Efficacy of early interventions for infants and young children with, and at risk for, autism spectrum disorders

Rebecca J Landa, Rebecca J Landa

Abstract

With advances in the field's ability to identify autism spectrum disorders (ASD) at younger ages, the need for information about the evidence-base for early intervention continues to rise. This review of the ASD early intervention (EI) literature focuses on efficacy studies published within the past 15 years. The neurodevelopmental context for early intervention, timing of initiating intervention, primary intervention approaches, and predictors of treatment outcomes are discussed. The evidence indicates that young children with ASD benefit from EI, and their parents learn to implement child-responsive engagement strategies when a parent-coaching intervention is provided. Evidence supports combining parent-mediated and direct clinician-implemented intervention to maximize child developmental gains. Clinical practice recommendations are presented, based on the literature reviewed.

Keywords: Autism spectrum disorders; early intervention; efficacy.

Conflict of interest statement

Disclosure statement

The author reports no conflicts of interest. The author alone is responsible for the content and writing of the paper.

References

    1. Aldred CR, Green J, Adams C. A new social communication intervention for children with autism: Pilot randomised controlled treatment study suggesting effectiveness. Journal of Child Psychology and Psychiatry. 2004;45:1420–1430. doi: 10.1111/j.1469-7610.2004.00338.x.
    1. American Psychiatric Association. Diagnostic and statistical manual fifth edition. Washington DC: American Psychiatric Association; 2013.
    1. Baranek GT. Autism during infancy: A retrospective video analysis of sensory-motor and social behaviors at 9–12 months of age. Journal of Autism and Developmental Disorders. 1999;29:213–224. doi: 10.1023/A:1023080005650.
    1. Baranek GT, Watson LR, Turner-Brown L, Field SH, Crais ER, Wakeford L, Reznick JS. Preliminary efficacy of adapted responsive teaching for infants at risk of autism spectrum disorder in a community sample. Autism Research and Treatment. 2015;2015:386951. doi: 10.1155/2015/386951.
    1. Beaudoin AJ, Sébire G, Couture M. Parent training interventions for toddlers with autism spectrum disorder. Autism Research and Treatment. 2014;2014:839890. doi: 10.1155/2014/839890.
    1. Bhat AN, Galloway JC, Landa RJ. Social and non-social visual attention patterns and associative learning in infants at risk for autism. Journal of Child Psychology and Psychiatry and Allied Disciplines. 2010;51:989–997. doi: 10.1111/j.1469-7610.2010.02262.x.
    1. Bhat AN, Galloway JC, Landa RJ. Relation between early motor delay and later communication delay in infants at risk for autism. Infant Behavior and Development. 2012;35:838–846. doi: 10.1016/j.infbeh.2012.07.019.
    1. Cannon EN, Yoo KH, Vanderwert RE, Ferrari PF, Woodward AL, Fox NA. Action experience, more than observation, influences mu rhythm desynchronization. PloS One. 2014;9:e92002. doi: 10.1371/journal.pone.0092002.
    1. Carter AS, Messinger DS, Stone WL, Celimli S, Nahmias AS, Yoder P. A randomized controlled trial of Hanen’s ‘More Than Words’ in toddlers with early autism symptoms. Journal of Child Psychology and Psychiatry. 2011;52:741–752. doi: 10.1111/j.1469-7610.2011.02395.x.
    1. Casenhiser DM, Shanker SG, Stieben J. Learning through interaction in children with autism: Preliminary data from a social-communication-based intervention. Autism. 2013;17:220–241. doi: 10.1177/1362361311422052.
    1. Charman T, Young GS, Brian J, Carter A, Carver LJ, Chawarska K, Zwaigenbaum L. Non-ASD outcomes at 36 months in siblings at familial risk for autism spectrum disorder (ASD): A baby siblings research consortium (BSRC) study. Autism Research. 2017;10:169–178. doi: 10.1002/aur.1669.
    1. Chawarska K, Macari S, Shic F. Decreased spontaneous attention to social scenes in 6-month-old infants later diagnosed with autism spectrum disorders. Biological Psychiatry. 2013;74:195–203. doi: 10.1016/j.biopsych.2012.11.022.
    1. Christensen DL, Bilder DA, Zahorodny W, Pettygrove S, Durkin MS, Fitzerald RT, Yeargin-Allsopp M. Prevalence and characteristics of autism spectrum disorder among 4-year-old children in the Autism and developmental disabilities monitoring network. Journal of Developmental and Behavioral Pediatrics. 2016;37:1–8.
    1. Darcy-Mahoney A, Minter B, Higgins M, Guo Y, Williams B, Head Zauche LM, Birth K. Probability of an autism diagnosis by gestational age. Newborn and Infant Nursing Reviews. 2016;16:322–326. doi: 10.1053/j.nainr.2016.09.019.
    1. Dawson G, Rogers S, Munson J, Smith M, Winter J, Greenson J, Varley J. Randomized, controlled trial of an intervention for toddlers with autism: The early start denver model. Pediatrics. 2010;125:e17–e23. doi: 10.1542/peds.2009-0958.
    1. Division for Early Childhood (DEC) DEC recommended practices in early intervention/early childhood special education 2014. 2014 Retrieved from .
    1. Drew A, Baird G, Baron-Cohen S, Cox A, Slonims V, Wheelwright S, Charman T. A pilot randomised control trial of a parent training intervention for pre-school children with autism: Preliminary findings & methodological challengers. European Child and Adolescent Psychiatry. 2002;11:266–272. doi: 10.1007/s00787-002-0299-6.
    1. Eikeseth S, Klintwall L, Jahr E, Karlsson P. Outcome for children with autism receiving early and intensive behavioral intervention in mainstream preschool and kindergarten settings. Research in Autism Spectrum Disorders. 2012;6:829–835. doi: 10.1016/j.rasd.2011.09.002.
    1. Eikeseth S, Smith T, Jahr E, Eldevik S. Outcome for children with autism who began intensive behavioral treatment between ages 4 and 7: A comparison controlled study. Behavior Modification. 2007;31:264–278. doi: 10.1177/0145445506291396.
    1. Eldevik S, Hastings RP, Hughes JC, Jahr E, Eikeseth S, Cross S. Meta-analysis of early intensive behavioral intervention for children with autism. Journal of Clinical Child and Adolescent Psychology. 2009;38:439–450. doi: 10.1080/15374410902851739.
    1. Eldevik S, Hastings RP, Hughes JC, Jahr E, Eikeseth S, Cross S. Using participant data to extend the evidence base for intensive behavioral intervention for children with autism. American Journal on Intellectual and Developmental Disabilities. 2010;115:381–405. doi: 10.1352/1944-7558-115.5.381.
    1. Eldevik S, Hastings RP, Jahr E, Hughes JC. Outcomes of behavioral intervention for children with autism in mainstream pre-school settings. Journal of Autism and Developmental Disorders. 2012;42:210–220. doi: 10.1007/s10803-011-1234-9.
    1. Elison JT, Paterson SJ, Wolff JJ, Reznick JS, Sasson NJ, Gu H IBIS Network. White matter microstructure and atypical visual orienting in 7-month-olds at risk for autism. The American Journal of Psychiatry. 2013;170:899–908.
    1. Fernell E, Hedvall A, Westerlund J, Carlsson LH, Eriksson M, Olsson MB, Gillberg C. Early intervention in 208 Swedish preschoolers with autism spectrum disorder. A prospective naturalistic study. Research in Developmental Disabilities. 2011;32:2092–2101. doi: 10.1016/j.ridd.2011.08.002.
    1. Flanagan JE, Landa RJ, Bhat A, Bauman M. Head lag in infants at risk for autism: A preliminary study. American Journal of Occupational Therapy. 2012;66:577–585. doi: 10.5014/ajot.2012.004192.
    1. Frost L, Bondy A. The Picture Exchange Communication System (PECS) training manual. 2. Newark, DE: Pyramid Publications; 2002.
    1. Ganz JB, Mason RA, Goodwyn FD, Boles MB, Heath AK, Davis JL. Interaction of participant characteristics and type of AAC with individuals with ASD: A meta-analysis. American Journal on Intellectual and Developmental Disabilities. 2014;119:516–535. doi: 10.1352/1944-7558-119.6.516.
    1. Green J, Charman T, McConachie H, Aldred C, Slonims V, Howlin P The PACT Consortium. Parent-mediated communication-focused treatment in children with autism (PACT): A randomised controlled trial. The Lancet. 2010;375:2152–2160. doi: 10.1016/s0140-6736(10)60587-9.
    1. Green J, Charman T, Pickles A, Wan M, Elsabbagh M, Slonims V The BASIS team. Parent-mediated intervention versus no intervention for infants at high risk of autism: A parallel, single-blind, randomised trial. The Lancet Psychiatry. 2015;2:133–140. doi: 10.1016/S2215-0366(14)00091-1.
    1. Green J, Pickles A, Pasco G, Bedford R, Wan MW, Elsabbagh M The BASIS Team. Randomised trial of a parent-mediated intervention for infants at high risk for autism: longitudinal outcomes to age 3 years. Journal of Child Psychology and Psychiatry. 2017;58:1330–1340. doi: 10.1111/jcpp.12728. Advance Online Publication.
    1. Green J, Wan MW, Guiraud J, Holsgrove S, McNally J, Slonims V The BASIS Team. Intervention for infants at risk of developing autism: A case series. Journal of Autism and Developmental Disorders. 2013;43:2502–2514. doi: 10.1007/s10803-013-1797-8.
    1. Gulsrud AC, Hellemann GS, Freeman SFN, Kasari C. Two to ten years: Developmental trajectories of joint attention in children with ASD who received targeted social communication interventions. Autism Research. 2014;7:207–215. doi: 10.1002/aur.1360.
    1. Hampton LH, Kaiser AP. Intervention effects on spoken-language outcomes for children with autism: A systematic review and meta-analysis. Journal of Intellectual Disability Research. 2016;60:444–463. doi: 10.1111/jir.12283.
    1. Hardan AY, Gengoux GW, Berquist KL, Libove RA, Ardel CM, Phillips J, Minjarez MB. A randomized controlled trial of pivotal response treatment group for parents of children with autism. Journal of Child Psychology and Psychiatry. 2014;56:884–892. doi: 10.1111/jcpp.12345.
    1. Hayward D, Eikeseth S, Gale C, Morgan S. Assessing progress during treatment for young children with autism receiving intensive behavioural interventions. Autism. 2009;13:613–633. doi: 10.1177/1362361309340029.
    1. Howlin P, Magiati I, Charman T. Systematic review of early intensive behavior interventions for children with autism. American Journal on Intellectual and Developmental Disabilities. 2009;114:23–41. doi: 10.1352/2009.114:23-41.
    1. Ingersoll B. Brief report: Pilot randomized controlled trial of reciprocal imitation training for teaching elicited and spontaneous imitation to children with autism. Journal of Autism and Developmental Disorders. 2010;40:1154–1160. doi: 10.1007/s10803-010-0966-2.
    1. Ingersoll B, Gergans S. The effect of a parent-implemented naturalistic imitation intervention on spontaneous imitation skills in young children with autism. Research in Developmental Disabilities. 2007;28:163–175. doi: 10.1016/j.ridd.2006.02.004.
    1. Johnson MH, Griffin R, Csibra G, Halit H, Farroni T, De Haan M, Richards J. The emergence of the social brain network: Evidence from typical and atypical development. Developmental Psychopathology. 2005;17:599–619. doi: 10.1017/S0954579405050297.
    1. Juffer F, Bakermans-Kranenburg MJ, van IJzendoorn MH, editors. Promoting positive parenting: An attachment-based intervention. New York, NY: Taylor and Francis Group/Lawrence Erlbaum Associates; 2008.
    1. Kaale A, Smith L, Sponheim E. A randomized controlled trial of preschool-based joint attention intervention for children with autism. Journal of Child Psychology and Psychiatry. 2012;53:97–105. doi: 10.1111/j.1469-7610.2011.02450.x.
    1. Kaplan G, McCracken JT. Psychopharmacology of autism spectrum disorders. Pediatric Clinics of North America. 2012;59:175–187. doi: 10.1016/j.pcl.2011.10.005.
    1. Karmiloff-Smith A. An alternative to domain-general or domain-specific frameworks for theorizing about human evolution and ontogenesis. AIMS Neuroscience. 2015;2:91–104. doi: 10.3934/Neuroscience.2015.2.91.
    1. Karmiloff-Smith A, Casey BJ, Massand E, Tomalski P, Thomas MS. Environmental and genetic influences on neurocognitive development: The importance of multiple methodologies and time-dependent intervention. Clinical Psychological Science: A Journal of the Association for Psychological Science. 2014;2:628–637. doi: 10.1177/2167702614521188.
    1. Kasari C, Freeman S, Paparella T. Joint attention and symbolic play in young children with autism: A randomized controlled intervention study. Journal of Child Psychology and Psychiatry. 2006;47:611–620. doi: 10.1111/j.1469-7610.2005.01567.x.
    1. Kasari C, Gulsrud A, Freeman S, Paparella T, Hellemann G. Longitudinal follow-up of children with autism receiving targeted interventions on joint attention and play. Journal of the American Academy of Child Adolescent Psychiatry. 2012;51:487–495. doi: 10.1016/j.jaac.2012.02.019.
    1. Kasari C, Gulsrud A, Paparella T, Hellemann G, Berry K. Randomized comparative efficacy study of parent-mediated interventions for toddlers with autism. Journal of Consulting and Clinical Psychology. 2015;83:554–563. doi: 10.1037/a0039080.
    1. Kasari C, Gulsrud AC, Wong C, Kwon S, Locke J. Randomised controlled caregiver mediated joint engagement intervention for toddlers with autism. Journal of Autism and Developmental Disorders. 2010;40:1045–1056. doi: 10.1007/s10803-010-0955-5.
    1. Klintwall L, Eikeseth S. Number and controllability of reinforcers as predictors of individual outcome for children with autism receiving early and intensive behavioral intervention: A preliminary study. Research in Autism Spectrum Disorders. 2012;6:493–499. doi: 10.1016/j.rasd.2011.07.009.
    1. Koegel LK, Singh AK, Koegel RL, Hollingsworth JR, Bradshaw J. Assessing and improving early social engagement in infants. Journal of Positive Behavior Interventions. 2013;16:69–80. doi: 10.1177/1098300713482977.
    1. Koegel R, Koegel L. Pivotal response treatments for autism. Baltimore, MD: Brookes Publishing Co; 2006.
    1. Kolb B, Gibb R. Brain plasticity and behaviour in the developing brain. Journal of the Canadian Academy of Child & Adolescent. 2011;20:265–276. Retrieved from .
    1. Landa RJ, Kalb LG. Long-term outcomes of toddlers with autism spectrum disorders exposed to short-term intervention. Pediatrics. 2012;130:S186–S190. doi: 10.1542/peds.2012-0900Q.
    1. Landa RJ, Gross AL, Stuart EA, Faherty A. Developmental trajectories in children with and without autism spectrum disorders: The first 3 years. Child Development. 2013;84:429–442. doi: 10.1111/j.1467-8624.2012.01870.x.
    1. Landa RJ, Holman KC, Garrett-Mayer E. Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Archives of General Psychiatry. 2007;64:835–864. doi: 10.1001/archpsyc.64.7.853.
    1. Landa RJ, Holman KC, O’Neill AH, Stuart EA. Intervention targeting development of socially synchronous engagement in toddlers with autism spectrum disorder: A randomized controlled trial. Journal of Child Psychology and Psychiatry. 2011;52:13–21. doi: 10.1111/j.1469-7610.2010.02288.x.
    1. Lane JD, Lieberman-Betz R, Gast D. An analysis of naturalistic interventions for increasing spontaneous expressive language in children with autism spectrum disorder. Journal of Special Education. 2016;50:49–61. doi: 10.1177/0022466915614837.
    1. Lovaas OI. Behavioral treatment and normal educational and intellectual functioning in young autistic children. Journal of Consulting and Clinical Psychology. 1987;57:3–9. doi: 10.1037/0022-006X.55.1.3.
    1. Magiati I, Charman T, Howlin P. A two-year prospective follow-up study of community-based early intensive behavioral intervention and specialist nursery provision for children with autism spectrum disorders. Journal of Child Psychology and Psychiatry. 2007;48:803–812. doi: 10.1111/j.1469-7610.2007.01756.x.
    1. Mahoney G, Solomon R. Mechanism of developmental change in the PLAY project home consultation program: Evidence from a randomized control trial. Journal of Autism and Developmental Disorders. 2016;46:1860–1871. doi: 10.1007/s10803-016-2720-x.
    1. Oono IP, Honey EJ, McConachie H. Parentmediated early intervention for young children with autism spectrum disorders (ASD) Evidence-Based Child Health. 2013;8:2380–2479. doi: 10.1002/ebch.1952.
    1. Oosterling I, Visser J, Swinkels S, Rommelse N, Donders R, Woudenberg T, Buitelaar J. Randomized control trial of the focus parent training for toddlers with autism: 1-year outcome. Journal of Autism and Developmental Disorders. 2010;40:1447–1458. doi: 10.1007/s10803-010-1004-0.
    1. Ozonoff S, Young GS, Carter A, Messinger D, Yirmiya N, Zwaigenbaum L, Stone WL. Recurrence risk for autism spectrum disorders: A baby siblings research consortium study. Pediatrics. 2011;128:e488–e495. doi: 10.1542/peds.2017-2954.
    1. Ozonoff S, Young GS, Landa RJ, Brian J, Bryson S, Charman T, Iosif AM. Diagnostic stability in young children at risk for autism spectrum disorder: A baby siblings research consortium study. Journal of Child Psychology and Psychiatry. 2015;56:988–998. doi: 10.1111/jcpp.12421.
    1. Peters-Scheffer N, Didden R, Mulders M, Korzilius H. Low intensity behavioral treatment supplementing preschool services for young children with autism spectrum disorders and severe to mild intellectual disability. Research in Developmental Disabilities. 2010;31:1678–1684. doi: 10.1016/j.ridd.2010.04.008.
    1. Pickles A, Le Couteur A, Leadbitter K, Salomone E, Cole-Fletcher R, Tobin H, Green J. Parent-mediated social communication therapy for young children with autism (PACT): Long-term follow-up of a randomised controlled trial. The Lancet. 2016;388:2501–2509. doi: 10.1016/S0140-6736(16)31229-6.
    1. Piven J, Elison JT, Zylka MJ. Toward a conceptual framework for early brain and behavior development in autism. Molecular Psychiatry. 2017;22:1385–1394. doi: 10.1038/mp.2017.131.
    1. Poslawsky IE, Naber FBA, Bakermans-Kranenburg MJ, van Daalen E, van Engeland H, van IJzendoorn MH. Video-feedback intervention to promote positive parenting adapted to autism (VIPP-AUTI): A randomized controlled trial. Autism. 2015;19:588–603. doi: 10.1177/1362361314537124.
    1. Reichow B. Overview of meta-analyses on early intensive behavioral interventions for children with autism spectrum disorders. Journal of Autism and Developmental Disorders. 2012;42:512–520. doi: 10.1007/s10803-011-1218-9.
    1. Reichow B, Barton EE, Boyd BA, Hume K. Early intensive behavioral intervention (EIBI) for young children with autism spectrum disorders (ASD) Cochrane Database of Systematic Reviews. 2012;10:CD009260. doi: 10.1002/14651858.cd009260.pub2.
    1. Rickards AL, Walstab JE, Wright-Rossi RA, Simpson J, Reddihough D. A randomized, controlled trial of a home-based intervention program for children with autism and developmental delay. Journal of Developmental & Behavioral Pediatrics. 2007;28:308–316. doi: 10.1097/DBP.0b013e318032792e.
    1. Roberts J, Williams K, Carter M, Evans D, Parmenter T, Silove N, Warren A. A randomised controlled trial of two early intervention programs for young children with autism: Centre-based with parent program and home-based. Research in Autism Spectrum Disorders. 2011;5:1553–1566. doi: 10.1016/j.rasd.2011.03.001.
    1. Rogers SJ, Vismara LA. Evidence-based comprehensive treatments for early autism. Journal of Clinical Child and Adolescent Psychology. 2008;37:8–38. doi: 10.1080/15374410701817808.
    1. Rogers SJ, Estes A, Lord C, Vismara L, Winter J, Fitzpatrick A, Dawson G. Effects of a brief Early Start Denver Model (ESDM)-based parent intervention on toddlers at risk for autism spectrum disorders: A randomized controlled trial. Journal of the American Academy of Child & Adolescent Psychiatry. 2012;51:1052–1065. doi: 10.1016/j.jaac.2012.08.003.
    1. Rogers SJ, Vismara L, Wagner AL, McCormick C, Young G, Ozonoff S. Autism treatment in the first year of life: A pilot study of Infant Start, a parent-implemented intervention for symptomatic infants. Journal of Autism and Developmental Disorders. 2014;44:2981–2995. doi: 10.1007/s10803-014-2202-y.
    1. Sallows GO, Graupner TD. Intensive behavioral treatment for children with autism: Four-year outcome and predictors. American Journal on Mental Retardation. 2005;110:417–438. doi: 10.1352/0895-8017(2005)110[417:IBTFCW];2.
    1. Salmond CH, Vargha-Khadem F, Gadian DG, De Haan M, Baldeweg T. Heterogeneity in the patterns of neural abnormaility in autistic spectrum disorders: Evidence from ERP and MRI. Cortex. 2007;43:686–699. doi: 10.1016/S0010-9452(08)70498-2.
    1. Schertz HH, Odom SL. Promoting joint attention in toddlers with autism: A parent-mediated developmental model. Journal of Autism and Developmental Disorders. 2007;37:1562–1575. doi: 10.1007/s10803-006-0290-z.
    1. Schertz HH, Odom SL, Baggett KM, Sideris JH. Effects of joint attention mediated learning for toddlers with autism spectrum disorders: An initial randomized controlled study. Early Childhood Research Quarterly. 2013;28:249–258. doi: 10.1016/j.ecresq.2012.06.006.
    1. Schlosser RW, Wendt O. Effects of augmentative and alternative communication intervention on speech production in children with autism: A systematic review. American Journal of Speech-Language Pathology. 2008;17:212–230. doi: 10.1044/1058-0360(2008/021).
    1. Schriebman L, Dawson G, Stahmer AC, Landa R, Rogers SJ, McGee GG, Halladay A. Naturalistic developmental behavioral interventions: Empirically validated treatments for autism spectrum disorder. Journal of Autism and Developmental Disorders. 2015;45:2411–2428. doi: 10.1007/s10803-015-2407-8.
    1. Shire SY, Gulsrud A, Kasari C. Increasing responsive parent-child interactions and joint engagement: Comparing the influence of parent-mediated intervention and parent psychoeducation. Journal of Autism and Developmental Disorders. 2016;46:1737–1747. doi: 10.1007/s10803-016-2702-z.
    1. Siller M, Hutman T, Sigman M. A parent-mediated intervention to increase responsive parental behaviors and child communication in children with ASD: A randomized clinical trial. Journal of Autism and Developmental Disorders. 2013;43:540–555. doi: 10.1007/s10803-012-1584-y.
    1. Smith T. Applied behavior analysis and early intensive intervention. In: Amaral DG, Dawson G, Geschwind DH, editors. Autism spectrum disorders. New York, NY: Oxford University Press; 2011. pp. 1037–1055.
    1. Smith T, Groen AD, Wynn JW. Randomized trial of intensive early intervention for children with pervasive developmental disorder. American Journal on Mental Retardation. 2000;105:269–285. doi: 10.1352/0895-8017(2000)105<0269:RTOIEI>;2.
    1. Smith T, Iadarola S. Evidence base update for autism spectrum disorder. J Clin Child Adolesc Psychol. 2015;44:897–922. doi: 10.1080/15374416.2015.1077448.
    1. Smith T, Klorman R, Mruzek D. Predicting outcome of community-based early intensive behavioral intervention for children with autism. Journal of Abnormal Child Psychology. 2015;43:1271–1282. doi: 10.1007/s10802-015-0002-2.
    1. Solomon R, Van Egeren LA, Mahoney G, Quon Huber MS, Zimmerman P. PLAY project home consultation intervention program for young children with autism spectrum disorders: A randomized controlled trial. Journal of Developmental and Behavioral Pediatrics. 2014;35:475–485. doi: 10.1097/DBP.0000000000000096.
    1. Stahmer AC, Rieth S, Lee E, Reisinger EM, Mandell DS, Connell JE. Training teachers to use evidence-based practices for autism: Examining procedural implementation fidelity. Psychology in the Schools. 2015;52:181–195. doi: 10.1002/pits.21815.
    1. Steiner AM, Gengoux GW, Klin A, Chawarska K. Pivotal response treatment for infants at-risk for autism spectrum disorders: A pilot study. Journal of Autism and Developmental Disorders. 2013;43:91–102. doi: 10.1007/s10803-012-1542-8.
    1. Strain P, Bovey EH. Randomized, controlled trial of the LEAP model of early intervention for young children with autism spectrum disorders. Topics in Early Childhood Special Education. 2011;31:133–154. doi: 10.1177/0271121411408740.
    1. Strauss K, Vicari S, Valeri G, D’elia L, Arima S, Fava L. Parent inclusion in early intensive behavior intervention: The influence of parental stress, parent treatment fidelity and parent-medicated generalization of behavior targets on child outcomes. Research in Developmental Disabilities. 2012;33:688–703. doi: 10.1016/j.ridd.2011.11.008.
    1. Twardzik E, Cotto-Negrón C, MacDonald M. Factors related to early intervention Part C enrollment: A systematic review. Disability and Health Journal. 2017;10:467–474. doi: 10.1016/j.dhjo.2017.01.009.
    1. Virués-Ortega J. Applied behavior analytic intervention for autism in early childhood: Meta-analysis, meta-regression and dose–response meta-analysis of multiple outcomes. Clinical Psychology Review. 2010;30:387–399. doi: 10.1016/j.cpr.2010.01.008.
    1. Virués-Ortega J, Rodriguez V, Yu CT. Prediction of treatment outcomes and longitudinal analysis in children with autism undergoing intensive behavioral intervention. International Journal of Clinical and Health Psychology. 2013;13:91–100. doi: 10.1016/S1697-2600(13)70012-7.
    1. Vivanti G, Dissanayake C, Zierhut C, Rogers SJ Victorian ASELCC Team. Brief report: predictors of outcomes in the early start denver model delivered in a group setting. Journal of Autism and Developmental Disorders. 2013;43:1717–1724. doi: 10.1007/s10803-012-1705-7.
    1. Wallace KS, Rogers SJ. Intervening in infancy: Implications for autism spectrum disorders. J Child Psychol Psychiatry. 2010;51:1300–1320. doi: 10.1111/j.1469-7610.2010.02308.x.
    1. Warren ZE, McPheeters ML, Sathe NA, Foss-Feig JH, Glasser A, Veenstra-VanderWeele J. A systematic review of early intensive intervention for autism spectrum disorders. Pediatrics. 2011;127:e1303–e1311. doi: 10.1542/peds.2011-0426.
    1. Watson LR, Crais ER, Baranek GT, Turner-Brown L, Sideris J, Wakeford L, Nowell SW. Parent-mediated intervention for one-year-olds screened as at-risk for autism spectrum disorder: A randomized controlled trial. Journal of Autism and Developmental Disorders. 2017;47:3520–3540.
    1. Weisen S, Watkins RM, Needham A. Active motor training has long-term effects on infants' object exploration. Frontiers in Psychology. 2016;7:599. doi: 10.3389/fpsyg.2016.00599.
    1. Wetherby AM, Guthrie W, Woods J, Schatschneider C, Holland RD, Morgan L, Lord C. Parent-implemented social intervention for toddlers with autism: An RCT. Pediatrics. 2014;134:1084–1093. doi: 10.1542/peds.2014-0757.
    1. Yoder P, McDuffie A. Teaching young children with autism to talk. Seminars in Speech and Language. 2006;27:161–172. doi: 10.1055/s-2006-948227.
    1. Zachor DA, Ben-Itzchak E. Variables affecting outcome of early intervention in autism spectrum disorder. Journal of Pediatric Neurology. 2017;15:129–133. doi: 10.1055/s-0037-1601444.

Source: PubMed

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