Physical Activity Intervention in Patients with Metastatic Breast Cancer During Active Treatment: Quality of Life and Function

Shlomit Strulov Shachar, Hillary Heiling, Hyman B Muss, Damone Meghan, Chad W Wagoner, Allison M Deal, Kirsten A Nyrop, Shlomit Strulov Shachar, Hillary Heiling, Hyman B Muss, Damone Meghan, Chad W Wagoner, Allison M Deal, Kirsten A Nyrop

Abstract

Background: In this study, we explore recruitment, retention, and potential quality of life (QoL) and function benefits from a self-directed, home-based walking intervention in women during active treatment for metastatic breast cancer (MBC).

Methods: In this single-arm pilot study, women with stage IV BC wore an activity tracker (FitbitTM) to measure steps per week throughout the intervention study. Participants were asked to walk 150 min per week at a comfortable and safe pace. Patient-reported outcome measures (PRO) were collected at baseline and follow-up.

Results: Target recruitment of 60 patients was achieved. In 52 patients who completed all baseline measures, mean age was 55 (SD 11.1), 23% were pre-menopausal, and 19% non-White. Forty patients (77%) were retained at 3 months and 29 (56%) at 6 months. Baseline walking was the strongest predictor of retention at 3 months (P = .02). For 24 patients (46%) with analyzable Fitbit data at 3 months, mean steps/week rose from 19,175 to 31,306. Higher number of steps correlated with larger improvements FACT-G General well-being (FACT-G, rho = 0.55, P = .01), FACT-G Physical well-being (rho = 0.48, P = .03), and PROMIS Mental Health (rho = 0.55, P = .01).

Conclusion: Recruitment into a walking intervention is feasible (a priory target of N = 60) in women during treatment for MBC, but retention at 3 months follow-up fell short (77% versus a priori 80%), yet there were potential benefits in general and physical well-being and mental health.

Clinicaltrials.gov identifier: NCT02682836.

Keywords: breast cancer; quality of life.

© The Author(s) 2022. Published by Oxford University Press.

Figures

Figure 1.
Figure 1.
Activity tracker steps/week.
Figure 2.
Figure 2.
STROBE chart.
Figure 3.
Figure 3.
Correlations between median steps and score changes.

References

    1. Nyrop KA, Deal AM, Choi SK, et al. . Measuring and understanding adherence in a home-based exercise intervention during chemotherapy for early breast cancer. Breast Cancer Res Treat. 2018;168(1):43-55. 10.1007/s10549-017-4565-1.
    1. Arthritis Foundation. Walk with Ease: Your Guide to Walking for Better Health, Improved Fitness and Less Pain (Third Edition). Arthritis Foundation 2010.
    1. Rock CL, Doyle C, Demark-Wahnefried W, et al. . Nutrition and physical activity guidelines for cancer survivors. CA Cancer J Clin. 2012;62(4):243-274. 10.3322/caac.21142.
    1. Doyle C, Kushi LH, Byers T, Courneya KS, et al. . Nutrition and physical activity during and after cancer treatment: an American Cancer Society guide for informed choices. Cancer J Clin. 2006;56:323-353.
    1. Brady MJ, Cella DF, Mo F.. Bonomi AE, Tulsky DS, al. e. Reliability and validity of the Functional Assessment of Cancer Therapy-Breast (FACT-B) quality of life instrument. J Clin Oncol. 1997;15(3):974-986. 10.1200/JCO.1997.15.3.974
    1. Webster K, Cella D, Yost K.. The Functional Assessment of Chronic Illness Therapy (FACIT) measurement system: properties, applications, and interpretation. Health Quality Life Outcomes. 2003;1(1):79. 10.1186/1477-7525-1-79.
    1. Cella D, Riley W, Stone A, et al. ; PROMIS Cooperative Group. The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005–2008. J Clin Epidemiol. 2010;63(11):1179-1194. 10.1016/j.jclinepi.2010.04.011.
    1. Reeve BB, Burke LB, Chiang YP, et al. . Enhancing measurement in health outcomes research supported by Agencies within the US Department of Health and Human Services. Quality Life Res. 2007;16(Suppl 1):175-186. 10.1007/s11136-007-9190-8.
    1. Resnick B, Zimmerman S, Orwig D, Furstenberg AL, Magaziner J.. Model testing for reliability and validity of the outcome expectations for exercise scale. NursRes. 2001;50(5):293-299.
    1. Hoffman AJ, Von Eye A, Gift AG, et al. . The development and testing of an instrument for perceived self-efficacy for fatigue self-management. Cancer Nurs. 2011;34(3):167-175. 10.1097/NCC.0b013e31820f4ed1.
    1. Ligibel JA, Huebner L, Rugo HS, et al. . Physical activity, weight, and outcomes in patients receiving chemotherapy for metastatic breast cancer (C40502/Alliance). JNCI Cancer Spectr. 2021;5(3):pkab025. 10.1093/jncics/pkab025.
    1. Dragomir BI, Fodoreanu L.. Correlations between state anxiety and quality of life in metastatic breast cancer patients. Rev Med Chir Soc Med Nat Iasi. 2013;117(3):610-615.

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