European Consensus Guidelines on the Management of Respiratory Distress Syndrome: 2022 Update

David G Sweet, Virgilio P Carnielli, Gorm Greisen, Mikko Hallman, Katrin Klebermass-Schrehof, Eren Ozek, Arjan Te Pas, Richard Plavka, Charles C Roehr, Ola D Saugstad, Umberto Simeoni, Christian P Speer, Maximo Vento, Gerry H A Visser, Henry L Halliday, David G Sweet, Virgilio P Carnielli, Gorm Greisen, Mikko Hallman, Katrin Klebermass-Schrehof, Eren Ozek, Arjan Te Pas, Richard Plavka, Charles C Roehr, Ola D Saugstad, Umberto Simeoni, Christian P Speer, Maximo Vento, Gerry H A Visser, Henry L Halliday

Abstract

Respiratory distress syndrome (RDS) care pathways evolve slowly as new evidence emerges. We report the sixth version of "European Guidelines for the Management of RDS" by a panel of experienced European neonatologists and an expert perinatal obstetrician based on available literature up to end of 2022. Optimising outcome for babies with RDS includes prediction of risk of preterm delivery, appropriate maternal transfer to a perinatal centre, and appropriate and timely use of antenatal steroids. Evidence-based lung-protective management includes initiation of non-invasive respiratory support from birth, judicious use of oxygen, early surfactant administration, caffeine therapy, and avoidance of intubation and mechanical ventilation where possible. Methods of ongoing non-invasive respiratory support have been further refined and may help reduce chronic lung disease. As technology for delivering mechanical ventilation improves, the risk of causing lung injury should decrease, although minimising time spent on mechanical ventilation by targeted use of postnatal corticosteroids remains essential. The general care of infants with RDS is also reviewed, including emphasis on appropriate cardiovascular support and judicious use of antibiotics as being important determinants of best outcome. We would like to dedicate this guideline to the memory of Professor Henry Halliday who died on November 12, 2022.These updated guidelines contain evidence from recent Cochrane reviews and medical literature since 2019. Strength of evidence supporting recommendations has been evaluated using the GRADE system. There are changes to some of the previous recommendations as well as some changes to the strength of evidence supporting recommendations that have not changed. This guideline has been endorsed by the European Society for Paediatric Research (ESPR) and the Union of European Neonatal and Perinatal Societies (UENPS).

Keywords: Antenatal corticosteroids; Continuous positive airway pressure; Evidence-based practice; Mechanical ventilation; Non-invasive respiratory support; Nutrition; Oxygen supplementation; Patent ductus arteriosus; Preterm infant; Respiratory distress syndrome; Surfactant therapy; Thermoregulation.

Conflict of interest statement

Henry L. Halliday, Christian P. Speer, and Charles C. Roehr in the past have been consultants to Chiesi Farmaceutici, Parma, the manufacturer of a leading animal-derived surfactant preparation used to treat RDS and a caffeine product for treatment of apnoea of prematurity. Virgilio Carnielli is a member of the Chiesi Farmaceutici Advisory Board. Henry Halliday and Christian Speer are joint chief editors of Neonatology.

© 2023 S. Karger AG, Basel.

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