The impact of fasting on the interpretation of triglyceride levels for predicting myocardial infarction risk in HIV-positive individuals: the D:A:D study
Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study, David A Kamara, Signe W Worm, Peter Reiss, Martin Rickenbach, Andrew Phillips, Ole Kirk, Antonella D'Arminio Monforte, Mathias Bruyand, Matthew Law, Stephane De Wit, Colette J Smith, Christian Pradier, Jens Lundgren, Caroline Sabin, Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) Study, David A Kamara, Signe W Worm, Peter Reiss, Martin Rickenbach, Andrew Phillips, Ole Kirk, Antonella D'Arminio Monforte, Mathias Bruyand, Matthew Law, Stephane De Wit, Colette J Smith, Christian Pradier, Jens Lundgren, Caroline Sabin
Abstract
We assessed whether fasting modifies the prognostic value of these measurements for the risk of myocardial infarction (MI). Analyses used mixed effect models and Poisson regression. After confounders were controlled for, fasting triglyceride levels were, on average, 0.122 mmol/L lower than nonfasting levels. Each 2-fold increase in the latest triglyceride level was associated with a 38% increase in MI risk (relative rate, 1.38; 95% confidence interval, 1.26-1.51); fasting status did not modify this association. Our results suggest that it may not be necessary to restrict analyses to fasting measurements when considering MI risk.
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Source: PubMed