Using attentional bias modification as a cognitive vaccine against depression

Michael Browning, Emily A Holmes, Matthew Charles, Philip J Cowen, Catherine J Harmer, Michael Browning, Emily A Holmes, Matthew Charles, Philip J Cowen, Catherine J Harmer

Abstract

Background: Negative attentional biases are thought to increase the risk of recurrence in depression, suggesting that reduction of such biases may be a plausible strategy in the secondary prevention of the illness. However, no previous study has tested whether reducing negative attentional bias causally affects risk factors for depressive recurrence. The current experimental medicine study reports the effects of a computerized attentional bias modification (ABM) procedure on intermediate measures of the risk of depressive recurrence (residual depressive symptoms and the cortisol awakening response) in patients with recurrent depression.

Methods: Sixty-one patients with at least two previous episodes of depression who were currently in remission were randomized to receive either an active (positive) or placebo computer-based ABM regime. The ABM regime presented either pictures of faces or words. Residual depressive symptoms, measured using the Beck Depression Inventory and the cortisol awakening response were measured immediately before and after completion of the bias modification and then again after 4 weeks' follow-up.

Results: Positive, face-based ABM reduced both measures of recurrence risk (Beck Depression Inventory and cortisol awakening response). This effect occurred during the month following completion of bias modification. Word-based modification did not influence the outcome measures.

Conclusions: Positive face-based ABM was able to reduce intermediate measures of recurrence risk in previously depressed patients. These results suggest that ABM may provide a "cognitive vaccine" against depression and offer a useful strategy in the secondary prevention of the illness.

Copyright © 2012 Society of Biological Psychiatry. Published by Elsevier Inc. All rights reserved.

Figures

Figure 1
Figure 1
Study design and attentional bias modification (ABM) task used. (A) Patients completed three assessment sessions, immediately before and after 2 weeks of ABM and then again a month later. The assessment measures completed during both sessions are listed. (B) Each participant was randomly assigned to one of four treatment groups using a factorial design. This design allows assessment of the main effects of both ABM type and the stimuli used in ABM as well any interaction between the two. (C) Two example trials from the ABM task completed by patients. On each trial two stimuli were presented, followed by a probe (one or two dots) to which the patients had to respond. During positive ABM (shown) the probe appeared behind the more positive of the two stimuli; the placebo ABM condition was identical in every respect other than that the probe was equally likely to appear behind either stimulus. The stimuli used during ABM were either faces (shown) or words.
Figure 2
Figure 2
The effects of attentional bias modification (ABM) on residual symptoms of depression measured using the BDI (A, B) and the HRSD (C, D) and on symptoms of anxiety measured using the trait-STAI (E, F). Symptoms, which are displayed as a change from baseline of the mean scores, were measured at three time points; before bias modification, after bias modification, and after 1-month follow-up. The symptoms of both depression and anxiety were significantly altered by face- but not word-based ABM. The effect of ABM occurred during follow-up with no difference in groups seen during the bias modification period. Solid line, positive ABM; dashed line, placebo ABM. Error bars represent SEM. *p < .05 for post hoc test of interaction. BDI, Beck Depression Inventory; HRSD, Hamilton Rating Scale for Depression; Trait-STAI, the trait subscale of the Spielberger State-Trait Anxiety Inventory.
Figure 3
Figure 3
The effects of attentional bias modification (ABM) on cortisol awakening response (CAR). Results display the change from baseline of the mean CAR measured before bias modification, after bias modification, and after 1-month follow-up. Face-based ABM (A) produced a significant effect on CAR, whereas word-based ABM (B) had no effect. Again, the effect of face ABM was seen during the follow-up period. Solid line, positive ABM; dashed line, placebo ABM. Error bars represent standard error of the mean. *p < .05 for post hoc test of interaction.
Figure 4
Figure 4
The effects of attentional bias modification (ABM) on attentional vigilance to word stimuli measured using the visual probe task. Vigilance is calculated so that a greater positive number represents increased vigilance for the positive stimulus, whereas a negative number represents vigilance for the negative stimulus. Results display the change from baseline of the mean attentional bias measured before bias modification, after bias modification, and after 1-month follow-up. Positive face-based ABM (A) produced a significant increase in vigilance toward the positive stimuli, whereas placebo word-based ABM (B) resulted in a trend-level decrease in vigilance. Unlike the measures of recurrence risk (Figures 2 and 3), the effect of ABM was seen during the bias modification period. Solid line, positive ABM; dashed line, placebo ABM. Error bars represent standard error of the mean. *p < .05 for post hoc test.

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