Neurologic and Radiographic Findings Associated With COVID-19 Infection in Children

Abstract

Importance: Neurological manifestations have been reported in adults with coronavirus disease 2019 (COVID-19), which is caused by the highly pathogenic virus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

Objective: To report the neurological manifestations of children with COVID-19.

Design, setting, and participants: In this case-series study, patients younger than 18 years who presented with SARS-CoV-2 infection and neurological symptoms to Great Ormond Street Hospital for Children (London, UK) between March 1, 2020, and May 8, 2020, were included after infection was confirmed by either a quantitative reverse transcription-polymerase chain reaction assay by nasopharyngeal swab or a positive test result for IgG antibodies against SARS-CoV-2 in serum.

Main outcomes and measures: Clinical and paraclinical features were retrieved from electronic patient records.

Results: Of the 27 children with COVID-19 pediatric multisystem inflammatory syndrome, 4 patients (14.8%) who were previously healthy had new-onset neurological symptoms. Symptoms included encephalopathy, headaches, brainstem and cerebellar signs, muscle weakness, and reduced reflexes. All 4 patients required intensive care unit admission for the treatment of COVID-19 pediatric multisystem inflammatory syndrome. Splenium signal changes were seen in all 4 patients on magnetic resonance imaging of the brain. In the 2 patients whose cerebrospinal fluid was tested, samples were acellular, with no evidence of infection on polymerase chain reaction or culture (including negative SARS-CoV-2 polymerase chain reaction results) and negative oligoclonal band test results. In all 3 patients who underwent electroencephalography, a mild excess of slow activity was found. Tests for N-methyl-d-aspartate receptor, myelin oligodendrocyte glycoprotein, and aquaporin-4 autoantibodies had negative results in all patients. In all 3 patients who underwent nerve conduction studies and electromyography, mild myopathic and neuropathic changes were seen. Neurological improvement was seen in all patients, with 2 making a complete recovery by the end of the study.

Conclusions and relevance: In this case-series study, children with COVID-19 presented with new neurological symptoms involving both the central and peripheral nervous systems and splenial changes on imaging, in the absence of respiratory symptoms. Additional research is needed to assess the association of neurological symptoms with immune-mediated changes among children with COVID-19.

Conflict of interest statement

Conflict of Interest Disclosures: Dr Hemingway has received educational and travel grants from Merck Serono and Bayer and Biogen. Dr Eyre reported personal fees from Terumo BCT outside the submitted work. No other disclosures were reported.

Figures

Figure.. Neuroimaging Findings in Association With Coronavirus Disease 2019 in Children

A, Computed tomography image of patient 1 on day 5 (top), during intensive care admission, showing hypodensity of the splenium of the corpus collosum (SCC). Coronal fluid-attenuated inversion recovery performed on day 12 (bottom) shows resolution of the changes previously seen on computed tomography, with persistent signal changes in the genu and SCC without restricted diffusion (not shown). B, Axial T2 magnetic resonance image of patient 2 on day 1, showing signal changes of the genu and SCC (top) and bilateral centrum semiovale with restricted diffusion (bottom). Repeated imaging on day 6 (not shown) demonstrated resolution of the restricted diffusion, with minimal signal changes remaining on T2-weighted imaging. C, Axial T2 magnetic resonance imaging of patient 3 on day 21, showing hyperintensities (top) with restricted diffusion (bottom) in the SCC and bilateral centrum semiovale (not shown). D, Axial T2 magnetic resonance imaging of patient 4 on day 5 (top), showing signal change in the SCC with mild restricted diffusion (bottom).