Persistent increase of prevalence of metabolic syndrome among U.S. adults: NHANES III to NHANES 1999-2006

Arupendra Mozumdar, Gary Liguori, Arupendra Mozumdar, Gary Liguori

Abstract

Objective: To compare the prevalence in metabolic syndrome (MetSyn) between 1988-1994 and 1999-2006 among U.S. adults of different races or ethnicities.

Research design and methods: Analysis of data on 6,423 adult men and nonpregnant women aged ≥20 years from Third National Health and Nutrition Examination Survey (NHANES III) and 6,962 participants from the combined NHANES 1999-2006 were done. The revised National Cholesterol Education Program Adult Treatment Panel III definition was used to calculate MetSyn.

Results: Both the unadjusted prevalence (27.9 ± 1.1% to 34.1 ± 0.8%, P < 0.001) and age-adjusted prevalence (29.2 ± 1.0% to 34.2 ± 0.7%, P < 0.001) increased from NHANES III to NHANES 1999-2006, respectively. Although MetSyn prevalence was highest in Mexican Americans, significant increases in prevalence occurred among non-Hispanic whites and non-Hispanic blacks, especially among younger women.

Conclusions: The persistent increase of MetSyn among U.S. adults is a serious public health concern because it raises the likelihood of increased prevalence of type 2 diabetes.

References

    1. Meigs JB, Wilson PW, Fox CS, Vasan RS, Nathan DM, Sullivan LM, D'Agostino RB: Body mass index, metabolic syndrome, and risk of type 2 diabetes or cardiovascular disease. J Clin Endocrinol Metab 2006;91:2906–2912
    1. Galassi A, Reynolds K, He J: Metabolic syndrome and risk of cardiovascular disease: a meta-analysis. Am J Med 2006;119:812–819
    1. Malik S, Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR, Williams GR: Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004;110:1245–1250
    1. Ford ES, Giles WH, Dietz WH: Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002;287:356–359
    1. Aguilar-Salinas CA, Rojas R, Gómez-Pérez FJ, Valles V, Ríos-Torres JM, Franco A, Olaiz G, Rull JA, Sepulveda J: Analysis of the agreement between the World Health Organization criteria and the National Cholesterol Education Program-III definition of the metabolic syndrome: results from a population-based survey. Diabetes Care 2003;26:1635.
    1. Lim S, Jang HC, Lee HK, Kimm KC, Park C, Cho NH: A rural-urban comparison of the characteristics of the metabolic syndrome by gender in Korea: the Korean Health and Genome Study (KHGS). J Endocrinol Invest 2006;29:313–319
    1. Kozan O, Oguz A, Abaci A, Erol C, Ongen Z, Temizhan A, Celik S: Prevalence of the metabolic syndrome among Turkish adults. Eur J Clin Nutr 2007;61:548–553
    1. Churilla JR, Fitzhugh EC, Thompson DL: The metabolic syndrome: how definition impacts the prevalence and risk among U.S. adults, NHANES 1999–2004. Metab Syndr Relat Disord 2007;5:331–342
    1. Ford ES, Giles WH, Mokdad AH: Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care 2004;27:2444–2449
    1. Grundy SM, Brewer HB, Jr, Cleeman JI, Smith SC, Jr, Lenfant CAmerican Heart Association, National Heart, Lung, and Blood Institute Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 2004;109:433–438
    1. About the National Health and Nutrition Examination Survey [Internet]. Atlanta, Georgia, Centers for Disease Control and Prevention; Available from Accessed 22 April 2010
    1. Gunter EW, Lewis BG, Koncikowski SM: Laboratory procedures used for the third national health and nutrition examination survey (NHANES III), 1988–1994 [article online], 1996. Hyattsville, MD, Centers for Disease Control and Prevention; Available from Accessed 22 April 2010
    1. National Health and Nutrition Examination Survey: laboratory procedures manual [Internet], 2005. Hyattsville, MD, Centers for Disease Control and Prevention. Available at Accessed 22 April 2010
    1. When and how to construct weights when combining survey cycles [Internet]. Hyattsville, MD, National Center for Health Statistics; Available from Accessed 22 April 2010

Source: PubMed

3
Subscribe