Taste disturbance in patients with advanced cancer: a scoping review of clinical features and complications

Marie Hannon, Annelie Shaw, Michael Connolly, Andrew Davies, Marie Hannon, Annelie Shaw, Michael Connolly, Andrew Davies

Abstract

Purpose: The purpose of this scoping review is to appraise the published literature on taste disturbance in patients with advanced cancer, with the specific objectives being to determine its prevalence, clinical features and complications.

Methods: This scoping review was conducted using the recommended methodological framework. A detailed search of databases (Medline, Embase, CINAHL and PsycInfo) was conducted to identify eligible studies: eligible studies needed to include patients with advanced cancer and needed to include details of clinical features and/or complications of taste disturbance. Standard bibliographic/systematic review software was used to store the records and manage the review process, respectively.

Results: Twenty-five studies were identified from the database searches. The studies identified included eight physical and/or psychological symptom studies, six symptom cluster studies, five oral symptom studies and six taste and/or smell specific studies. Detailed data is presented on the clinical features and complications of taste disturbance and on the symptom clusters involving taste disturbance in this cohort of patients.

Conclusion: This scoping review identified a relatively small number of relevant studies involving a relatively small number of participants. Nevertheless, it confirms that taste disturbance is a common problem in patients with advanced cancer and is associated with significant morbidity because of the primary condition and the associated complications.

Keywords: Neoplasms; Palliative care; Taste; Taste disorders.

Conflict of interest statement

The authors declare no competing interests.

© 2023. The Author(s).

Figures

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Fig. 1
Flow chart of article inclusion

References

    1. Breslin PA, Spector AC. Mammalian taste perception. Curr Biol. 2008;18:R148–R155. doi: 10.1016/j.cub.2007.12.017.
    1. Boltong A, Keast R, Aranda SK. Talking about taste: how do oncology clinicians discuss and document taste problems? Cancer Forum. 2011;35:81–87.
    1. Galaniha LT, Nolden AA. Taste loss in cancer patients: clinicians’ perceptions of educational materials and diagnostic tools. Support Care Cancer. 2023;31:349. doi: 10.1007/s00520-023-07794-4.
    1. Boltong A, Keast RS, Aranda SK. A matter of taste: making the distinction between taste and flavor is essential for improving management of dysgeusia. Support Care Cancer. 2011;19:441–442. doi: 10.1007/s00520-011-1085-0.
    1. Boltong A, Keast R. The influence of chemotherapy on taste perception and food hedonics: a systematic review. Cancer Treat Rev. 2012;38:152–163. doi: 10.1016/j.ctrv.2011.04.008.
    1. Mela DJ. Eating for pleasure or just wanting to eat? Reconsidering sensory hedonic responses as a driver of obesity. Appetite. 2006;47:10–17. doi: 10.1016/j.appet.2006.02.006.
    1. Epstein JB, Barasch A. Taste disorders in cancer patients: pathogenesis, and approach to assessment and management. Oral Oncol. 2010;46:77–81. doi: 10.1016/j.oraloncology.2009.11.008.
    1. Hovan AJ, Williams PM, Stevenson-Moore P, Wahlin YB, Ohrn KE, Elting LS, Spijkervet FK, Brennan MT. A systematic review of dysgeusia induced by cancer therapies. Support Care Cancer. 2010;18:1081–1087. doi: 10.1007/s00520-010-09021.
    1. Henkin RI, Levy LM, Fordyce A. Taste and smell function in chronic disease: a review of clinical and biochemical evaluations of taste and smell dysfunction in over 5000 patients at The Taste and Smell Clinic in Washington, DC. Am J Otolaryngol. 2013;34:477–489. doi: 10.1016/j.amjoto.2013.04.006.
    1. Liu G, Zong G, Doty RL, Sun Q. Prevalence and risk factors of taste and smell impairment in a nationwide representative sample of the US population: a cross-sectional study. BMJ Open. 2016;6:e013246. doi: 10.1136/bmjopen-2016-013246.
    1. Barasch A, Epstein JB. Evaluation of taste disorders. 2022.
    1. Spotten LE, Corish CA, Lorton CM, Ui Dhuibhir PM, O'Donoghue NC, O’Connor B, Walsh TD. Subjective and objective taste and smell changes in cancer. Ann Oncol. 2017;28:969–984. doi: 10.1093/annonc/mdx018.
    1. Ui Dhuibhir P, Barrett M, O’Donoghue N, Gillham C, El Beltagi N, Walsh D. Self-reported and objective taste and smell evaluation in treatment-naive solid tumour patients. Support Care Cancer. 2020;28:2389–2396. doi: 10.1007/s00520-019-05017-3.
    1. Buttiron Webber T, Briata IM, DeCensi A, Cevasco I, Paleari L (2023) Taste and smell disorders in cancer treatment: results from an integrative rapid systematic review. Int J Mol Sci 24. 10.3390/ijms24032538
    1. Gunn L, Gilbert J, Nenclares P, Soliman H, Newbold K, Bhide S, Wong KH, Harrington K, Nutting C. Taste dysfunction following radiotherapy to the head and neck: a systematic review. Radiother Oncol. 2021;157:130–140. doi: 10.1016/j.radonc.2021.01.021.
    1. Epstein JB, de Andrade ESSM, Epstein GL, Leal JHS, Barasch A, Smutzer G (2019) Taste disorders following cancer treatment: report of a case series. Support Care Cancer 27: 4587-4595.
    1. Ripamonti C, Fulfaro F. Taste disturbance. In: Davies AN, Epstein JB, editors. Oral complications of cancer and its management. Oxford: Oxford University Press; 2010. pp. 225–232.
    1. Spencer AS, da Silva DD, Capelas ML, Pimentel F, Santos T, Neves PM, Makitie A, Ravasco P. Managing severe dysgeusia and dysosmia in lung cancer patients: a systematic scoping review. Front Oncol. 2021;11:774081. doi: 10.3389/fonc.2021.774081.
    1. Pellegrini M, Merlo FD, Agnello E, Monge T, Devecchi A, Casalone V, Montemurro F, Ghigo E, Sapino A, Bo S (2023) Dysgeusia in patients with breast cancer treated with chemotherapy-a narrative review. Nutrients 15. 10.3390/nu15010226
    1. Togni T, L, Mascitti M, Vignigni A, Alia S, Sartini D, Barlattani A, Emanuelli M, Santarelli A (2021) Treatment-related dysgeusia in oral and oropharyngeal cancer: a comprehensive review. Nutrients 13. 10.3390/nu13103325
    1. Deshpande TS, Blanchard P, Wang L, Foote RL, Zhang X, Frank SJ. Radiation-related alterations of taste function in patients with head and neck cancer: a systematic review. Curr Treat Options Oncol. 2018;19:72. doi: 10.1007/s11864-018-0580-7.
    1. Twycross RG, Lack SA. Control of alimentary symptoms in far advanced cancer. Edinburgh: Churchill Livingstone; 1986.
    1. Santini D, Armento G, Giusti R, Ferrara M, Moro C, Fulfaro F, Bossi P, Arena F, Ripamonti CI. Management of orphan symptoms: ESMO Clinical Practice Guidelines for diagnosis and treatment. ESMO Open. 2020;5:e000933. doi: 10.1136/esmoopen-2020-000933.
    1. Arksey H, O’Malley L. Scoping studies: towards a methodological framework. Int. J. Soc. Res. Methodol. 2005;8:19–32. doi: 10.1080/1364557032000119616.
    1. Peters MDJ, Marnie C, Tricco AC, Pollock D, Munn Z, Alexander L, McInerney P, Godfrey CM, Khalil H. Updated methodological guidance for the conduct of scoping reviews. JBI Evid Implement. 2021;19:3–10. doi: 10.11124/JBIES-20-00167.
    1. McGowan J, Straus S, Moher D, Langlois EV, O'Brien KK, Horsley T, Aldcroft A, Zarin W, Garitty CM, Hempel S, Lillie E, Tuncalp Ӧ, Tricco AC. Reporting scoping reviews-PRISMA ScR extension. J Clin Epidemiol. 2020;123:177–179. doi: 10.1016/j.jclinepi.2020.03.016.
    1. National Cancer Institute Dictionary of Cancer Terms (2022) .
    1. Aktas A, Walsh D, Hu B. Cancer symptom clusters: an exploratory analysis of eight statistical techniques. J Pain Symptom Manage. 2014;48:1254–1266. doi: 10.1016/j.jpainsymman.2014.02.006.
    1. Bovio G, Montagna G, Bariani C, Baiardi P. Upper gastrointestinal symptoms in patients with advanced cancer: relationship to nutritional and performance status. Support Care Cancer. 2009;17:1317–1324. doi: 10.1007/s00520-009-0590-x.
    1. Brisbois TD, de Kock IH, Watanabe SM, Baracos VE, Wismer WV. Characterization of chemosensory alterations in advanced cancer reveals specific chemosensory phenotypes impacting dietary intake and quality of life. J Pain Symptom Manage. 2011;41:673–683. doi: 10.1016/j.jpainsymman.2010.06.022.
    1. Mahmoud FA, Aktas A, Walsh D, Hullihen B. A pilot study of taste changes among hospice inpatients with advanced cancer. Am J Hosp Palliat Care. 2011;28:487–492. doi: 10.1177/1049909111402187.
    1. Ozalp GS, Uysal N, Oguz G, Kocak N, Karaca S, Kadiogullari N. Identification of symptom clusters in cancer patients at palliative care clinic. Asia Pac J Oncol Nurs. 2017;4:259–264. doi: 10.4103/apjon.apjon_17_17.
    1. Sweeney MP, Bagg J, Baxter WP, Aitchison TC. Oral disease in terminally ill cancer patients with xerostomia. Oral Oncol. 1998;34:123–126. doi: 10.1016/s1368-8375(97)00076-6.
    1. Tebidze N, Chikhladze NJ, E. Margvelashvili, V. Jincharadze, M. , Kordzaia D (2019) Perception of oral problems in patients with advanced cancer. Georgian Med News:50–56
    1. Alsirafy SA, Abd El-Aal HH, Farag DE, Radwan RH, El-Sherief WA, Fawzy R. High symptom burden among patients with newly diagnosed incurable cancer in a developing country. J Pain Symptom Manage. 2016;51:e1–e5. doi: 10.1016/j.jpainsymman.2016.02.003.
    1. Alt-Epping B, Nejad RK, Jung K, Gross U, Nauck F (2012) Symptoms of the oral cavity and their association with local microbiological and clinical findings--a prospective survey in palliative care. Support Care Cancer 20:531–537. 10.1007/s00520-011-1114-z
    1. Chaiviboontham SVH, McCorkle S, R. Symptom clusters in Thais with advanced cancer. Pac Rim Int J Nurs Res. 2011;14:265–277.
    1. Davies A, Buchanan A, Todd J, Gregory A, Batsari KM. Oral symptoms in patients with advanced cancer: an observational study using a novel oral symptom assessment scale. Support Care Cancer. 2021;29:4357–4364. doi: 10.1007/s00520-020-05903-1.
    1. Davies AN. An investigation into the relationship between salivary gland hypofunction and oral health problems in patients with advanced cancer. Kings College London; 2000.
    1. Davies AN, Kaur K. Taste problems in patients with advanced cancer. Palliative Medicine. 1998;12:482–483.
    1. Hutton JL, Baracos VE, Wismer WV. Chemosensory dysfunction is a primary factor in the evolution of declining nutritional status and quality of life in patients with advanced cancer. J Pain Symptom Manage. 2007;33:156–165. doi: 10.1016/j.jpainsymman.2006.07.017.
    1. Kirkova J, Walsh D, Rybicki L, Davis MP, Aktas A, Tao J, Homsi J. Symptom severity and distress in advanced cancer. Palliat Med. 2010;24:330–339. doi: 10.1177/0269216309356380.
    1. Kirkova J, Aktas A, Walsh D, Rybicki L, Davis MP. Consistency of symptom clusters in advanced cancer. Am J Hosp Palliat Care. 2010;27:342–346. doi: 10.1177/1049909110369869.
    1. McGettigan N, Dhuibhir PU, Barrett M, Sui J, Balding L, Higgins S, O’Leary N, Kennedy A, Walsh D. Subjective and objective assessment of taste and smell sensation in advanced cancer. Am J Hosp Palliat Care. 2019;36:688–696. doi: 10.1177/1049909119832836.
    1. O’Donoghue A, Barrett M, Dhuibhir PU, Kennedy A, O’Leary N, Walsh D. Taste and smell abnormalities in advanced cancer: negative impact on subjective food intake. Nutr Clin Pract. 2023;1:1–10. doi: 10.1002/ncp.10943.
    1. Spichiger E, Muller-Frohlich C, Denhaerynck K, Stoll H, Hantikainen V, Dodd M. Symptom prevalence and changes of symptoms over ten days in hospitalized patients with advanced cancer: a descriptive study. Eur J Oncol Nurs. 2011;15:95–102. doi: 10.1016/j.ejon.2010.06.005.
    1. Tranmer JE, Heyland D, Dudgeon D, Groll D, Squires-Graham M, Coulson K. Measuring the symptom experience of seriously ill cancer and noncancer hospitalized patients near the end of life with the memorial symptom assessment scale. J Pain Symptom Manage. 2003;25:420–429. doi: 10.1016/s0885-3924(03)00074-5.
    1. Tsai JS, Wu CH, Chiu TY, Chen CY. Significance of symptom clustering in palliative care of advanced cancer patients. J Pain Symptom Manage. 2010;39:655–662. doi: 10.1016/j.jpainsymman.2009.09.005.
    1. Van Lancker A, Beeckman D, Van Den Noortgate N, Verhaeghe S, Van Hecke A. Frequency and intensity of symptoms and treatment interventions in hospitalized older palliative cancer patients: a multicentre cross-sectional study. J Adv Nurs. 2017;73:1455–1466. doi: 10.1111/jan.13230.
    1. Walsh D, Rybicki L. Symptom clustering in advanced cancer. Support Care Cancer. 2006;14:831–836. doi: 10.1007/s00520-005-0899-z.
    1. Webber K, Davies AN, Leach C, Waghorn M. Symptom prevalence and severity in palliative cancer medicine. BMJ Support Palliat Care. 2021;0:1–3. doi: 10.1136/bmjspcare-2020-002357.
    1. Webber K, Davies AN. Validity of the memorial symptom assessment scale-short form psychological subscales in advanced cancer patients. J Pain Symptom Manage. 2011;42:761–767. doi: 10.1016/j.jpainsymman.2011.02.007.
    1. Heald A, Pieper CF, Schiffman SS. Taste and smell complaints in HIV-infected patients. AIDS. 1998;12:1667–1674. doi: 10.1097/00002030-199813000-00015.
    1. Chang VT, Hwang SS, Feuerman M, Kasimis BS, Thaler HT. The memorial symptom assessment scale short form (MSAS-SF) Cancer. 2000;89:1162–1171. doi: 10.1002/1097-0142.
    1. Van Lancker A, Beeckman D, Verhaeghe S, Van Den Noortgate N, Grypdonck M, Van Hecke A. An instrument to collect data on frequency and intensity of symptoms in older palliative cancer patients: a development and validation study. Eur J Oncol Nurs. 2016;21:38–47. doi: 10.1016/j.ejon.2015.11.003.
    1. Henkin RI, Schechter PJ, Hoye R, Mattern CFT. Idiopathic hypogeusia with dysgeusia, hyposmia, and dysosmia. A new syndrome. JAMA. 1971;217:434–440.
    1. Portenoy RK, Thaler HT, Kornblith AB, McCarthy Lepore J, Friedlander-Klar H, Kiyasu E, Sobel K, Coyle N, Kemeny N, Norton L, Scher H. The Memorial Symptom Assessment Scale: an instrument for the evaluation of symptom prevalence, characteristics, and distress. Eur J Cancer. 1994;30:1226–1236. doi: 10.1016/0959-8049(94)90182-1.
    1. Epstein JB, Smutzer G, Doty RL. Understanding the impact of taste changes in oncology care. Support Care Cancer. 2016;24:1917–1931. doi: 10.1007/s00520-016-3083-8.
    1. Enriquez-Fernandez BE, Martinez-Michel L, Thorlakson J, Wismer WV. Patient-reported taste change assessment questionnaires used in the oncology setting: a narrative review. Eur J Oncol Nurs. 2020;47:101775. doi: 10.1016/j.ejon.2020.101775.
    1. Walsh D, Donnelly S, Rybicki L. The symptoms of advanced cancer: relationship to age, gender, and performance status in 1,000 patients. Support Care Cancer. 2000;8:175–179. doi: 10.1007/s005200050281.
    1. Davies AN, Broadley K, Beighton D. Xerostomia in patients with advanced cancer. J Pain Symptom Manage. 2001;22:820–825. doi: 10.1016/s0885-3924(01)00318-9.
    1. Dong ST, Butow PN, Costa DS, Lovell MR, Agar M. Symptom clusters in patients with advanced cancer: a systematic review of observational studies. J Pain Symptom Manage. 2014;48:411–450. doi: 10.1016/j.jpainsymman.2013.10.027.
    1. DeWys WD, Walters K. Abnormalities of taste sensation in cancer patients. Cancer. 1975;36:1888–1896. doi: 10.1002/10970142.
    1. Rydholm M, Strang P. Physical and psychosocial impact of xerostomia in palliative cancer care: a qualitative interview study. Int J Palliat Nurs. 2002;8:318–323. doi: 10.12968/ijpn.2002.8.7.10671.
    1. Hopkinson JB. How people with advanced cancer manage changing eating habits. J Adv Nurs. 2007;59:454–462. doi: 10.1111/j.1365-2648.2007.04283.x.
    1. Zhou T, Yang K, Thapa S, Liu H, Wang B, Yu S. Differences in symptom burden among cancer patients with different stages of cachexia. J Pain Symptom Manage. 2017;53:919–926. doi: 10.1016/j.jpainsymman.2016.12.325.
    1. Jones JA, Chavarri-Guerra Y, Correa LBC, Dean DR, Epstein JB, Fregnani ER, Lee J, Matsuda Y, Mercadante V, Monsen RE, Rajimakers NJH, Saunders D, Soto-Perez-de-Celis E, Sousa MS, Tonkaboni A, Vissink A, Yeoh KS, Davies AN. MASCC/ISOO expert opinion on the management of oral problems in patients with advanced cancer. Support Care Cancer. 2022;30:8761–8773. doi: 10.1007/s00520-022-07211-2.
    1. Alderman B, Allan L, Amano K, Bouleuc C, Davis M, Lister-Flynn S, Mukhopadhyay S, Davies A. Multinational Association of Supportive Care in Cancer (MASCC) expert opinion/guidance on the use of clinically assisted nutrition in patients with advanced cancer. Support Care Cancer. 2022;30:2983–2992. doi: 10.1007/s00520-021-06613-y.

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