COVID-19) has been increasing exponentially worldwide. Of interest is existing evidence that orchitis can develop due coronavirus infection. It is therefore not unreasonable to believe that SARS-CoV-2 could be transmitted by semen. Consequently, it is of paramount importance that individuals who could potentially be infected take all possible care to mitigate the likely risk of passing on the infection through sexual intercourse.

Keywords: COVID-19; Fertility; SARS-CoV-2; Sperm; Virus.

Copyright © 2020 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.

References

    1. Center for Diseases Control and Prevention (CDC), 2020. Clinical questions about COVID-19.
    1. Society for Assisted Reproductive Tecnology (SART), 2020. SART and ASRM issue advice for infertility patients concerning the novel coronavirus (COVID-19)..
    1. Cardona Maya W.D., Du Plessis S.S., Velilla P.A. Semen as virus reservoir? JARG. 2016;33:1255–1256.
    1. Cardona-Maya W.D., Velilla Hernandez P.A., Henao D.E. Male ebola survivors: Do not forget to use a condom! Reprod. Sci. 2019;26:1326. -1326.
    1. Ding Y., He L., Zhang Q., Huang Z., Che X., Hou J., Wang H., Shen H., Qiu L., Li Z., Geng J., Cai J., Han H., Li X., Kang W., Weng D., Liang P., Jiang S. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J. Pathol. 2004;203:622–630.
    1. Fan C., Li K., Ding Y., Lu L.W., Wang J. ACE2 expression in kidney and testis may cause kidney and testis damage after 2019-nCoV infection. medRxiv. 2020 doi: 10.1101/2020.02.12.20022418.
    1. Feldmann H. Virus in semen and the risk of sexual transmission. N. Engl. J. Med. 2018;378:1440–1441.
    1. Gu J., Gong E., Zhang B., Zheng J., Gao Z., Zhong Y., Zou W., Zhan J., Wang S., Xie Z., Zhuang H., Wu B., Zhong H., Shao H., Fang W., Gao D., Pei F., Li X., He Z., Xu D., Shi X., Anderson V.M., Leong A.S. Multiple organ infection and the pathogenesis of SARS. J. Exp. Med. 2005;202:415–424.
    1. La Marca A., Niederberger C., Pellicer A., Nelson S.M. COVID-19: lessons from the Italian reproductive medical experience. Fertil. Steril. 2020 doi: 10.1016/j.fertnstert.2020.03.021.
    1. Rothe C., Schunk M., Sothmann P., Bretzel G., Froeschl G., Wallrauch C., Zimmer T., Thiel V., Janke C. Transmission of 2019-nCoV infection from an asymptomatic contact in Germany. N. Engl. J. Med. 2020;382:970–971.
    1. Sigurðardóttir Ó., Kolbjørnsen O., Lutz H. Orchitis in a cat associated with coronavirus infection. J. Comp. Pathol. 2001;124:219–222.
    1. Xu J., Qi Lihua, Chi Xiaochun, Yang Jingjing, Wei Xiaohong, Gong Encong, Peh Suatcheng, Gu Jiang. Orchitis: A complication of severe acute respiratory syndrome (SARS) Biol. Reprod. 2006;74:410–416.
    1. Zhao J.M., Zhou G.D., Sun Y.L., Wang S.S., Yang J.F., Meng E.H., Pan D., Li W.S., Zhou X.S., Wang Y.D., Lu J.Y., Li N., Wang D.W., Zhou B.C., Zhang T.H. [Clinical pathology and pathogenesis of severe acute respiratory syndrome] Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi [Chin. J. Exp. and Clin. Vir.] 2003;17:217–221.

Source: PubMed

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