Cancers in Vietnam-Burden and Control Efforts: A Narrative Scoping Review

Tung Pham, Linh Bui, Giang Kim, Dong Hoang, Thuan Tran, Minh Hoang, Tung Pham, Linh Bui, Giang Kim, Dong Hoang, Thuan Tran, Minh Hoang

Abstract

Although the burden of cancer is rapidly growing in Vietnam, there was no up-to-date review that describes cancer burden and control in Vietnam throughout the literature. By identifying various risk factors, means of prevention, and methods for early detection, this review seeks to systematically summarize the evidence for the future planning and management of cancer occurrence in Vietnam. Additionally, this report aims to identify improvements which are necessary for the treatment and palliative care of patients with cancer in Vietnam. We employed a hybrid approach including both a scoping review and narrative synthesis for this study. Information was identified, extracted, and charted from various sources, which include international and domestically published studies, in addition to gray literature. Our results illustrate that the burden of cancer in Vietnam has tripled in the past 30 years, and this situation could be partly explained by the growing prevalence of both old and new risk factors. Besides hepatitis B virus, various other important risk factors such as human papilloma virus, tobacco usage, physical inactivity, and improper diets are still not under control in Vietnam. There is presently a lack of national cancer screening programs, and the capacity of cancer care services could not maintain pace with the demands of a rapidly increasing Vietnamese population. Overall, policy frameworks for cancer control in Vietnam are in place, but there is still a lack of proper financing and governing models necessary to support a sustainable program. In conclusion, Cancer and its associated consequences are both persistent and emerging problems in Vietnam, and the results of cancer control programs are limited. A comprehensive and evidence-based approach toward the prevention and treatment of cancer should be the future direction for Vietnam.

Keywords: NCDs; Vietnam; cancer; cancer burden; cancer control; early detection; health policy; health systems; prevention; review; screening; treatment.

Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
PRISMA flowchart showing the selection process of articles.
Figure 2.
Figure 2.
Trend of leading cancer incidence in Vietnam, 2000 to 2018.

References

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA a Cancer J Clin. 2018;68(6):394–424. doi:10.3322/caac.21492.
    1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA a Cancer J Clin. 2015;65(2):87–108. doi:10.3322/caac.21262.
    1. Farmer P, Frenk J, Knaul FM, et al. Expansion of cancer care and control in countries of low and middle income: a call to action. Lancet. 2010;376(9747):1186–1193. doi:10.1016/S0140-6736(10)61152-X.
    1. Prager GW, Braga S, Bystricky B, et al. Global cancer control: responding to the growing burden, rising costs and inequalities in access. ESMO Open. 2018;3(2):e000285 doi:10.1136/esmoopen-2017-000285.
    1. International Agency for Research on Cancer (IARC). Global Cancer Observatory—Vietnam Population fact sheets. . Accessed October 26, 2018.
    1. Anh PTH, Duc NB. The situation with cancer control in Vietnam. Jpn J Clin Oncol. 2002;32(suppl):S92–S97.
    1. Van Thuan T, Tuan Anh P, Van Tu D, Thi Thanh Huong T. Cancer control in Vietnam: where are we? | Cancer control. Cancel Control. 2016. . Accessed June 10, 2018.
    1. Van Thuan T, Dieu B, Thi Hoai Nga N. The status and future of cancer control in Vietnam. Vietnam Med J. 2018;472(suppl):1–8.
    1. World Health Organization. Vietnam—Overview: National Strategy for Cancer Control (2010 and 2020). 2006. . Accessed July 19, 2018.
    1. Mo H. National Strategy for the Prevention and Control of Noncommunicable Diseases 2015-2025. Hanoi, Vietnam; 2015:117 . Accessed October 28, 2018.
    1. Khalil H, Peters M, Godfrey CM, McInerney P, Soares CB, Parker D. An evidence-based approach to scoping reviews. Worldviews Evid Based Nurs. 2016;13(2):118–123. doi:10.1111/wvn.12144.
    1. Peters MDJ, Godfrey CM, Khalil H, McInerney P, Parker D, Soares CB. Guidance for conducting systematic scoping reviews. Int J Evid Based Healthc. 2015;13(3):141–146. doi:10.1097/XEB.0000000000000050.
    1. Tricco AC, Lillie E, Zarin W, et al. PRISMA extension for scoping reviews (PRISMA-SCR): checklist and explanation. Ann Internal Medicine. 2018;169(7):467 doi:10.7326/M18-0850.
    1. Hooper A. Lib Guides: Systematic Review Resources: Systematic Review Overview. . Accessed April 17, 2019.
    1. Nguyen BD. Results of the national cancer program 2008–2010. Vietnam Oncol J. 2010;(1):21–26.
    1. Mery L, Torode J, Pearlman P. Global Initiative for Cancer Registry Development Partners Task Force Visit to Vietnam. GICR; 2017.
    1. Nguyen BD, Dieu B, Thuan TV, et al. The cancer incidence of Vietnam in 2010 with reported data of 6 areas from 2004–2008. Vietnam Oncol J. 2010(1):73–80.
    1. Are C, Meyer B, Stack A, et al. Global trends in the burden of liver cancer. J Surg Oncol. 2017;115(5):591–602. doi:10.1002/jso.24518.
    1. Vuong DA, Velasco-Garrido M, Lai TD, Busse R. Temporal trends of cancer incidence in Vietnam. Asian Pac J Cancer Prev. 1993-2007;11(3):739–745.
    1. Dong HV, Lee AH, Nga NH, Quang N, Chuyen VL, Binns CW. Epidemiology and prevention of prostate cancer in Vietnam. Asian Pac J Cancer Prev. 2014;15(22):9747–9751. doi:10.7314/APJCP.2014.15.22.9747.
    1. Nhung NTT, Long TK, Linh BN, Vos T, Anh ND, Huong NT. Viet Nam Burden of Disease and Injury Study. Hanoi, Vietnam: Medical Publishing House; 2011.
    1. Nhung NTT, Long TK, Linh BN, Vos T, Huong NT, Anh ND. Estimation of Vietnam national burden of disease 2008. Asia Pac J Public Health. 2014;26(5):527–535. doi:10.1177/1010539513510556.
    1. Quach DT, Nguyen OT. Clinical, endoscopic and pathological characteristics of early-onset colorectal cancer in Vietnamese. Asian Pac J Cancer Prev. 2012;13(5):1767–1770. doi:10.7314/APJCP.2012.13.5.1767.
    1. The ACTION Study Group. Policy and priorities for national cancer control planning in low- and middle-income countries: lessons from the Association of Southeast Asian Nations (ASEAN) costs in oncology prospective cohort study. Eur J Cancer. 2017;74:26–37. doi:10.1016/j.ejca.2016.12.014.
    1. Lan NH, Laohasiriwong W, Stewart JF. Survival probability and prognostic factors for breast cancer patients in Vietnam. Global Health Action. 2013;6(1):18860 doi:10.3402/gha.v6i0.18860.
    1. Vu Hoang PT, Ambroise J, Dang Chi VL, et al. Comparison of long-term outcome between white and Vietnamese children treated for acute lymphoblastic leukemia according to the Fralle 2000 Protocol. J Pediatr Hematol Oncol. 2014;36(7):534–540. doi:10.1097/MPH.0000000000000062.
    1. Van Minh H, My NTT, Jit M. Cervical cancer treatment costs and cost-effectiveness analysis of human papillomavirus vaccination in Vietnam: a PRIME modeling study. BMC Health Serv Res. 2017;17(1). doi:10.1186/s12913-017-2297-x.
    1. Hoang Lan N, Laohasiriwong W, Frederick Stewart J, Dinh Tung N, Coyte PC. Cost of treatment for breast cancer in central Vietnam. Glob Health Action. 2013;6(1):18872 doi:10.3402/gha.v6i0.18872.
    1. Hoang VM, Pham CP, Vu QM, et al. Household financial burden and poverty impacts of cancer treatment in Vietnam. BioMed Res Int. 2017;2017:1–8. doi:10.1155/2017/9350147.
    1. Nguyen TH, Binh TTT, Anh NQ. Quality of life of breast cancer patients measured by QLQ-C30 and related factors in Oncology hospitals in Vietnam. Vietnam J Prev Med. 2017;27(5):102.
    1. Yen NTK, Weiss B, Trung LT. Caseness rates and risk factors for depression among Vietnamese cancer patients. Asian J Psychiatr. 2016;23:95–98. doi:10.1016/j.ajp.2016.07.020.
    1. Nguyen TV, Janssen MJR, van Oijen MGH, et al. Genetic polymorphisms in GSTA1, GSTP1, GSTT1, and GSTM1 and gastric cancer risk in a Vietnamese population. Oncol Res. 2009;18(7):349–355. doi:10.3727/096504010X12626118080064.
    1. Quoc NB, Phuong NDN, Ngan TK, Linh NTM, Cuong PH, Chau NNB. Expression of plasma hsa-miR122 in HBV-related hepatocellular carcinoma (HCC) in Vietnamese patients. Microrna. 2018;7(2):92–99. doi:10.2174/2211536607666180427165114.
    1. Nguyen HH, Nguyen HTT, Vu NP, et al. Mutational screening of germline RB1 gene in Vietnamese patients with retinoblastoma reveals three novel mutations. Mol Vis. 2018;24:231–238.
    1. Nguyen VTT, Law MG, Dore GJ. An enormous hepatitis B virus-related liver disease burden projected in Vietnam by 2025: an enormous HBV-related liver disease burden projected by 2025. Liver Int. 2008;28(4):525–531. doi:10.1111/j.1478-3231.2007.01646.x.
    1. Nguyen VTT, McLaws ML, Dore GJ. Highly endemic hepatitis B infection in rural Vietnam. J Gastroenterol Hepatol. 2007;22(12):2093–2100. doi:10.1111/j.1440-1746.2007.05010.x.
    1. Vietnam Ministry of Health. National Action Plan on Prevention and Control of Cervical Cancer 2016–2025. Hanoi, Vietnam: Vietnam Ministry of Health; 2016. .
    1. Quek SC, Lim BK, Domingo E, et al. Human papillomavirus type distribution in invasive cervical cancer and high-grade cervical intraepithelial neoplasia across 5 countries in Asia. Int J Gynecol Cancer. 2013;23(1):148–156. doi:10.1097/IGC.0b013e31827670fd.
    1. Vu LT, Bui D, Le HT. Prevalence of cervical infection with HPV type 16 and 18 in Vietnam: implications for vaccine campaign. BMC Cancer. 2013;13:53 doi:10.1186/1471-2407-13-53.
    1. Vu LTH, Bui D. Prevalence of cervical human papilloma virus infection among married women in Vietnam, 2011. Asian Pac J Cancer Prev. 2012;13(1):37–40. doi:10.7314/APJCP.2012.13.1.037.
    1. Vu L, Le H, Luong O, Tran H, Nguyen N, Luu H. Prevalence of cervical human papillomavirus infection among married women in Hanoi, Vietnam, 2010. Asia Pac J Public Health. 2012;24(2):385–390. doi:10.1177/1010539510393727.
    1. Domingo EJ, Noviani R, Noor MRM, et al. Epidemiology and prevention of cervical cancer in Indonesia, Malaysia, the Philippines, Thailand and Vietnam. Vaccine. 2008;26:(suppl 12):M7M71–M79. doi:10.1016/j.vaccine.2008.05.039.
    1. Anh PTH, Hieu NT, Herrero R, et al. Human papillomavirus infection among women in South and North Vietnam: HPV in Women in Vietnam. Int J Cancer. 2003;104(2):213–220. doi:10.1002/ijc.10936.
    1. Vu LTH, Le HTT. Cervical human papilloma virus infection among the general female population in Vietnam: a situation analysis. Asian Pac J Cancer Prev. 2011;12(2):561–566.
    1. Van SN, Khac MN, Dimberg J, Matussek A, Henningsson AJ. Prevalence of cervical infection and genotype distribution of human papilloma virus among females in Da Nang, Vietnam. Anticancer Res. 2017;37(3):1243–1247. doi:10.21873/anticanres.11440.
    1. de Sanjose S, Mbisa G, Perez-Alvarez S, et al. Geographic variation in the prevalence of Kaposi sarcoma–associated herpesvirus and risk factors for transmission. J Infect Dis. 2009;199(10):1449–1456. doi:10.1086/598523.
    1. Shin HR, Oh JK, Masuyer E, et al. Epidemiology of cholangiocarcinoma: an update focusing on risk factors. Cancer Sci. 2010;101(3):579–585. doi:10.1111/j.1349-7006.2009.01458.x.
    1. IARC Working Group on the Evaluation of Carcinogenic Risk to. Opisthorchis viverrini and Clonorchis sinensis. International Agency for Research on Cancer; 2012. . Accessed November 2, 2018.
    1. Norman RE, Vos T, Barendregt JJ, et al. Mortality attributable to smoking in Vietnamese men in 2008. Prev Med. 2013;57(3):232–237. doi:10.1016/j.ypmed.2013.05.016.
    1. Ng N, Winkler V, Minh HV, Tesfaye F, Wall S, Becher H. Predicting lung cancer death in Africa and Asia: differences with WHO estimates. Cancer Causes Control. 2009;20(5):721–730. doi:10.1007/s10552-008-9285-8.
    1. Van Minh H, Giang KB, Ngoc NB, et al. Prevalence of tobacco smoking in Vietnam: findings from the Global Adult Tobacco Survey 2015. Int J Public Health. 2017;62(suppl 1):121–129. doi:10.1007/s00038-017-0955-8.
    1. Nguyen TT, Hoang MV. Non-communicable diseases, food and nutrition in Vietnam from 1975 to 2015: the burden and national response. Asia Pac J Clin Nutr. 2018;27(1):19–28. doi:10.6133/apjcn.032017.13.
    1. Nichols HB, Trentham-Dietz A, Love RR, et al. Differences in breast cancer risk factors by tumor marker subtypes among premenopausal Vietnamese and Chinese women. Cancer Epidemiol Biomark Prev. 2005;14(1):41–47.
    1. Trieu PDY, Mello-Thoms C, Peat JK, Do TD, Brennan PC. Risk factors of female breast cancer in Vietnam: a case–control study. Cancer Res Treat. 2017;49(4):990–1000. doi:10.4143/crt.2016.488.
    1. Van Hoang D, Pham N, Lee A, Tran D, Binns C. Dietary carotenoid intakes and prostate cancer risk: a case–control study from Vietnam. Nutrients. 2018;10(1):70 doi:10.3390/nu10010070.
    1. Ngoan LT, Thu NT, Lua NT, et al. Cooking temperature, heat-generated-carcinogens, and the risk of stomach and colorectal cancers. Asian Pac J Cancer Prev. 2009;10(1):83–86.
    1. Vietnam Ministry of Health. Vietnam National Survey on the Risk Factors of NCDs (STEPS) 2015 Report. Hanoi, Vietnam: Vietnam Ministry of Health; 2016. . Accessed November 1, 2018.
    1. Reichart PA, Nguyen XH. Betel quid chewing, oral cancer and other oral mucosal diseases in Vietnam: a review: betel quid chewing in Vietnam. J Oral Pathol Med. 2008;37(9):511–514. doi:10.1111/j.1600-0714.2008.00669.x.
    1. Dang TH, Thanh DT, Huong NT, et al. Investigation of the Potential Association Between Endocrine Disrupting Chemicals (EDCs) and Breast Cancer Risk in Viet Nam. Hanoi, Vietnam: Hanoi University of Public Health; 2017:111 .
    1. Cordier S, Le TB, Verger P, et al. Viral infections and chemical exposures as risk factors for hepatocellular carcinoma in Vietnam. Int J Cancer. 1993;55(2):196–201.
    1. Schecter A, Toniolo P, Dai LC, Thuy LT, Wolff MS. Blood levels of DDT and breast cancer risk among women living in the north of Vietnam. Arch Environ Contam Toxicol. 1997;33(4):453–456.
    1. Ha MC, Cordier DS, Bard D, et al. Agent orange and the risk of gestational trophoblastic disease in Vietnam. Arch Environ Health Int J. 1996;51(5):368–374. doi:10.1080/00039896.1996.9934424.
    1. Huynh MLD, Raab SS, Suba EJ. Association between war and cervical cancer among Vietnamese women. Int J Cancer. 2004;110(5):775–777. doi:10.1002/ijc.20164.
    1. Suba EJ, Raab SS. Lessons learned from successful Papanicolaou cytology cervical cancer prevention in the socialist republic of Vietnam. Boon M, ed. Diagn Cytopathol. 2012;40(4):355–366. doi:10.1002/dc.21655.
    1. Vietnam Ministry of Health. Vietnam Joint Annual Health Review 2014. Strengthening Prevention and Control of Non-Communicable Disease. Hanoi, Vietnam: Vietnam Ministry of Health; 2015:328 . Accessed November 1, 2018.
    1. Lai TTH, Thuy TTT. Cervical cancer screening rate and its related factors among work women at two companies in Gò Vấp district, Ho Chi Minh City. Ho Chi Minh City Medical Journal. 2016;20(suppl 5):51–56.
    1. Bui D, Thuan TV, Nga NTH, et al. The screening results for early detection of breast and cervical cancer in some cities and provinces from 2008 to 2010. Vietnam Oncol J. 2010;(1):152–155.
    1. Bui D. Results of the national cancer program 2011–2014. Vietnam Oncol J. 2014;(2):21–28.
    1. Paul P, Winkler JL, Bartolini RM, et al. Screen-and-treat approach to cervical cancer prevention using visual inspection with acetic acid and cryotherapy: experiences, perceptions, and beliefs from demonstration projects in Peru, Uganda, and Vietnam. Oncologist. 2013;18(12):1278–1284. doi:10.1634/theoncologist.2013-0253.
    1. Vu Le C, Dao OQ, Khac Tran LN. Mass screening of prostate cancer in Vietnam: current status and our opinions. Urol Oncol. 2010;28(6):673–676. doi:10.1016/j.urolonc.2009.12.008.
    1. Catherine H. Vietnam Noncommunicable Disease Prevention and Control Programme 2002–2010. Geneva, Switzerland: WHO Press; 2011:73 . Accessed November 1, 2018.
    1. Vietnam Ministry of Health. Vietnam Decisions and Guidelines for Cancer Diagnosis and Treatment (Decree 5250, 2549, and 4825/QĐ-BYT). Hanoi, Vietnam: Vietnam Ministry of Health; 2012.
    1. Dayton V, Nguyen CK, Van TT, et al. Evaluation of opportunities to improve hematopathology diagnosis for Vietnam pathologists. Am J Clin Pathol. 2017;148(6):529–537. doi:10.1093/ajcp/aqx108.
    1. QuintilesIMS Institute. Global Oncology Trends 2017. . Accessed November 1, 2018.
    1. Krakauer EL, Ngoc NTM, Green K, Van Kham L, Khue LN. Vietnam: integrating palliative care into HIV/AIDS and cancer care. J Pain Symptom Manage. 2007;33(5):578–583. doi:10.1016/j.jpainsymman.2007.02.004.
    1. Reyes-Gibby CC, Ba Duc N, Phi Yen N, et al. Status of cancer pain in Hanoi, Vietnam: a hospital-wide survey in a tertiary cancer treatment center. J Pain Symptom Manage. 2006;31(5):431–439. doi:10.1016/j.jpainsymman.2005.10.005.
    1. Long NH, Thanasilp S, Thato R. A causal model for fatigue in lung cancer patients receiving chemotherapy. Eur J Oncol Nurs. 2016;21:242–247. doi:10.1016/j.ejon.2015.10.010.
    1. Kim JJ, Kobus KE, Diaz M, O’Shea M, Van Minh H, Goldie SJ. Exploring the cost-effectiveness of HPV vaccination in Vietnam: insights for evidence-based cervical cancer prevention policy. Vaccine. 2008;26(32):4015–4024. doi:10.1016/j.vaccine.2008.05.038.
    1. Goldie SJ, Diaz M, Kim SY, Levin CE, Van Minh H, Kim JJ. Mathematical models of cervical cancer prevention in the Asia Pacific region. Vaccine. 2008;26: M17–M29. doi:10.1016/j.vaccine.2008.06.018.
    1. Vietnam Health Insurance Agency. Vietnam Health Insurance Agency Decree 62/2009/NĐ-CP: Detailed Regulations and Implementation Guidelines of Articles Related to the Vietnam Law on Health Insurance. Hanoi, Vietnam: Vietnam Health Insurance Agency; 2009.
    1. The Economist Intelligence Unit. Controlling Cancer: The State of National Cancer Control Plans in Asia. Perspectives from The Economist Intelligence Unit (EIU). 2015. . Accessed November 21, 2018.
    1. The George Institute for Global Health. Policy Roundtable on ASEAN Member States Readiness in Cancer Control – “Turning Action Results into Policy Actions.” Bali, Indonesia; 2015. . Accessed November 20, 2018.
    1. Kimman M, Norman R, Jan S, Kingston D, Woodward M. The burden of cancer in member countries of the association of Southeast Asian Nations (ASEAN). Asian Pac J Cancer Prev. 2012;13(2):411–420. doi:10.7314/APJCP.2012.13.2.411.
    1. World Health Organization. Hepatitis B 3rd Dose (HepB3) Immunization Coverage. World Health Organization; . Accessed November 23, 2018.
    1. World Health Organization. Tackling NCDs: “Best Buys” and Other Recommended Interventions for the Prevention and Control of Noncommunicable Diseases. World Health Organization; 2017. . Accessed November 9, 2018.
    1. de Martel C, Plummer M, Vignat J, Franceschi S. Worldwide burden of cancer attributable to HPV by site, country and HPV type. Int J Cancer. 2017;141(4):664–670. doi:10.1002/ijc.30716.
    1. Bruni L, Diaz M, Barrionuevo-Rosas L, et al. Global estimates of human papillomavirus vaccination coverage by region and income level: a pooled analysis. Lancet Glob Health. 2016;4(7):e453–e463. doi:10.1016/S2214-109X(16)30099-7.
    1. Buse K, Hawkes S. Health post-2015: evidence and power. Lancet. 2014;383(9918):678–679. doi:10.1016/S0140-6736(13)61945-5.
    1. Shiffman J. Knowledge, moral claims and the exercise of power in global health. Int J Health Policy Manage. 2014;3(6):297–299. doi:0.15171/ijhpm.2014.120.
    1. Moore MA. Cancer control programs in East Asia: evidence from the international literature. J Prev Med Public Health. 2014;47(4):183–200. doi:10.3961/jpmph.2014.47.4.183.
    1. Gravitt PE, Belinson JL, Salmeron J, Shah KV. Looking ahead: a case for HPV testing of self-sampled vaginal specimens as a cervical cancer screening strategy. Int J Cancer. 2011;129(3):517–527. doi:10.1002/ijc.25974.
    1. Somanathan A, Tandon A, Dao HL, Hurt KL, Fuenzalida-Puelma HL. Moving toward Universal Coverage of Social Health Insurance in Vietnam: Assessment and Options. Washington, D.C: The World Bank; 2014.
    1. Vietnam Health Insurance Agency. Resolution No. 18/2008/NQ-QH12. Hanoi, Vietnam: Vietnam National Assembly; 2008.
    1. Van Minh H, Lan Huong D, Bao Giang K, Byass P. Economic aspects of chronic diseases in Vietnam. Glob Health Action. 2009;2(1):1965 doi:10.3402/gha.v2i0.1965.
    1. Thailand Ministry of Health. National Cancer Control Programmes 2013–2017. Thailand: Thailand Ministry of Health; 2013. . Accessed November 23, 2018.

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