Artificial Intelligence in Anesthesiology: Current Techniques, Clinical Applications, and Limitations

Daniel A Hashimoto, Elan Witkowski, Lei Gao, Ozanan Meireles, Guy Rosman, Daniel A Hashimoto, Elan Witkowski, Lei Gao, Ozanan Meireles, Guy Rosman

Abstract

Artificial intelligence has been advancing in fields including anesthesiology. This scoping review of the intersection of artificial intelligence and anesthesia research identified and summarized six themes of applications of artificial intelligence in anesthesiology: (1) depth of anesthesia monitoring, (2) control of anesthesia, (3) event and risk prediction, (4) ultrasound guidance, (5) pain management, and (6) operating room logistics. Based on papers identified in the review, several topics within artificial intelligence were described and summarized: (1) machine learning (including supervised, unsupervised, and reinforcement learning), (2) techniques in artificial intelligence (e.g., classical machine learning, neural networks and deep learning, Bayesian methods), and (3) major applied fields in artificial intelligence.The implications of artificial intelligence for the practicing anesthesiologist are discussed as are its limitations and the role of clinicians in further developing artificial intelligence for use in clinical care. Artificial intelligence has the potential to impact the practice of anesthesiology in aspects ranging from perioperative support to critical care delivery to outpatient pain management.

Figures

Fig. 1.
Fig. 1.
Preferred reporting Items for Systematic reviews and Meta-Analyses diagram of screening and evaluation process.
Fig. 2.
Fig. 2.
An illustrative example of a decision node. Several terminologies can be used to describe decision trees. The root node is the start of the tree, and branches connect nodes. A child node is any node that has been split from a previous node, whereas a decision node is any node that allows two or more options to follow it. A chance node is any node that may represent uncertainty.
Fig. 3.
Fig. 3.
An illustrative example of support vector machines. The goal of the support vector machines algorithm is to find the hyperplane that maximizes the separation of features. The solid black line represents the optimal hyperplane, whereas the dotted lines represent the planes running through the support vectors. The empty circle and the solid triangle represent support vectors—the data points from each cluster that represent the closest points to the optimal hyperplane. The dashed line represents the maximum margin between the support vectors.
Fig. 4.
Fig. 4.
An illustrative example of a three-layer neural network. The input layer provides features such as electroencephalogram (EEG) power and entropy, the patient’s mean arterial pressure (MAP), and the patient’s heart rate variability (HrV) to the network. A hidden layer transforms inputs into features usable by the network. The output layer transforms the hidden layer’s activations into an interpretable output (e.g., patient awake vs. asleep).

References

    1. Bellman R: An introduction to artificial intelligence: Can computers think? San Francisco, Boyd & Fraser Pub Co, 1978
    1. Buchanan BG: A (very) brief history of artificial intelligence. Ai Magazine 2005; 26: 53
    1. Thrall JH, Li X, Li Q, Cruz C, Do S, Dreyer K, Brink J: Artificial intelligence and machine learning in radiology: Opportunities, challenges, pitfalls, and criteria for success. J Am Coll Radiol 2018; 15(3 Pt B):504–8
    1. Salto-Tellez M, Maxwell P, Hamilton P: Artificial intelligence-the third revolution in pathology. Histopathology 2019; 74:372–6
    1. Deo RC: Machine learning in medicine. Circulation 2015; 132:1920–30
    1. Hashimoto DA, Rosman G, Rus D, Meireles OR: Artificial intelligence in surgery: Promises and perils.Ann Surg 2018; 268:70–6
    1. FDA: FDA permits marketing of artificial intelligence-based device to detect certain diabetes-related eye problems. Edited by FDA. US Food and Drug Administration, 2018
    1. Russell S, Norvig P: Artificial Intelligence: A Modern Approach, 3rd Edition Upper Saddle River, New Jersey, Prentice Hall, 2009
    1. Kendale S, Kulkarni P, Rosenberg AD, Wang J: Supervised machine-learning predictive analytics for prediction of postinduction hypotension. Anesthesiology 2018; 129:675–88
    1. Wanderer JP, Rathmell JP: Machine learning for anesthesiologists: A primer. Anesthesiology 2018; 129:A29
    1. Bisgin H, Liu Z, Fang H, Xu X, Tong W: Mining FDA drug labels using an unsupervised learning technique–topic modeling. BMC Bioinformatics 2011; 12 Suppl 10:S11
    1. Hakonarson H, Bjornsdottir US, Halapi E, Bradfield J, Zink F, Mouy M, Helgadottir H, Gudmundsdottir AS, Andrason H, Adalsteinsdottir AE, Kristjansson K, Birkisson I, Arnason T, Andresdottir M, Gislason D, Gislason T, Gulcher JR, Stefansson K: Profiling of genes expressed in peripheral blood mononuclear cells predicts glucocorticoid sensitivity in asthma patients. Proc Natl Acad Sci U S A 2005; 102:14789–94
    1. Sutton RS, Barto AG: Reinforcement Learning: An Introduction, MIT press Cambridge, 1998
    1. Padmanabhan R, Meskin N, Haddad WM: Closed-loop control of anesthesia and mean arterial pressure using reinforcement learning. Biomed Signal Process Control 2015; 22: 54–64
    1. Ng A: Supervised Learning, CS229 Lecture Notes. Edited by Ng A, Stanford University, 2018
    1. Zadeh LA: Fuzzy sets. Information and Control 1965; 8: 338–353
    1. Baig MM, Gholamhosseini H, Kouzani A, Harrison MJ: Anaesthesia monitoring using fuzzy logic. J Clin Monit Comput 2011; 25:339–47
    1. Hu YJ, Ku TH, Jan RH, Wang K, Tseng YC, Yang SF: Decision tree-based learning to predict patient controlled analgesia consumption and readjustment. BMC Med Inform Decis Mak 2012; 12:131.
    1. Hastie T, Tibshirani R, Friedman J: Overview of Supervised Learning, The Elements of Statistical Learning: Data Mining, Inference, and Prediction. New York, Springer, 2016, pp 9–42
    1. Hastie T, Tibshirani R, Friedman J: Support Vector Machines and Flexible Discriminants, The Elements of Statistical Learning: Data Mining, Inference, and Prediction. New York, Springer, 2016, pp 417–58
    1. McCulloch WS, Pitts W: A logical calculus of the ideas immanent in nervous activity. Bulletin of Mathematical Biophysics 1943; 5: 115–33
    1. LeCun Y, Bengio Y, Hinton G: Deep learning. Nature 2015; 521:436–44
    1. Bland JM, Altman DG: Bayesians and frequentists. BMJ 1998; 317:1151–60
    1. Ghahramani Z: Probabilistic machine learning and artificial intelligence. Nature 2015; 521:452–9
    1. Kirkos E, Spathis C, Manolopoulos Y: Data mining techniques for the detection of fraudulent financial statements. Expert Syst Appl 2007; 32: 995–1003
    1. van den Berg JP, Eleveld DJ, De Smet T, van den Heerik AVM, van Amsterdam K, Lichtenbelt BJ, Scheeren TWL, Absalom AR, Struys MMRF: Influence of Bayesian optimization on the performance of propofol target-controlled infusion. Br J Anaesth 2017; 119:918–27
    1. Kukacka M: Bayesian Methods in Artificial Intelligence, WDS’10 Proceedings of Contributed Papers, 2010, pp 25–30
    1. Nadkarni PM, Ohno-Machado L, Chapman WW: Natural language processing: An introduction. J Am Med Inform Assoc 2011; 18:544–51
    1. Murff HJ, FitzHenry F, Matheny ME, Gentry N, Kotter KL, Crimin K, Dittus RS, Rosen AK, Elkin PL, Brown SH, Speroff T: Automated identification of postoperative complications within an electronic medical record using natural language processing. JAMA 2011; 306:848–55
    1. Cohen KB, Glass B, Greiner HM, Holland-Bouley K, Standridge S, Arya R, Faist R, Morita D, Mangano F, Connolly B, Glauser T, Pestian J: Methodological issues in predicting pediatric epilepsy surgery candidates through natural language processing and machine learning. Biomed Inform Insights 2016; 8:11–8
    1. Friedman C, Shagina L, Lussier Y, Hripcsak G: Automated encoding of clinical documents based on natural language processing. J Am Med Inform Assoc 2004; 11:392–402
    1. Ehteshami Bejnordi B, Veta M, Johannes van Diest P, van Ginneken B, Karssemeijer N, Litjens G, van der Laak JAWM, Hermsen M, Manson QF, Balkenhol M, Geessink O, Stathonikos N, van Dijk MC, Bult P, Beca F, Beck AH, Wang D, Khosla A, Gargeya R, Irshad H, Zhong A, Dou Q, Li Q, Chen H, Lin HJ, Heng PA, Haß C, Bruni E, Wong Q, Halici U, Öner MÜ, Cetin-Atalay R, Berseth M, Khvatkov V, Vylegzhanin A, Kraus O, Shaban M, Rajpoot N, Awan R, Sirinukunwattana K, Qaiser T, Tsang YW, Tellez D, Annuscheit J, Hufnagl P, Valkonen M, Kartasalo K, Latonen L, Ruusuvuori P, Liimatainen K, Albarqouni S, Mungal B, George A, Demirci S, Navab N, Watanabe S, Seno S, Takenaka Y, Matsuda H, Ahmady Phoulady H, Kovalev V, Kalinovsky A, Liauchuk V, Bueno G, Fernandez-Carrobles MM, Serrano I, Deniz O, Racoceanu D, Venâncio R; the CAMELYON16 Consortium: Diagnostic assessment of deep learning algorithms for detection of lymph node metastases in women with breast cancer. JAMA 2017; 318:2199–210
    1. Tajmir SH, Lee H, Shailam R, Gale HI, Nguyen JC, Westra SJ, Lim R, Yune S, Gee MS, Do S: Artificial intelligence-assisted interpretation of bone age radiographs improves accuracy and decreases variability. Skeletal Radiol 2019; 48:275–83
    1. Volkov M, Hashimoto DA, Rosman G, Meireles OR, Rus D: Machine learning and coresets for automated real-time video segmentation of laparoscopic and robot-assisted surgery, IEEE International Conference on Robotics and Automation (ICRA), 2017, pp 754–9
    1. Pesteie M, Lessoway V, Abolmaesumi P, Rohling RN: Automatic localization of the needle target for ultrasound-guided epidural injections. IEEE Trans Med Imaging 2018; 37:81–92
    1. Smistad E, Lovstakken L, Carneiro G, Mateus D, Peter L, Bradley A, Tavares J, Belagiannis V, Papa JP, Nascimento JC, Loog M, Lu Z, Cardoso JS, Cornebise J: Vessel Detection in Ultrasound Images Using Deep Convolutional Neural Networks, Med Image Comput Comput Assist Inter, Springer, 2016, pp 30–8
    1. Fritz BA, Maybrier HR, Avidan MS: Intraoperative electroencephalogram suppression at lower volatile anaesthetic concentrations predicts postoperative delirium occurring in the intensive care unit. Br J Anaesth 2018; 121:241–8
    1. Kertai MD, Pal N, Palanca BJ, Lin N, Searleman SA, Zhang L, Burnside BA, Finkel KJ, Avidan MS; B-Unaware Study Group: Association of perioperative risk factors and cumulative duration of low bispectral index with intermediate-term mortality after cardiac surgery in the B-Unaware Trial. Anesthesiology 2010; 112:1116–27
    1. Sessler DI, Sigl JC, Kelley SD, Chamoun NG, Manberg PJ, Saager L, Kurz A, Greenwald S: Hospital stay and mortality are increased in patients having a “triple low” of low blood pressure, low bispectral index, and low minimum alveolar concentration of volatile anesthesia. Anesthesiology 2012; 116:1195–203
    1. Veselis RA, Reinsel R, Sommer S, Carlon G: Use of neural network analysis to classify electroencephalographic patterns against depth of midazolam sedation in intensive care unit patients. J Clin Monit 1991; 7:259–67
    1. Veselis RA, Reinsel R, Wronski M: Analytical methods to differentiate similar electroencephalographic spectra: neural network and discriminant analysis. J Clin Monit 1993; 9:257–67
    1. Ortolani O, Conti A, Di Filippo A, Adembri C, Moraldi E, Evangelisti A, Maggini M, Roberts SJ: EEG signal processing in anaesthesia: Use of a neural network technique for monitoring depth of anaesthesia. Br J Anaesth 2002; 88:644–8
    1. Benzy VK, Jasmin EA, Koshy RC, Amal F: Wavelet Entropy based classification of depth of anesthesia. 2016 International Conference on Computational Techniques in Information and Communication Technologies (ICCTICT) 2016: 521–4
    1. Mirsadeghi M, Behnam H, Shalbaf R, Jelveh Moghadam H: Characterizing awake and anesthetized states using a dimensionality reduction method. J Med Syst 2016; 40:13.
    1. Shalbaf A, Saffar M, Sleigh JW, Shalbaf R: Monitoring the depth of anesthesia using a new adaptive neuro-fuzzy system. IEEE J Biomed Health Inform 2018; 22:671–7
    1. Nagaraj SB, Biswal S, Boyle EJ, Zhou DW, McClain LM, Bajwa EK, Quraishi SA, Akeju O, Barbieri R, Purdon PL, Westover MB: Patient-specific classification of ICU sedation levels from heart rate variability. Crit Care Med 2017; 45:e683–90
    1. Ranta SO, Hynynen M, Räsänen J: Application of artificial neural networks as an indicator of awareness with recall during general anaesthesia. J Clin Monit Comput 2002; 17:53–60
    1. Dumont GA, Ansermino JM: Closed-loop control of anesthesia: A primer for anesthesiologists. Anesth Analg 2013; 117:1130–8
    1. Tsutsui T, Arita S: Fuzzy-logic control of blood pressure through enflurane anesthesia. J Clin Monit 1994; 10:110–7
    1. Zbinden AM, Feigenwinter P, Petersen-Felix S, Hacisalihzade S: Arterial pressure control with isoflurane using fuzzy logic. Br J Anaesth 1995; 74:66–72
    1. Absalom AR, Sutcliffe N, Kenny GN: Closed-loop control of anesthesia using Bispectral index: Performance assessment in patients undergoing major orthopedic surgery under combined general and regional anesthesia. Anesthesiology 2002; 96:67–73
    1. Shieh JS, Kao MH, Liu CC: Genetic fuzzy modelling and control of bispectral index (BIS) for general intravenous anaesthesia. Med Eng Phys 2006; 28:134–48
    1. Lowery C, Faisal AA: Towards efficient, personalized anesthesia using continuous reinforcement learning for propofol infusion control. 2013 6th International IEEE/EMBS Conference on Neural Engineering (NER) 2013: 1414–7
    1. Zaouter C, Hemmerling TM, Lanchon R, Valoti E, Remy A, Leuillet S, Ouattara A: The feasibility of a completely automated total IV anesthesia drug delivery system for cardiac surgery. Anesth Analg 2016; 123:885–93
    1. Lendl M, Schwarz UH, Romeiser HJ, Unbehauen R, Georgieff M, Geldner GF: Nonlinear model-based predictive control of non-depolarizing muscle relaxants using neural networks. J Clin Monit Comput 1999; 15:271–8
    1. Shieh JS, Fan SZ, Chang LW, Liu CC: Hierarchical rule-based monitoring and fuzzy logic control for neuromuscular block. J Clin Monit Comput 2000; 16:583–92
    1. Motamed C, Devys JM, Debaene B, Billard V: Influence of real-time Bayesian forecasting of pharmacokinetic parameters on the precision of a rocuronium target-controlled infusion. Eur J Clin Pharmacol 2012; 68:1025–31
    1. Martinoni EP, Pfister ChA, Stadler KS, Schumacher PM, Leibundgut D, Bouillon T, Böhlen T, Zbinden AM: Model-based control of mechanical ventilation: Design and clinical validation. Br J Anaesth 2004; 92:800–7
    1. Schäublin J, Derighetti M, Feigenwinter P, Petersen-Felix S, Zbinden AM: Fuzzy logic control of mechanical ventilation during anaesthesia. Br J Anaesth 1996; 77:636–41
    1. Schädler D, Mersmann S, Frerichs I, Elke G, Semmel-Griebeler T, Noll O, Pulletz S, Zick G, David M, Heinrichs W, Scholz J, Weiler N: A knowledge- and model-based system for automated weaning from mechanical ventilation: Technical description and first clinical application. J Clin Monit Comput 2014; 28:487–98
    1. Lin CS, Li YC, Mok MS, Wu CC, Chiu HW, Lin YH: Neural network modeling to predict the hypnotic effect of propofol bolus induction. Proc AMIA Symp 2002: 450–3
    1. Nunes CS, Mendonca TF, Amorim P, Ferreira DA, Antunes L: Comparison of neural networks, fuzzy and stochastic prediction models for return of consciousness after general anesthesia. Proceedings of the 44th IEEE Conference on Decision and Control 2005: 4827–32
    1. Santanen OA, Svartling N, Haasio J, Paloheimo MP: Neural nets and prediction of the recovery rate from neuromuscular block. Eur J Anaesthesiol 2003; 20:87–92
    1. Lin CS, Chang CC, Chiu JS, Lee YW, Lin JA, Mok MS, Chiu HW, Li YC: Application of an artificial neural network to predict postinduction hypotension during general anesthesia. Med Decis Making 2011; 31:308–14
    1. Lin CS, Chiu JS, Hsieh MH, Mok MS, Li YC, Chiu HW: Predicting hypotensive episodes during spinal anesthesia with the application of artificial neural networks. Comput Methods Programs Biomed 2008; 92:193–7
    1. Zhang L, Fabbri D, Lasko TA, Ehrenfeld JM, Wanderer JP: A system for automated determination of perioperative patient acuity. J Med Syst 2018; 42:123.
    1. Moustafa MA, El-Metainy S, Mahar K, Mahmoud Abdel-magied E: Defining difficult laryngoscopy findings by using multiple parameters: A machine learning approach. Egypt J Anaesth 2017; 33: 153–8
    1. Berkenstadt H, Ben-Menachem E, Herman A, Dach R: An evaluation of the Integrated Pulmonary Index (IPI) for the detection of respiratory events in sedated patients undergoing colonoscopy. J Clin Monit Comput 2012; 26:177–81
    1. Hancerliogullari G, Hancerliogullari KO, Koksalmis E: The use of multi-criteria decision making models in evaluating anesthesia method options in circumcision surgery. BMC Med Inform Decis Mak 2017; 17:14.
    1. Hatib F, Jian Z, Buddi S, Lee C, Settels J, Sibert K, Rinehart J, Cannesson M: Machine-learning algorithm to predict hypotension based on high-fidelity arterial pressure waveform analysis. Anesthesiology 2018; 129:663–74
    1. Gao L, Smielewski P, Czosnyka M, Ercole A: Cerebrovascular signal complexity six hours after intensive care unit admission correlates with outcome after severe traumatic brain injury. J Neurotrauma 2016; 33:2011–8
    1. Gao L, Smielewski P, Czosnyka M, Ercole A: Early asymmetric cardio-cerebral causality and outcome after severe traumatic brain injury. J Neurotrauma 2017; 34:2743–52
    1. Gottschalk A, Hyzer MC, Geer RT: A comparison of human and machine-based predictions of successful weaning from mechanical ventilation. Med Decis Making 2000; 20:160–9
    1. Bonds BW, Yang S, Hu PF, Kalpakis K, Stansbury LG, Scalea TM, Stein DM: Predicting secondary insults after severe traumatic brain injury. J Trauma Acute Care Surg 2015; 79:85–90; discussion 90
    1. Jalali A, Bender D, Rehman M, Nadkanri V, Nataraj C: Advanced analytics for outcome prediction in intensive care units. 2016 38th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC) 2016: 2520–4
    1. Clermont G, Angus DC, DiRusso SM, Griffin M, Linde-Zwirble WT: Predicting hospital mortality for patients in the intensive care unit: A comparison of artificial neural networks with logistic regression models. Crit Care Med 2001; 29:291–6
    1. Desautels T, Das R, Calvert J, Trivedi M, Summers C, Wales DJ, Ercole A: Prediction of early unplanned intensive care unit readmission in a UK tertiary care hospital: A cross-sectional machine learning approach. BMJ Open 2017; 7:e017199
    1. Desautels T, Calvert J, Hoffman J, Jay M, Kerem Y, Shieh L, Shimabukuro D, Chettipally U, Feldman MD, Barton C, Wales DJ, Das R: Prediction of sepsis in the intensive care unit with minimal electronic health record data: A machine learning approach. JMIR Med Inform 2016; 4:e28.
    1. Shimabukuro DW, Barton CW, Feldman MD, Mataraso SJ, Das R: Effect of a machine learning-based severe sepsis prediction algorithm on patient survival and hospital length of stay: A randomised clinical trial. BMJ Open Respir Res 2017; 4:e000234
    1. Hetherington J, Lessoway V, Gunka V, Abolmaesumi P, Rohling R: SLIDE: Automatic spine level identification system using a deep convolutional neural network. Int J Comput Assist Radiol Surg 2017; 12:1189–98
    1. Olesen AE, Grønlund D, Gram M, Skorpen F, Drewes AM, Klepstad P: Prediction of opioid dose in cancer pain patients using genetic profiling: Not yet an option with support vector machine learning. BMC Res Notes 2018; 11:78.
    1. Tighe PJ, Lucas SD, Edwards DA, Boezaart AP, Aytug H, Bihorac A: Use of machine-learning classifiers to predict requests for preoperative acute pain service consultation. Pain Med 2012; 13:1347–57
    1. Gonzalez-Cava JM, Arnay R, Perez JAM, Leon A, Martin M, Jove-Perez E, Calvo-Rolle JL, CasteleiroRoca JL, Juez FJD, Garcia HP, AlfonsoCendon J, Gonzalez LS, Quintian H, Corchado E: A Machine learning based system for analgesic drug delivery. International joint Conference SOCO’17-CISIS’17-ICEUTE’17 2017; 649: 461–70
    1. Ben-Israel N, Kliger M, Zuckerman G, Katz Y, Edry R: Monitoring the nociception level: A multi-parameter approach. J Clin Monit Comput 2013; 27:659–68
    1. Gram M, Erlenwein J, Petzke F, Falla D, Przemeck M, Emons MI, Reuster M, Olesen SS, Drewes AM: Prediction of postoperative opioid analgesia using clinical-experimental parameters and electroencephalography. Eur J Pain 2017; 21:264–77
    1. Combes C, Meskens N, Rivat C, Vandamme JP: Using a KDD process to forecast the duration of surgery. Int J Prod Econ 2008; 112: 279–93
    1. Devi SP, Rao KS, Sangeetha SS: Prediction of surgery times and scheduling of operation theaters in ophthalmology department. J Med Syst 2012; 36:415–30
    1. Houliston BR, Parry DT, Merry AF: TADAA: Towards automated detection of anaesthetic activity. Methods Inf Med 2011; 50:464–71
    1. Silver D, Hubert T, Schrittwieser J, Antonoglou I, Lai M, Guez A, Lanctot M, Sifre L, Kumaran D, Graepel T, Lillicrap T, Simonyan K, Hassabis D: A general reinforcement learning algorithm that masters chess, shogi, and Go through self-play. Science 2018; 362:1140–4
    1. Walraet M, Tromp J: A Googolplex of Go Games. Cham, Springer International Publishing, 2016, pp 191–201
    1. Proposed Regulatory Framework for Modifications to Artificial Intelligence/Machine Learning (AI/ML)-Based Software as a Medical Device (SaMD) - Discussion Paper and Request for Feedback, Food and Drug Administration, 2019, pp 1–20
    1. Liem VGB, Hoeks SE, van Lier F, de Graaff JC: What we can learn from Big Data about factors influencing perioperative outcome. Curr Opin Anaesthesiol 2018; 31:723–31
    1. Sciusco A, Standing JF, Sheng Y, Raimondo P, Cinnella G, Dambrosio M: Effect of age on the performance of bispectral and entropy indices during sevoflurane pediatric anesthesia: A pharmacometric study. Paediatr Anaesth 2017; 27:399–408
    1. Olofsen E, Sleigh JW, Dahan A: Permutation entropy of the electroencephalogram: A measure of anaesthetic drug effect. Br J Anaesth 2008; 101:810–21
    1. Eagleman SL, Drover DR: Calculations of consciousness: electroencephalography analyses to determine anesthetic depth. Curr Opin Anaesthesiol 2018; 31:431–8
    1. Ghassemi M, Celi LA, Stone DJ: State of the art review: The data revolution in critical care. Crit Care 2015; 19:118.
    1. Avidan MS, Jacobsohn E, Glick D, Burnside BA, Zhang L, Villafranca A, Karl L, Kamal S, Torres B, O’Connor M, Evers AS, Gradwohl S, Lin N, Palanca BJ, Mashour GA; BAG-RECALL Research Group: Prevention of intraoperative awareness in a high-risk surgical population. N Engl J Med 2011; 365:591–600
    1. Avidan MS, Zhang L, Burnside BA, Finkel KJ, Searleman AC, Selvidge JA, Saager L, Turner MS, Rao S, Bottros M, Hantler C, Jacobsohn E, Evers AS: Anesthesia awareness and the bispectral index. N Engl J Med 2008; 358:1097–108
    1. Gambus P, Shafer SL: Artificial intelligence for everyone. Anesthesiology 2018; 128:431–3
    1. Sicular S, Brant K: Hype Cycle for Artificial Intelligence, 2018. Edited by Gartner I. Gartner, 2018, pp 1–73
    1. Lee H, Tajmir S, Lee J, Zissen M, Yeshiwas BA, Alkasab TK, Choy G, Do S: Fully automated deep learning system for bone age assessment. J Digit Imaging 2017; 30:427–41
    1. Murthy VH, Krumholz HM, Gross CP: Participation in cancer clinical trials: Race-, sex-, and age-based disparities. JAMA 2004; 291:2720–6
    1. Schulman KA, Berlin JA, Harless W, Kerner JF, Sistrunk S, Gersh BJ, Dubé R, Taleghani CK, Burke JE, Williams S, Eisenberg JM, Escarce JJ: The effect of race and sex on physicians’ recommendations for cardiac catheterization. N Engl J Med 1999; 340:618–26
    1. Char DS, Shah NH, Magnus D: Implementing machine learning in health care - Addressing ETHICAL CHALLENGES. N Engl J Med 2018; 378:981–3
    1. Weber GM, Mandl KD, Kohane IS: Finding the missing link for big biomedical data. JAMA 2014; 311:2479–800

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