COVID fog demystified

Jennifer Kao, Paul W Frankland, Jennifer Kao, Paul W Frankland

Abstract

Acute mild respiratory SARS-CoV-2 infection can lead to a more chronic cognitive syndrome known as "COVID fog." New findings from Fernández-Castañeda et al. reveal how glial dysregulation and consequent neural circuit dysfunction may contribute to cognitive impairments in long COVID.

Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Copyright © 2022. Published by Elsevier Inc.

Figures

Figure 1
Figure 1
The neuroinflammatory basis of COVID fog Acute mild respiratory COVID-19 infection can lead to a more chronic cognitive syndrome known as brain fog. Suggested pathways for brain fog include cytokine-induced activation of regional microglia, causing decreased hippocampal neurogenesis and a loss of myelinated subcortical axons.

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