Evaluation of a mobile phone-based, advanced symptom management system (ASyMS) in the management of chemotherapy-related toxicity
N Kearney, L McCann, J Norrie, L Taylor, P Gray, M McGee-Lennon, M Sage, M Miller, R Maguire, N Kearney, L McCann, J Norrie, L Taylor, P Gray, M McGee-Lennon, M Sage, M Miller, R Maguire
Abstract
Objectives: To evaluate the impact of a mobile phone-based, remote monitoring, advanced symptom management system (ASyMS) on the incidence, severity and distress of six chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea) in patients with lung, breast or colorectal cancer.
Design: A two group (intervention and control) by five time points (baseline, pre-cycle 2, pre-cycle 3, pre-cycle 4 and pre-cycle 5) randomised controlled trial.
Setting: Seven clinical sites in the UK; five specialist cancer centres and two local district hospitals.
Participants: One hundred and twelve people with breast, lung or colorectal cancer receiving outpatient chemotherapy.
Interventions: A mobile phone-based, remote monitoring, advanced symptom management system (ASyMS).
Main outcome measures: Chemotherapy-related morbidity of six common chemotherapy-related symptoms (nausea, vomiting, fatigue, mucositis, hand-foot syndrome and diarrhoea).
Results: There were significantly higher reports of fatigue in the control group compared to the intervention group (odds ratio = 2.29, 95%CI = 1.04 to 5.05, P = 0.040) and reports of hand-foot syndrome were on average lower in the control group (odds ratio control/intervention = 0.39, 95%CI = 0.17 to 0.92, P = 0.031).
Conclusion: The study demonstrates that ASyMS can support the management of symptoms in patients with lung, breast and colorectal cancer receiving chemotherapy.
References
- Eur J Oncol Nurs. 2008 Sep;12(4):380-6
- CMAJ. 2001 Sep 18;165(6):765-71
- Eur J Heart Fail. 2003 Oct;5(5):583-90
- Cancer. 1986 Aug 1;58(3):796-800
- J Allergy Clin Immunol. 2005 Jun;115(6):1137-42
- Cancer. 2006 May 15;106(10):2258-66
- Cancer Pract. 2002 May-Jun;10(3):147-54
- J Pain Symptom Manage. 1995 Oct;10(7):510-20
- Chemotherapy. 2004 Oct;50(4):157-61
- Comput Methods Programs Biomed. 2002 Aug;69(2):137-46
- Oncol Nurs Forum. 1988 May-Jun;15(3):325-30
- Control Clin Trials. 2002 Dec;23(6):662-74
- J Clin Oncol. 2002 Dec 15;20(24):4636-42
- Int J Palliat Nurs. 2008 Sep;14(9):426-31
- Eur J Cancer Care (Engl). 2009 Mar;18(2):156-64
- Eur J Oncol Nurs. 2007 Jul;11(3):238-46
- Support Care Cancer. 2006 Jul;14(7):742-52
- Am J Health Syst Pharm. 2004 Apr 1;61(7):722-3
- Eval Health Prof. 2005 Dec;28(4):464-78
- Can J Gastroenterol. 2005 Feb;19(2):83-7
- Semin Hematol. 1997 Jul;34(3 Suppl 2):4-12
- Lancet. 2003 Aug 23;362(9384):640-50
- Soc Sci Med. 2003 Aug;57(4):697-710
- J Telemed Telecare. 2005;11 Suppl 1:43-6
- Int J Nurs Stud. 2001 Oct;38(5):497-510
- Cancer Causes Control. 2006 Jun;17(5):647-54
- Am J Manag Care. 2006 Aug;12(8):467-74
Source: PubMed