Chrononutrition in the management of diabetes

Christiani Jeyakumar Henry, Bhupinder Kaur, Rina Yu Chin Quek, Christiani Jeyakumar Henry, Bhupinder Kaur, Rina Yu Chin Quek

Abstract

Circadian rhythms are 24-h cycles regulated by endogeneous molecular oscillators called the circadian clock. The effects of diet on circadian rhythmicity clearly involves a relationship between factors such as meal timings and nutrients, known as chrononutrition. Chrononutrition is influenced by an individual's "chronotype", whereby "evening chronotypes" or also termed "later chronotype" who are biologically driven to consume foods later in the day. Research in this area has suggested that time of day is indicative of having an influence on the postprandial glucose response to a meal, therefore having a major effect on type 2 diabetes. Cross-sectional and experimental studies have shown the benefits of consuming meals early in the day than in the evening on postprandial glycaemia. Modifying the macronutrient composition of night meals, by increasing protein and fat content, has shown to be a simple strategy to improve postprandial glycaemia. Low glycaemic index (GI) foods eaten in the morning improves glycaemic response to a greater effect than when consumed at night. Timing of fat and protein (including amino acids) co-ingested with carbohydrate foods, such as bread and rice, can reduce glycaemic response. The order of food presentation also has considerable potential in reducing postprandial blood glucose (consuming vegetables first, followed by meat and then lastly rice). These practical recommendations could be considered as strategies to improve glycaemic control, rather than focusing on the nutritional value of a meal alone, to optimize dietary patterns of diabetics. It is necessary to further elucidate this fascinating area of research to understand the circadian system and its implications on nutrition that may ultimately reduce the burden of type 2 diabetes.

Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1. A schematic representation outlining the…
Fig. 1. A schematic representation outlining the factors affecting the circadian clock system.
Meal timing and dietary components (chrononutrition) play an important role in regulating circadian clocks, to enhance metabolic health and reduce the risk of type 2 diabetes.

References

    1. Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat. Rev. Endocrinol. 2017;14:88.
    1. Herman, W. H. in Diabetes Mellitus in Developing Countries and Underserved Communities (ed. Dagogo-Jack, S.) 1–5 (Springer International Publishing, Cham, 2017).
    1. Kurose T, Hyo T, Yabe D, Seino Y. The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes. Chronophysiology Ther. 2014;4:41–49.
    1. Albrecht U, Eichele G. The mammalian circadian clock. Curr. Opin. Genet. Dev. 2003;13:271–277.
    1. Huang W, Ramsey KM, Marcheva B, Bass J. Circadian rhythms, sleep, and metabolism. J. Clin. Investig. 2011;121:2133–2141.
    1. Ibata Y, et al. Functional morphology of the suprachiasmatic nucleus. Front. Neuroendocrinol. 1999;20:241–268.
    1. Johnston JD. Physiological responses to food intake throughout the day. Nutr. Res. Rev. 2014;27:107–118.
    1. Oike H, Oishi K, Kobori M. Nutrients, clock genes, and chrononutrition. Curr. Nutr. Rep. 2014;3:204–212.
    1. Almoosawi S, et al. Chronotype: implications for epidemiologic studies on chrono-nutrition and cardiometabolic health. Adv. Nutr. 2018;10:30–42.
    1. Wong PM, Hasler BP, Kamarck TW, Muldoon MF, Manuck SB. Social jetlag, chronotype, and cardiometabolic risk. J. Clin. Endocrinol. Metab. 2015;100:4612–4620.
    1. Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc. Natl Acad. Sci. USA. 2009;106:4453–4458.
    1. Qian J, Scheer FA. Circadian system and glucose metabolism: implications for physiology and disease. Trends Endocrinol. Metab. 2016;27:282–293.
    1. Kalsbeek A, la Fleur S, Fliers E. Circadian control of glucose metabolism. Mol. Metab. 2014;3:372–383.
    1. Froy O. The relationship between nutrition and circadian rhythms in mammals. Front. Neuroendocrinol. 2007;28:61–71.
    1. Czeisler CA, Klerman EB. Circadian and sleep-dependent regulation of hormone release in humans. Recent Prog. Horm. Res. 1999;54:97–130.
    1. Marcheva B, et al. Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes. Nature. 2010;466:627.
    1. Gale JE, et al. Disruption of circadian rhythms accelerates development of diabetes through pancreatic beta-cell loss and dysfunction. J. Biol. Rhythms. 2011;26:423–433.
    1. Shi S-Q, Ansari TS, McGuinness OP, Wasserman DH, Johnson CH. Circadian disruption leads to insulin resistance and obesity. Curr. Biol. 2013;23:372–381.
    1. Bandin C, et al. Meal timing affects glucose tolerance, substrate oxidation and circadian-related variables: a randomized, crossover trial. Int. J. Obes. 2015;39:828.
    1. Wehrens SMT, et al. Meal timing regulates the human circadian system. Curr. Biol. 2017;27:1768–75.e3.
    1. Gill S, Panda S. A smartphone app reveals erratic diurnal eating patterns in humans that can be modulated for health benefits. Cell Metab. 2015;22:789–798.
    1. Antunes L, Levandovski R, Dantas G, Caumo W, Hidalgo M. Obesity and shift work: chronobiological aspects. Nutr. Res. Rev. 2010;23:155–168.
    1. Morikawa Y, et al. Effect of shift work on body mass index and metabolic parameters. Scand. J. Work, Environ. Health. 2007;33:45–50.
    1. Zimberg IZ, Fernandes Junior SA, Crispim CA, Tufik S, de Mello MT. Metabolic impact of shift work. Work. 2012;41(Suppl 1):4376–4383.
    1. Ribeiro D, Hampton S, Morgan L. Altered postprandial hormone and metabolic responses in a simulated shift work environment. Occup. Health Ind. Med. 1999;1:40–41.
    1. Lund J, Arendt J, Hampton S, English J, Morgan L. Postprandial hormone and metabolic responses amongst shift workers in Antarctica. J. Endocrinol. 2001;171:557–564.
    1. Hampton S, et al. Postprandial hormone and metabolic responses in simulated shift work. J. Endocrinol. 1996;151:259–267.
    1. Nagaya T, Yoshida H, Takahashi H, Kawai M. Markers of insulin resistance in day and shift workers aged 30–59 years. Int. Arch. Occup. Environ. Health. 2002;75:562–568.
    1. Whitehead DC, Thomas H, Jr., Slapper DR. A rational approach to shift work in emergency medicine. Ann. Emerg. Med. 1992;21:1250–1258.
    1. Knutsson A. Health disorders of shift workers. Occup. Med. 2003;53:103–108.
    1. Reutrakul S, et al. The relationship between breakfast skipping, chronotype, and glycemic control in type 2 diabetes. Chronobiol. Int. 2014;31:64–71.
    1. Mekary RA, Giovannucci E, Willett WC, van Dam RM, Hu FB. Eating patterns and type 2 diabetes risk in men: breakfast omission, eating frequency, and snacking. Am. J. Clin. Nutr. 2012;95:1182–1189.
    1. Farshchi HR, Taylor MA, Macdonald IA. Deleterious effects of omitting breakfast on insulin sensitivity and fasting lipid profiles in healthy lean women. Am. J. Clin. Nutr. 2005;81:388–396.
    1. Meule A, Roeser K, Randler C, Kübler A. Skipping breakfast: morningness-eveningness preference is differentially related to state and trait food cravings. Eat. Weight Disord.-Stud. Anorex., Bulim. Obes. 2012;17:e304–e308.
    1. Nakajima K, Suwa K. Association of hyperglycemia in a general Japanese population with late-night-dinner eating alone, but not breakfast skipping alone. J. Diabetes Metab. Disord. 2015;14:16.
    1. Kobayashi F, et al. Effect of breakfast skipping on diurnal variation of energy metabolism and blood glucose. Obes. Res. Clin. Pract. 2014;8:e249–e57.
    1. Sakai R, et al. Late-night-dinner is associated with poor glycemic control in people with type 2 diabetes: The KAMOGAWA-DM cohort study. Endocr. J. 2018;65:395–402.
    1. Silva CM, et al. Chronotype, social jetlag and sleep debt are associated with dietary intake among Brazilian undergraduate students. Chronobiol. Int. 2016;33:740–748.
    1. Zilberter T, Zilberter EY. Breakfast: to skip or not to skip? Front Public Health. 2014;2:59.
    1. Van Lippevelde W, et al. Associations between family-related factors, breakfast consumption and BMI among 10-to 12-year-old European children: the cross-sectional ENERGY-study. PLoS ONE. 2013;8:e79550.
    1. Timlin MT, Pereira MA, Story M, Neumark-Sztainer D. Breakfast eating and weight change in a 5-year prospective analysis of adolescents: project EAT (eating among teens) Pediatrics. 2008;121:e638–e645.
    1. Willcox BJ, et al. Caloric restriction, caloric restriction mimetics, and healthy aging in Okinawa. Ann. N. Y. Acad. Sci. 2007;1114:434–455.
    1. Dutton SB, et al. Protective effect of the ketogenic diet in Scn1a mutant mice. Epilepsia. 2011;52:2050–2056.
    1. Malherbe C, de Gasparo M, de Hertogh R, Hoem JJ. Circadian variations of blood sugar and plasma insulin levels in man. Diabetologia. 1969;5:397–404.
    1. Service FJ, et al. Effects of size, time of day and sequence of meal ingestion on carbohydrate tolerance in normal subjects. Diabetologia. 1983;25:316–321.
    1. Van Cauter E, Shapiro ET, Tillil H, Polonsky KS. Circadian modulation of glucose and insulin responses to meals: relationship to cortisol rhythm. Am. J. Physiol.-Endocrinol. Metab. 1992;262:E467–E475.
    1. Cauter EV, Desir D, Decoster C, Fery F, Balasse EO. Nocturnal decrease in glucose tolerance during constant glucose infusion. J. Clin. Endocrinol. Metab. 1989;69:604–611.
    1. Sato M, et al. Acute effect of late evening meal on diurnal variation of blood glucose and energy metabolism. Obes. Res. Clin. Pract. 2011;5:e220–e8.
    1. Kajiyama S, et al. Divided consumption of late-night-dinner improves glucose excursions in young healthy women: a randomized cross-over clinical trial. Diabetes Res. Clin. Pract. 2018;136:78–84.
    1. Al-Naimi S, Hampton SM, Richard P, Tzung C, Morgan LM. Postprandial metabolic profiles following meals and snacks eaten during simulated night and day shift work. Chronobiol. Int. 2004;21:937–947.
    1. Imai S, et al. Divided consumption of late-night-dinner improves glycemic excursions in patients with type 2 diabetes: a randomized cross-over clinical trial. Diabetes Res. Clin. Pract. 2017;129:206–212.
    1. Peter R, et al. Daytime variability of postprandial glucose tolerance and pancreatic B‐cell function using 12‐h profiles in persons with type 2 diabetes. Diabet. Med. 2010;27:266–273.
    1. Jakubowicz D, et al. Fasting until noon triggers increased postprandial hyperglycemia and impaired insulin response after lunch and dinner in individuals with type 2 diabetes: a randomized clinical trial. Diabetes Care. 2015;38:1820–1826.
    1. Fuse Y, et al. Differential roles of breakfast only (one meal per day) and a bigger breakfast with a small dinner (two meals per day) in mice fed a high-fat diet with regard to induced obesity and lipid metabolism. J. Circadian Rhythms. 2012;10:4.
    1. Wu T, et al. Differential roles of breakfast and supper in rats of a daily three-meal schedule upon circadian regulation and physiology. Chronobiol. Int. 2011;28:890–903.
    1. Bo S, et al. Consuming more of daily caloric intake at dinner predisposes to obesity. A 6-year population-based prospective cohort study. PLoS ONE. 2014;9:e108467.
    1. Jakubowicz D, Barnea M, Wainstein J, Froy O. High Caloric intake at breakfast vs. dinner differentially influences weight loss of overweight and obese women. Obesity. 2013;21:2504–2512.
    1. Jakubowicz D, et al. High-energy breakfast with low-energy dinner decreases overall daily hyperglycaemia in type 2 diabetic patients: a randomised clinical trial. Diabetologia. 2015;58:912–919.
    1. Thomas T, Pfeiffer AFH. Foods for the prevention of diabetes: how do they work? Diabetes/Metab. Res. Rev. 2012;28:25–49.
    1. Wolever TMS. Dietary carbohydrates and insulin action in humans. Br. J. Nutr. 2007;83(S1):S97–S102.
    1. Almoosawi S, Prynne C, Hardy R, Stephen A. Time-of-day and nutrient composition of eating occasions: prospective association with the metabolic syndrome in the 1946 British birth cohort. Int. J. Obes. 2013;37:725.
    1. Almoosawi S, Prynne C, Hardy R, Stephen A. Diurnal eating rhythms: association with long-term development of diabetes in the 1946 British birth cohort. Nutr., Metab. Cardiovascular Dis. 2013;23:1025–1030.
    1. Kessler K, et al. The effect of diurnal distribution of carbohydrates and fat on glycaemic control in humans: a randomized controlled trial. Sci. Rep. 2017;7:44170.
    1. Tsuchida Y, Hata S, Sone Y. Effects of a late supper on digestion and the absorption of dietary carbohydrates in the following morning. J. Physiological Anthropol. 2013;32:9.
    1. Jenkins DJ, et al. Glycemic index of foods: a physiological basis for carbohydrate exchange. Am. J. Clin. Nutr. 1981;34:362–366.
    1. Ludwig DS. The glycemic index: physiological mechanisms relating to obesity, diabetes, and cardiovascular disease. JAMA. 2002;287:2414–2423.
    1. Kaur B, Ranawana V, Teh A-L, Henry CJK. The impact of a low glycemic index (GI) breakfast and snack on daily blood glucose profiles and food intake in young Chinese adult males. J. Clin. Transl. Endocrinol. 2015;2:92–98.
    1. Morgan LM, Shi J-W, Hampton SM, Frost G. Effect of meal timing and glycaemic index on glucose control and insulin secretion in healthy volunteers. Br. J. Nutr. 2012;108:1286–1291.
    1. Gibbs M, Harrington D, Starkey S, Williams P, Hampton S. Diurnal postprandial responses to low and high glycaemic index mixed meals. Clin. Nutr. 2014;33:889–894.
    1. Carrasco-Benso MP, et al. Human adipose tissue expresses intrinsic circadian rhythm in insulin sensitivity. FASEB J. 2016;30:3117–3123.
    1. Gamble KL, Berry R, Frank SJ, Young ME. Circadian clock control of endocrine factors. Nat. Rev. Endocrinol. 2014;10:466–475.
    1. Leung GKW, Huggins CE, Bonham MP. Effect of meal timing on postprandial glucose responses to a low glycemic index meal: a crossover trial in healthy volunteers. Clin. Nutr. 2019;38:465–471.
    1. Morris CJ, et al. Endogenous circadian system and circadian misalignment impact glucose tolerance via separate mechanisms in humans. Proc. Natl Acad. Sci USA. 2015;112:E2225–E2234.
    1. Holmbäck U, et al. Metabolic responses to nocturnal eating in men are affected by sources of dietary energy. J. Nutr. 2002;132:1892–1899.
    1. Bonham MP, et al. Effects of macronutrient manipulation on postprandial metabolic responses in overweight males with high fasting lipids during simulated shift work: a randomized crossover trial. Clin. Nutr. 2019;39:369–377.
    1. Davis, R., Bonham, M. P., Nguo, K. & Huggins, C. E. Glycaemic response at night is improved after eating a high protein meal compared with a standard meal: a cross-over study. Clin. Nutr. (2019). 10.1016/j.clnu.2019.06.014 (in press).
    1. Gentilcore D, et al. Effects of fat on gastric emptying of and the glycemic, insulin, and incretin responses to a carbohydrate meal in type 2 diabetes. J. Clin. Endocrinol. Metab. 2006;91:2062–2067.
    1. Sun L, Tan KWJ, Han CMS, Leow MK-S, Henry CJ. Impact of preloading either dairy or soy milk on postprandial glycemia, insulinemia and gastric emptying in healthy adults. Eur. J. Nutr. 2017;56:77–87.
    1. Sun L, Wei Jie Tan K, Jeyakumar Henry C. Co-ingestion of essence of chicken to moderate glycaemic response of bread. Int. J. Food Sci. Nutr. 2015;66:931–935.
    1. Soong YY, Lim J, Sun L, Henry CJ. Effect of co-ingestion of amino acids with rice on glycaemic and insulinaemic response. Br. J. Nutr. 2015;114:1845–1851.
    1. Sun, L., Goh, H. J., Govindharajulu, P., Leow, M. K.-S. & Henry, C. J. Postprandial glucose, insulin and incretin responses differ by test meal macronutrient ingestion sequence (PATTERN study). Clin. Nutr. (2019). 10.1016/j.clnu.2019.04.001 (in press).
    1. Zheng X-X, et al. Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials. Am. J. Clin. Nutr. 2013;97:750–762.
    1. Venables MC, Hulston CJ, Cox HR, Jeukendrup AE. Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans. Am. J. Clin. Nutr. 2008;87:778–784.
    1. Takahashi M, et al. Effects of timing of acute catechin-rich green tea ingestion on postprandial glucose metabolism in healthy men. J. Nutritional Biochem. 2019;73:108221.
    1. Van Dam RM, Feskens EJ. Coffee consumption and risk of type 2 diabetes mellitus. Lancet. 2002;360:1477–1478.
    1. Van Dam RM, Hu FB. Coffee consumption and risk of type 2 diabetes: a systematic review. JAMA. 2005;294:97–104.
    1. Sartorelli DS, et al. Differential effects of coffee on the risk of type 2 diabetes according to meal consumption in a French cohort of women: the E3N/EPIC cohort study. Am. J. Clin. Nutr. 2010;91:1002–1012.
    1. Moisey LL, Robinson LE, Graham TE. Consumption of caffeinated coffee and a high carbohydrate meal affects postprandial metabolism of a subsequent oral glucose tolerance test in young, healthy males. Br. J. Nutr. 2010;103:833–841.
    1. Bo S, et al. Is the timing of caloric intake associated with variation in diet-induced thermogenesis and in the metabolic pattern? A randomized cross-over study. Int. J. Obes. 2015;39:1689.
    1. Takahashi M, et al. Effects of meal timing on postprandial glucose metabolism and blood metabolites in healthy adults. Nutrients. 2018;10:1763.

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