Myocardial collagen metabolism in failing hearts before and during cardiac resynchronization therapy
Soban Umar, Jeroen J Bax, Margreet Klok, Rutger J van Bommel, Marleen H M Hessel, Brigit den Adel, Gabe B Bleeker, Maureen M Henneman, Douwe E Atsma, Ernst E van der Wall, Martin J Schalij, Arnoud van der Laarse, Soban Umar, Jeroen J Bax, Margreet Klok, Rutger J van Bommel, Marleen H M Hessel, Brigit den Adel, Gabe B Bleeker, Maureen M Henneman, Douwe E Atsma, Ernst E van der Wall, Martin J Schalij, Arnoud van der Laarse
Abstract
Background: In patients with heart failure cardiac resynchronization therapy (CRT) leads to reverse ventricular remodelling.
Aim: To evaluate whether myocardial collagen metabolism in patients with heart failure is implicated in adverse ventricular remodelling and response to CRT.
Methods: Collagen synthesis and degradation were assessed from the concentrations of aminoterminal propeptides of type I and type III collagen (PINP and PIIINP) and carboxyterminal telopeptide of type I collagen (ICTP), respectively, in serum of 64 patients with heart failure before and after 6 months of CRT. Forty-six patients (72%) showed a > 10% reduction in LV end-systolic volume at follow-up and were classified as responders to CRT, the other 18 patients (28%) were classified as non-responders.
Results: Responders demonstrated a mean (+/-SEM) increase of serum PINP and PIIINP during follow-up, from 32.9+/-2.2 to 46.7+/-4.0 microg/L (p < 0.001) and from 4.59+/-0.24 to 5.13+/-0.36 microg/L (p < 0.05), respectively. In non-responders, serum PINP and PIIINP remained unchanged during follow-up. At baseline, responders had significantly lower serum PINP than non-responders (32.9+/-2.2 vs. 41.8+/-4.3 microg/L; p < 0.05). ICTP levels of responders at baseline tended to be higher than in non-responders (3.54+/-0.56 vs. 2.08+/-0.37 microg/L, p = ns), and in both groups ICTP levels did not change upon CRT.
Conclusion: Reverse LV remodelling following CRT is associated with increased collagen synthesis rate in the first 6 months of follow-up.
Source: PubMed