Does traffic exhaust contribute to the development of asthma and allergic sensitization in children: findings from recent cohort studies

Lennart Bråbäck, Bertil Forsberg, Lennart Bråbäck, Bertil Forsberg

Abstract

The aim of this review was to assess the evidence from recent prospective studies that long-term traffic pollution could contribute to the development of asthma-like symptoms and allergic sensitization in children. We have reviewed cohort studies published since 2002 and found in PubMed in Oct 2008. In all, 13 papers based on data from 9 cohorts have evaluated the relationship between traffic exposure and respiratory health. All surveys reported associations with at least some of the studied respiratory symptoms. The outcome varied, however, according to the age of the child. Nevertheless, the consistency in the results indicates that traffic exhaust contributes to the development of respiratory symptoms in healthy children. Potential effects of traffic exhaust on the development of allergic sensitization were only assessed in the four European birth cohorts. Long-term exposure to outdoor air pollutants had no association with sensitization in ten-year-old schoolchildren in Norway. In contrast, German, Dutch and Swedish preschool children had an increased risk of sensitization related to traffic exhaust despite fairly similar levels of outdoor air pollution as in Norway. Traffic-related effects on sensitization could be restricted to individuals with a specific genetic polymorphism. Assessment of gene-environment interactions on sensitization has so far only been carried out in a subgroup of the Swedish birth cohort. Further genetic association studies are required and may identify individuals vulnerable to adverse effects from traffic-related pollutants. Future studies should also evaluate effects of traffic exhaust on the development and long term outcome of different phenotypes of asthma and wheezing symptoms.

References

    1. O'Connor GT, Neas L, Vaughn B, Kattan M, Mitchell H, Crain EF, Evans R 3rd, Gruchalla R, Morgan W, Stout J, Adams GK, Lippmann M. Acute respiratory health effects of air pollution on children with asthma in US inner cities. The Journal of allergy and clinical immunology. 2008;121:1133–1139. doi: 10.1016/j.jaci.2008.02.020. e1131.
    1. Andersen ZJ, Loft S, Ketzel M, Stage M, Scheike T, Hermansen MN, Bisgaard H. Ambient air pollution triggers wheezing symptoms in infants. Thorax. 2008;63:710–716. doi: 10.1136/thx.2007.085480.
    1. Gent JF, Triche EW, Holford TR, Belanger K, Bracken MB, Beckett WS, Leaderer BP. Association of low-level ozone and fine particles with respiratory symptoms in children with asthma. Jama. 2003;290:1859–1867. doi: 10.1001/jama.290.14.1859.
    1. Tolbert PE, Mulholland JA, MacIntosh DL, Xu F, Daniels D, Devine OJ, Carlin BP, Klein M, Dorley J, Butler AJ, Nordenberg DF, Frumkin H, Ryan PB, White MC. Air quality and pediatric emergency room visits for asthma in Atlanta, Georgia, USA. American journal of epidemiology. 2000;151:798–810.
    1. Atkinson RW, Anderson HR, Sunyer J, Ayres J, Baccini M, Vonk JM, Boumghar A, Forastiere F, Forsberg B, Touloumi G, Schwartz J, Katsouyanni K. Acute effects of particulate air pollution on respiratory admissions: results from APHEA 2 project. Air Pollution and Health: a European Approach. American journal of respiratory and critical care medicine. 2001;164:1860–1866.
    1. Kelly FJ. Oxidative stress: its role in air pollution and adverse health effects. Occupational and environmental medicine. 2003;60:612–616. doi: 10.1136/oem.60.8.612.
    1. Sackesen C, Ercan H, Dizdar E, Soyer O, Gumus P, Tosun BN, Buyuktuncer Z, Karabulut E, Besler T, Kalayci O. A comprehensive evaluation of the enzymatic and nonenzymatic antioxidant systems in childhood asthma. The Journal of allergy and clinical immunology. 2008;122:78–85. doi: 10.1016/j.jaci.2008.03.035.
    1. Diaz-Sanchez D, Proietti L, Polosa R. Diesel fumes and the rising prevalence of atopy: an urban legend? Current allergy and asthma reports. 2003;3:146–152. doi: 10.1007/s11882-003-0027-4.
    1. Ryan PH, LeMasters G, Biagini J, Bernstein D, Grinshpun SA, Shukla R, Wilson K, Villareal M, Burkle J, Lockey J. Is it traffic type, volume, or distance? Wheezing in infants living near truck and bus traffic. J Allergy Clin Immunol. 2005;116:279–284. doi: 10.1016/j.jaci.2005.05.014.
    1. Liu J, Ballaney M, Al-alem U, Quan C, Jin X, Perera F, Chen LC, Miller RL. Combined inhaled diesel exhaust particles and allergen exposure alter methylation of T helper genes and IgE production in vivo. Toxicol Sci. 2008;102:76–81. doi: 10.1093/toxsci/kfm290.
    1. Trasande L, Thurston GD. The role of air pollution in asthma and other pediatric morbidities. J Allergy Clin Immunol. 2005;115:689–699. doi: 10.1016/j.jaci.2005.01.056.
    1. Bateson TF, Schwartz J. Children's response to air pollutants. Journal of toxicology and environmental health. 2008;71:238–243. doi: 10.1080/15287390701598234.
    1. Dietert RR, Etzel RA, Chen D, Halonen M, Holladay SD, Jarabek AM, Landreth K, Peden DB, Pinkerton K, Smialowicz RJ, Zoetis T. Workshop to identify critical windows of exposure for children's health: immune and respiratory systems work group summary. Environmental health perspectives. 2000;108(Suppl 3):483–490. doi: 10.2307/3454540.
    1. Pinkerton KE, Joad JP. Influence of air pollution on respiratory health during perinatal development. Clin Exp Pharmacol Physiol. 2006;33:269–272. doi: 10.1111/j.1440-1681.2006.04357.x.
    1. Morgan WJ, Stern DA, Sherrill DL, Guerra S, Holberg CJ, Guilbert TW, Taussig LM, Wright AL, Martinez FD. Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence. Am J Respir Crit Care Med. 2005;172:1253–1258. doi: 10.1164/rccm.200504-525OC.
    1. Dean T, Venter C, Pereira B, Arshad SH, Grundy J, Clayton CB, Higgins B. Patterns of sensitization to food and aeroallergens in the first 3 years of life. The Journal of allergy and clinical immunology. 2007;120:1166–1171. doi: 10.1016/j.jaci.2007.06.042.
    1. Sandin A, Björkstén B, Bråbäck L. Development of atopy and wheezing symptoms in relation to heredity and early pet keeping in a Swedish birth cohort. Pediatr Allergy Immunol. 2004;15:316–322. doi: 10.1111/j.1399-3038.2004.00166.x.
    1. Sly PD, Boner AL, Björkstén B, Bush A, Custovic A, Eigenmann PA, Gern JE, Gerritsen J, Hamelmann E, Helms PJ, Lemanske RF, Martinez F, Pedersen S, Renz H, Sampson H, von Mutius E, Wahn U, Holt PG. Early identification of atopy in the prediction of persistent asthma in children. Lancet. 2008;372:1100–1106. doi: 10.1016/S0140-6736(08)61451-8.
    1. Kryzyzanowski M, Kuna-Dibbert B, Schneider J. Health effects of transport-related air pollution. Copenhagen: WHO Regional Office for Europe; 2005. p. 190.
    1. Krzyzanowski MK-DB, Schneider J. Health effects of transport-related air pollution. Office WR. Copenhagen: WHO; 2005. p. 205.
    1. Heinrich J, Gehring U, Cyrys J, Brauer M, Hoek G, Fischer P, Bellander T, Brunekreef B. Exposure to traffic related air pollutants: self reported traffic intensity versus GIS modelled exposure. Occupational and environmental medicine. 2005;62:517–523. doi: 10.1136/oem.2004.016766.
    1. Islam T, Gauderman WJ, Berhane K, McConnell R, Avol E, Peters JM, Gilliland FD. Relationship between air pollution, lung function and asthma in adolescents. Thorax. 2007;62:957–963. doi: 10.1136/thx.2007.078964.
    1. Shima M, Nitta Y, Adachi M. Traffic-related air pollution and respiratory symptoms in children living along trunk roads in Chiba Prefecture, Japan. J Epidemiol. 2003;13:108–119.
    1. Shima M, Nitta Y, Ando M, Adachi M. Effects of air pollution on the prevalence and incidence of asthma in children. Arch Environ Health. 2002;57:529–535.
    1. Jerrett M, Shankardass K, Berhane K, Gauderman WJ, Kunzli N, Avol E, Gilliland F, Lurmann F, Molitor JN, Molitor JT, Thomas DC, Peters J, McConnell R. Traffic-related air pollution and asthma onset in children: a prospective cohort study with individual exposure measurement. Environmental health perspectives. 2008;116:1433–1438.
    1. Morgenstern V, Zutavern A, Cyrys J, Brockow I, Gehring U, Koletzko S, Bauer CP, Reinhardt D, Wichmann HE, Heinrich J. Respiratory health and individual estimated exposure to traffic-related air pollutants in a cohort of young children. Occupational and environmental medicine. 2007;64:8–16. doi: 10.1136/oem.2006.028241.
    1. Morgenstern V, Zutavern A, Cyrys J, Brockow I, Koletzko S, Kramer U, Behrendt H, Herbarth O, von Berg A, Bauer CP, Wichmann HE, Heinrich J. GINI Study Group; LISA Study Group. Atopic diseases, allergic sensitization, and exposure to traffic-related air pollution in children. American journal of respiratory and critical care medicine. 2008;177:1331–1337. doi: 10.1164/rccm.200701-036OC.
    1. Melén E, Nyberg F, Lindgren CM, Berglind N, Zucchelli M, Nordling E, Hallberg J, Svartengren M, Morgenstern R, Kere J, Bellander T, Wickman M, Pershagen G. Interactions between glutathione S-transferase P1, tumor necrosis factor, and traffic-related air pollution for development of childhood allergic disease. Environ Health Perspect. 2008;116:1077–1084.
    1. Nordling E, Berglind N, Melen E, Emenius G, Hallberg J, Nyberg F, Pershagen G, Svartengren M, Wickman M, Bellander T. Traffic-related air pollution and childhood respiratory symptoms, function and allergies. Epidemiology (Cambridge, Mass) 2008;19:401–408.
    1. Oftedal B, Brunekreef B, Nystad W, Nafstad P. Residential outdoor air pollution and allergen sensitization in schoolchildren in Oslo, Norway. Clin Exp Allergy. 2007;37:1632–1640. doi: 10.1111/j.1365-2222.2007.02823.x.
    1. Brauer M, Hoek G, Van Vliet P, Meliefste K, Fischer PH, Wijga A, Koopman LP, Neijens HJ, Gerritsen J, Kerkhof M, Heinrich J, Bellander T, Brunekreef B. Air pollution from traffic and the development of respiratory infections and asthmatic and allergic symptoms in children. American journal of respiratory and critical care medicine. 2002;166:1092–1098. doi: 10.1164/rccm.200108-007OC.
    1. Clougherty JE, Levy JI, Kubzansky LD, Ryan PB, Suglia SF, Canner MJ, Wright RJ. Synergistic effects of traffic-related air pollution and exposure to violence on urban asthma etiology. Environmental health perspectives. 2007;115:1140–1146.
    1. Gehring U, Cyrys J, Sedlmeir G, Brunekreef B, Bellander T, Fischer P, Bauer CP, Reinhardt D, Wichmann HE, Heinrich J. Traffic-related air pollution and respiratory health during the first 2 yrs of life. Eur Respir J. 2002;19:690–698. doi: 10.1183/09031936.02.01182001.
    1. Ryan PH, Lemasters GK, Biswas P, Levin L, Hu S, Lindsey M, Bernstein DI, Lockey J, Villareal M, Khurana Hershey GK, Grinshpun SA. A comparison of proximity and land use regression traffic exposure models and wheezing in infants. Environ Health Perspect. 2007;115:278–284.
    1. Brauer M, Hoek G, Smit HA, de Jongste JC, Gerritsen J, Postma DS, Kerkhof M, Brunekreef B. Air pollution and development of asthma, allergy and infections in a birth cohort. Eur Respir J. 2007;29:879–888. doi: 10.1183/09031936.00083406.
    1. Piippo-Savolainen E, Korppi M. Wheezy babies – wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing. Acta Paediatr. 2008;97:5–11. doi: 10.1111/j.1651-2227.2007.00558.x.
    1. Henderson J, Granell R, Heron J, Sherriff A, Simpson A, Woodcock A, Strachan DP, Shaheen SO, Sterne JA. Associations of wheezing phenotypes in the first 6 years of life with atopy, lung function and airway responsiveness in mid-childhood. Thorax. 2008;63:974–980. doi: 10.1136/thx.2007.093187.
    1. McLeish S, Turner SW. Gene-environment interactions in asthma. Archives of disease in childhood. 2007;92:1032–1035. doi: 10.1136/adc.2006.112185.
    1. Yang IA, Fong KM, Zimmerman PV, Holgate ST, Holloway JW. Genetic susceptibility to the respiratory effects of air pollution. Thorax. 2008;63:555–563. doi: 10.1136/thx.2007.079426.
    1. Edwards TM, Myers JP. Environmental exposures and gene regulation in disease etiology. Environmental health perspectives. 2007;115:1264–1270.
    1. Ercan H, Birben E, Dizdar EA, Keskin O, Karaaslan C, Soyer OU, Dut R, Sackesen C, Besler T, Kalayci O. Oxidative stress and genetic and epidemiologic determinants of oxidant injury in childhood asthma. The Journal of allergy and clinical immunology. 2006;118:1097–1104. doi: 10.1016/j.jaci.2006.08.012.
    1. Lee JT, Son JY, Cho YS. Benefits of mitigated ambient air quality due to transportation control on childhood asthma hospitalization during the 2002 summer Asian games in Busan, Korea. J Air Waste Manag Assoc. 2007;57:968–973.
    1. Salam MT, Gauderman WJ, McConnell R, Lin PC, Gilliland FD. Transforming growth factor-1 C-509T polymorphism, oxidant stress, and early-onset childhood asthma. American journal of respiratory and critical care medicine. 2007;176:1192–1199. doi: 10.1164/rccm.200704-561OC.
    1. Motta AC, Marliere M, Peltre G, Sterenberg PA, Lacroix G. Traffic-related air pollutants induce the release of allergen-containing cytoplasmic granules from grass pollen. Int Arch Allergy Immunol. 2006;139:294–298. doi: 10.1159/000091600.
    1. Traidl-Hoffmann C, Kasche A, Menzel A, Jakob T, Thiel M, Ring J, Behrendt H. Impact of pollen on human health: more than allergen carriers? International archives of allergy and immunology. 2003;131:1–13. doi: 10.1159/000070428.
    1. Yoshino S, Hayashi H, Taneda S, Takano H, Sagai M, Mori Y. Effect of diesel exhaust particle extracts on induction of oral tolerance in mice. Toxicol Sci. 2002;66:293–297. doi: 10.1093/toxsci/66.2.293.
    1. Vercelli D, Martinez FD. The Faustian bargain of genetic association studies: bigger might not be better, or at least it might not be good enough. The Journal of allergy and clinical immunology. 2006;117:1303–1305. doi: 10.1016/j.jaci.2006.03.030.

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