Implementing of aMMP-8 point-of-care test with a modified new disease classification in Finnish adolescent cohorts

Anna M Heikkinen, Teija Raivisto, Ismo Räisänen, Taina Tervahartiala, Nagihan Bostanci, Timo Sorsa, Anna M Heikkinen, Teija Raivisto, Ismo Räisänen, Taina Tervahartiala, Nagihan Bostanci, Timo Sorsa

Abstract

Objectives: Periodontitis is a multifactorial biofilm-induced inflammatory disease; however, clinical and radiographic information reflects events that have already occurred. aMMP-8 lateral-flow chairside or point-of-care-test (POC-test) results have also come to complement the overall status of the patient's current situation. The current study aimed to clarify the usefulness of aMMP-8 chairside-test (aMMP-8 POCT) results to alert the initial or early periodontitis in adolescents, a potential periodontitis risk group with cut off 20 ng/ml in Stage I periodontitis, according to the current periodontitis classification system.

Material and methods: A total of 117 adolescents were aMMP-8 POC tested for aMMP-8 levels and examined for the full mouth and were interviewed for questions concerning health behavior.

Results: Of all 117 participants, N = 38 (32.5%) was aMMP-8 POCT positive, and N = 34 (29.1%) had at least one 4 mm periodontal deepened pocket; however, only N = 16 (13.7%) had both characteristics. The subclinical stage (N = 47) could not be classified either as gingivitis or Stage I. Of the participants, who did not have any deepened periodontal pockets, 18 tested negative.

Conclusions: Stage I is preceded by antecedent stages that should be tackled by oral healthcare prevention and personalized treatment modalities by professionals. Elevated (>20 ng/ml), positive aMMP-8 POCT results can be regarded as initial alarmer such as emerging risk. This should be utilized in the preventive personalized interventions by oral health professionals.

Keywords: adolescent; gingivitis; matrix metalloproteinase 8; periodontitis.

Conflict of interest statement

Timo Sorsa is an inventor of US patent numbers of 5652223, 5736341, 5866432, 6143476, 20170023571A1 (granted 6.6.2019), WO 2018/060553 A1 (granted 31.5.2018), 10 488 415 B2, and a Japanese patent 2016‐554676. The remaining authors declare no conflict of interest.

© 2022 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd.

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