The regulation of permeability barrier homeostasis
Kenneth R Feingold, Matthias Schmuth, Peter M Elias, Kenneth R Feingold, Matthias Schmuth, Peter M Elias
Abstract
Disruption of the permeability barrier stimulates a repair response that leads to the restoration of barrier function. Previous studies demonstrated that changes in ions, particularly calcium, and cytokines are positive signals, whereas serine protease activation of proteinase-activated receptor 2 is a negative signal regulating barrier recovery. Ikeyama and colleagues provide data that the nitric oxide signaling pathway also regulates barrier homeostasis.
Source: PubMed