Treatment of drooling with sublingual atropine sulfate in children and adolescents with cerebral palsy
Bruno L Scofano Dias, Alexandre R Fernandes, Heber de S Maia Filho, Bruno L Scofano Dias, Alexandre R Fernandes, Heber de S Maia Filho
Abstract
Objective: To report the effect of sublingual atropine sulfate to treat drooling in children with cerebral palsy by comparing the results of the Drooling Impact Scale in a non-controlled open clinical trial.
Results: Twenty-five children were assessed. The difference in the mean scores of the pre- and post-treatment scales reached statistical significance. There was a low frequency of side effects compared to studies with other anticholinergics.
Conclusion: The use of sublingual atropine sulfate seems to be safe and there is a reduction in the Drooling Impact Scale score, which suggests efficacy in the treatment of drooling in children and adolescents with cerebral palsy. Our results should be replicated in randomized, placebo-controlled studies with larger numbers of participants.
Source: PubMed